Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody. (Q38718049)

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7 March 2020

title

Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody (English)

1 reference

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7 March 2020

0 references

1 reference

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7 March 2020

Sylvie Jorieux

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7 March 2020

Nathalie Souyris

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7 March 2020

Ouafa Zaki

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7 March 2020

Alexandra Jacquet

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7 March 2020

Nathalie Fournier

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7 March 2020

Fabien Crozet

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7 March 2020

Christophe de Romeuf

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7 March 2020

Khalil Bouayadi

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7 March 2020

Rémi Urbain

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7 March 2020

Christian K Behrens

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7 March 2020

Philippe Mondon

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7 March 2020

Alexandre Fontayne

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7 March 2020

publication date

15 January 2014

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7 March 2020

published in

Monoclonal Antibodies

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7 March 2020

volume

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7 March 2020

issue

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7 March 2020

page(s)

422-436

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A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults

7 March 2020

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6 September 2017

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Dependence of antibody-mediated presentation of antigen on FcRn

6 September 2017

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When binding is enough: nonactivating antibody formats.

6 September 2017

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A novel random mutagenesis approach using human mutagenic DNA polymerases to generate enzyme variant libraries.

6 September 2017

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The immunoglobulin constant region contributes to affinity and specificity

6 September 2017

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FcRn: the neonatal Fc receptor comes of age.

6 September 2017

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6 September 2017

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Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

6 September 2017

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6 September 2017

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Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

6 September 2017

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Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

6 September 2017

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

6 September 2017

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Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

6 September 2017

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Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

6 September 2017

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Increasing the serum persistence of an IgG fragment by random mutagenesis.

6 September 2017

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The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn

6 September 2017

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Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

6 September 2017

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Preclinical study of Ublituximab, a Glycoengineered anti-human CD20 antibody, in murine models of primary cerebral and intraocular B-cell lymphomas

6 September 2017

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Enhanced antibody half-life improves in vivo activity

6 September 2017

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Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.

14 September 2017

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Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor

14 September 2017

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Selection of a human anti-RhD monoclonal antibody for therapeutic use: impact of IgG glycosylation on activating and inhibitory Fc gamma R functions

14 September 2017

1 reference

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Engineered human IgG antibodies with longer serum half-lives in primates

14 September 2017

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Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies

14 September 2017

1 reference

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Marketing approval of mogamulizumab: a triumph for glyco-engineering

23 June 2018

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High-Affinity Binding of the Neonatal Fc Receptor to Its IgG Ligand Requires Receptor Immobilization

23 June 2018

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Cassette baculovirus vectors for the production of chimeric, humanized, or human antibodies in insect cells.

23 June 2018

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Qualification of a homogeneous cell-based neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics

23 June 2018

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Reduced elimination of IgG antibodies by engineering the variable region

31 August 2018

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Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

31 August 2018

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Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.

31 August 2018

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Chronic lymphocytic leukaemia cells are efficiently killed by an anti-CD20 monoclonal antibody selected for improved engagement of FcgammaRIIIA/CD16.

31 August 2018

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A human anti-D monoclonal antibody selected for enhanced FcgammaRIII engagement clears RhD+ autologous red cells in human volunteers as efficiently as polyclonal anti-D antibodies

31 August 2018

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Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

31 August 2018

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Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

31 August 2018

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An engineered human IgG1 antibody with longer serum half-life

31 August 2018

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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels

31 August 2018

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Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship.

31 August 2018

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Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

31 August 2018

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Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary struc

31 August 2018

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High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

31 August 2018

1 reference

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Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

31 August 2018

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Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies

1 October 2018

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Crossref

https://api.crossref.org/works/10.4161%2FMABS.27854

Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor

21 January 2018

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12 December 2020

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

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12 December 2020

FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis

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12 December 2020

Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors

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12 December 2020

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

1 reference

12 December 2020

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

1 reference

12 December 2020

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

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12 December 2020

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene

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12 December 2020

Identifiers

DOI

10.4161/MABS.27854

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24492301%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24492301%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

24492301

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24492301%20AND%20SRC:MED&resulttype=core&format=json