CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells (Q38672092)

8 January 2018

title

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells (English)

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8 January 2018

author name string

Jing Zhang

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8 January 2018

Xueliang Gao

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8 January 2018

Fabienne Schmit

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8 January 2018

Guillaume Adelmant

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8 January 2018

Michael J Eck

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8 January 2018

Jarrod A Marto

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8 January 2018

Jean J Zhao

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8 January 2018

Thomas M Roberts

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8 January 2018

publication date

1 July 2017

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8 January 2018

published in

Cell Reports

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8 January 2018

volume

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8 January 2018

issue

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8 January 2018

page(s)

549-557

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8 January 2018

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

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23 June 2018

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Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent

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Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers

23 June 2018

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Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival

23 June 2018

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Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

23 June 2018

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A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice

23 June 2018

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Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

23 June 2018

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Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation

23 June 2018

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Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

23 June 2018

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p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

23 June 2018

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23 June 2018

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23 June 2018

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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

23 June 2018

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PTEN-deficient cancers depend on PIK3CB.

23 June 2018

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Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

23 June 2018

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A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

23 June 2018

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The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration

23 June 2018

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The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

23 June 2018

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The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

23 June 2018

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23 June 2018

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23 June 2018

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Phosphoinositide 3-kinase-dependent activation of Rac.

23 June 2018

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Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases

23 June 2018

1 reference

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T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein

23 June 2018

1 reference

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PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

23 June 2018

1 reference

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

23 June 2018

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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

23 June 2018

1 reference

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10.1016/J.CELREP.2017.06.054

23 June 2018

Identifiers

DOI

1 reference

8 January 2018

PMC publication ID

5704918

1 reference

8 January 2018

PubMed publication ID

28723560

1 reference

8 January 2018