The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. (Q38732625)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

11 February 2020

main subject

Drosophila

0 references

1 reference

1 reference

GOA release 2020-03-11

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Jonathan R Brent

1 reference

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11 February 2020

Andrew Tomlinson

series ordinal

1 reference

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11 February 2020

language of work or name

English

0 references

publication date

1 September 2011

1 reference

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Journal of Clinical Investigation

11 February 2020

published in

1 reference

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11 February 2020

volume

121

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11 February 2020

issue

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11 February 2020

page(s)

4118-4126

1 reference

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A yeast model of FUS/TLS-dependent cytotoxicity

11 February 2020

cites work

1 reference

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Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

6 September 2017

1 reference

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Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

6 September 2017

1 reference

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TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

6 September 2017

1 reference

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TDP-43-mediated neuron loss in vivo requires RNA-binding activity

6 September 2017

1 reference

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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

6 September 2017

1 reference

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Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

6 September 2017

1 reference

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Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

6 September 2017

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

6 September 2017

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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

6 September 2017

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FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis

6 September 2017

1 reference

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TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

6 September 2017

1 reference

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RNA processing pathways in amyotrophic lateral sclerosis

6 September 2017

1 reference

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De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis

6 September 2017

1 reference

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Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).

6 September 2017

1 reference

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A Drosophila model for TDP-43 proteinopathy

6 September 2017

1 reference

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

6 September 2017

1 reference

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

The molecular links between TDP-43 dysfunction and neurodegeneration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

High-resolution video tracking of locomotion in adult Drosophila melanogaster

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Rethinking ALS: the FUS about TDP-43.

6 September 2017

1 reference

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

6 September 2017

1 reference

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Recombinases and their use in gene activation, gene inactivation, and transgenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

The GAL4 system : a versatile system for the expression of genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Tools for neuroanatomy and neurogenetics in Drosophila

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Amyotrophic lateral sclerosis.

6 September 2017

1 reference

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An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

A test of insulator interactions in Drosophila.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

The FLAG peptide, a versatile fusion tag for the purification of recombinant proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

DNA cloning using in vitro site-specific recombination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

A modular misexpression screen in Drosophila detecting tissue-specific phenotypes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Drosophila larval NMJ immunohistochemistry

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Drosophila larval NMJ dissection

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195475

31 August 2018

Identifiers

DOI

10.1172/JCI57883

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

21881207

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21881207%20AND%20SRC:MED&resulttype=core&format=json