Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells (Q38649916)

5 September 2017

Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells (English)

1 reference

5 September 2017

0 references

1 reference

ChEBI release 2020-05-28

ChEBI ID

132893

hepatocellular carcinoma

1 reference

1 reference

Ning Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21418191

27 November 2024

Weidong Pan

1 reference

5 September 2017

Meifen Zhu

1 reference

5 September 2017

Maosheng Zhang

1 reference

5 September 2017

Xiaojian Hao

1 reference

5 September 2017

Guangyi Liang

1 reference

5 September 2017

Yibin Feng

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5 September 2017

language of work or name

English

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publication date

1 September 2011

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5 September 2017

September 2011

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21418191

full work available at URL

27 November 2024

https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2011.01349.x

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Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21418191

https://europepmc.org/articles/PMC3188903

27 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21418191

https://europepmc.org/articles/PMC3188903?pdf=render

27 November 2024

file format

Portable Document Format

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open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21418191

https://doi.org/10.1111/j.1476-5381.2011.01349.x

27 November 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21418191

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.2011.01349.x

27 November 2024

1 reference

https://api.crossref.org/works/10.1111/J.1476-5381.2011.01349.X

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2011.01349.x

27 November 2024

1 reference

https://api.crossref.org/works/10.1111/J.1476-5381.2011.01349.X

https://onlinelibrary.wiley.com/doi/full-xml/10.1111/j.1476-5381.2011.01349.x

27 November 2024

1 reference

https://api.crossref.org/works/10.1111/J.1476-5381.2011.01349.X

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2011.01349.x

27 November 2024

1 reference

https://api.crossref.org/works/10.1111/J.1476-5381.2011.01349.X

British Journal of Pharmacology

27 November 2024

published in

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5 September 2017

164

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5 September 2017

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5 September 2017

731-742

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Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

5 September 2017

1 reference

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Anti- and pro-tumor functions of autophagy

6 September 2017

1 reference

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Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Role and regulation of autophagy in cancer

6 September 2017

1 reference

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Autophagic cell death: the story of a misnomer

6 September 2017

1 reference

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Regulation of autophagy by cytoplasmic p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Self-eating and self-killing: crosstalk between autophagy and apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Clonogenic assay of cells in vitro.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Metabolic catastrophe as a means to cancer cell death

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Inhibition of macroautophagy triggers apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Cell death: critical control points

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Ways of dying: multiple pathways to apoptosis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Inhibition of proliferation and induction of apoptosis by tetrandrine in HepG2 cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

6 September 2017

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Defective autophagy associated with LC3 puncta in epothilone-resistant cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Stimulation of autophagy by the p53 target gene Sestrin2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Effects of tetrandrine on apoptosis and radiosensitivity of nasopharyngeal carcinoma cell line CNE.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Reversal of P-glycoprotein-dependent resistance to vinblastine by newly synthesized bisbenzylisoquinoline alkaloids in mouse leukemia P388 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Fangchinoline inhibits glutamate release from rat cerebral cortex nerve terminals (synaptosomes).

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

A novel player in the p53-mediated autophagy: Sestrin2.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Mutant p53 protein localized in the cytoplasm inhibits autophagy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Role of AMP-activated protein kinase in autophagy and proteasome function

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188903

A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes

31 August 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01349.X

Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata

21 January 2018

1 reference

12 December 2020

Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat

1 reference

12 December 2020

Complement-mediated antiinflammatory effect of bisbenzylisoquinoline alkaloid fangchinoline

1 reference

12 December 2020

Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease

1 reference

12 December 2020

The victorin-induced mitochondrial permeability transition precedes cell shrinkage and biochemical markers of cell death, and shrinkage occurs without loss of membrane integrity

1 reference

https://api.crossref.org/works/10.1111/J.1476-5381.2011.01349.X

27 November 2024

Identifiers

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5 September 2017

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5 September 2017

1 reference