Modulators of microglia: a patent review (Q38685760)

5 September 2017

title

Modulators of microglia: a patent review (English)

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5 September 2017

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Simonetta Papa

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Pietro Veglianese

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Ilaria Caron

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5 September 2017

Filippo Rossi

series ordinal

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5 September 2017

language of work or name

English

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publication date

4 January 2016

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Expert Opinion on Therapeutic Patents

5 September 2017

published in

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5 September 2017

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5 September 2017

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5 September 2017

page(s)

427-437

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Ontogeny and functions of central nervous system macrophages.

5 September 2017

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Microglial interactions with synapses are modulated by visual experience

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Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

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Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.

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Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis

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Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

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The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS

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Synaptic pruning by microglia is necessary for normal brain development

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Roles of microglia in brain development, tissue maintenance and repair.

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Microglia development and function

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Microglial and macrophage polarization—new prospects for brain repair

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Macrophage plasticity and polarization in liver homeostasis and pathology

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Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

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Alternatively activated microglia and macrophages in the central nervous system.

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Repertoire of microglial and macrophage responses after spinal cord injury

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Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer 'if' but 'how'.

21 January 2018

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

21 January 2018

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The chemokine system in diverse forms of macrophage activation and polarization

21 January 2018

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Other functions, other genes: alternative activation of antigen-presenting cells

21 January 2018

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Alternative versus classical activation of macrophages.

21 January 2018

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The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus.

21 January 2018

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Does neuroinflammation fan the flame in neurodegenerative diseases?

21 January 2018

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The role of the microglia in acute CNS injury

21 January 2018

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Function of microglia and macrophages in secondary damage after spinal cord injury

21 January 2018

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Microglia centered pathogenesis in ALS: insights in cell interconnectivity

21 January 2018

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Microglial dysfunction in brain aging and Alzheimer's disease

21 January 2018

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Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

21 January 2018

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Epilepsy and brain inflammation

21 January 2018

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Macrophage subsets and microglia in multiple sclerosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

21 January 2018

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Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Minocycline selectively inhibits M1 polarization of microglia

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Targeting PPAR isoforms following CNS injury

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Control of macrophage activation and function by PPARs

21 January 2018

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The PPAR gamma agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury.

21 January 2018

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Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis

21 January 2018

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Selective oestrogen receptor modulators decrease the inflammatory response of glial cells

21 January 2018

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Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis

21 January 2018

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Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage

21 January 2018

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Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

21 January 2018

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Inhibition of LPS-induced retinal microglia activation by naloxone does not prevent photoreceptor death

21 January 2018

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Therapeutic siRNA silencing in inflammatory monocytes in mice

21 January 2018

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Tumor Necrosis Factor-α Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury

21 January 2018

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Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor.

21 January 2018

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CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Genetic targeting of microglia

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors

21 January 2018

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Onset and progression in inherited ALS determined by motor neurons and microglia

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Temporal changes in monocyte and macrophage subsets and microglial macrophages following spinal cord injury in the Lys-Egfp-ki mouse model

21 January 2018

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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

21 January 2018

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Microglia, seen from the CX3CR1 angle

21 January 2018

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Visualization of microglia in living tissues using Iba1-EGFP transgenic mice

21 January 2018

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Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice

21 January 2018

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Lysosomal storage disease: gene therapy on both sides of the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Neuroinflammation and cell therapy for Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma

21 January 2018

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Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis

21 January 2018

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Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives.

21 January 2018

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The MSC: An Injury Drugstore

21 January 2018

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Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy

21 January 2018

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Multipotent mesenchymal stromal cells and the innate immune system

21 January 2018

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Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury

21 January 2018

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Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury

21 January 2018

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Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury.

21 January 2018

1 reference

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Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Anti-inflammatory treatments during the chronic phase of spinal cord injury improve locomotor function in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Targeting microglial activation in stroke therapy: pharmacological tools and gender effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Minocycline: far beyond an antibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat.

21 January 2018

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Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice

21 January 2018

1 reference

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Differential expression of chemokines and chemokine receptors during microglial activation and inhibition

21 January 2018

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Granulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Rosiglitazone, a peroxisome proliferator-activated receptor-gamma ligand, reduces infarction volume and neurological deficits in an embolic model of stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Targeting the peroxisome proliferator-activated receptors (PPARs) in spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro

21 January 2018

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The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma

21 January 2018

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Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Enhanced disruption of the blood brain barrier by intracarotid mannitol injection during transient cerebral hypoperfusion in rabbits

21 January 2018

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The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier: from concept to clinical evaluation

21 January 2018

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Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications

21 January 2018

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Ultrasound for drug and gene delivery to the brain

21 January 2018

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Recent advances in blood-brain barrier transport

21 January 2018

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Targeted drug delivery to macrophages

21 January 2018

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Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury

21 January 2018

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Nanovector-mediated drug delivery for spinal cord injury treatment.

21 January 2018

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Current options for drug delivery to the spinal cord

21 January 2018

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Selective targeting of microglia by quantum dots.

21 January 2018

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Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Macrophage activation and its role in repair and pathology after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Inflammation in neurodegenerative diseases--an update

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Nanomedicine for treating spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of CX3CL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2016.1135901

10.1517/13543776.2016.1135901

21 January 2018

Identifiers

DOI

1 reference

5 September 2017

1 reference