HPMA Copolymer-Drug Conjugates with Controlled Tumor-Specific Drug Release (Q38626421)

4 September 2017

title

HPMA Copolymer-Drug Conjugates with Controlled Tumor-Specific Drug Release (English)

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4 September 2017

Karel Ulbrich

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Tomáš Etrych

series ordinal

object named as

Tomáš Etrych

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4 September 2017

Petr Chytil

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4 September 2017

Eva Koziolová

series ordinal

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4 September 2017

Karel Ulbrich

series ordinal

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4 September 2017

publication date

14 August 2017

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Macromolecular Bioscience

4 September 2017

published in

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Impact of nanotechnology on drug delivery.

4 September 2017

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Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution

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Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies

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Direct, controlled synthesis of the nonimmunogenic, hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide) via RAFT in aqueous media.

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N-(2-Hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation

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Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy

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The Potential of Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization as Safe Nanocarrier

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Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging

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Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake

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The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells

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Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro

21 January 2018

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Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia

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N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation

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Polymeric anticancer drugs with pH-controlled activation

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New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties

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Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes

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HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release

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Star-shaped immunoglobulin-containing HPMA-based conjugates with doxorubicin for cancer therapy

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Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

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Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage

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HPMA-based polymer conjugates with drug combination.

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Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis.

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HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases.

21 January 2018

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HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity

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Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification

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Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

21 January 2018

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Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model

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Immunogenicity and immunomodulatory properties of HPMA-based polymers

21 January 2018

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Induction of systemic antitumour resistance with targeted polymers

21 January 2018

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HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy

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Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation.

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Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates

21 January 2018

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Synthesis of poly[N-(2-hydroxypropyl)methacrylamide] conjugates of inhibitors of the ABC transporter that overcome multidrug resistance in doxorubicin-resistant P388 cells in vitro

21 January 2018

1 reference

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Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours

21 January 2018

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Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through an amide or hydrazone bond

21 January 2018

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New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

21 January 2018

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21 January 2018

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Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study

21 January 2018

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Biodegradable Micellar HPMA-Based Polymer-Drug Conjugates with Betulinic Acid for Passive Tumor Targeting.

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Thermoresponsive Polymer Micelles as Potential Nanosized Cancerostatics

21 January 2018

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Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting

21 January 2018

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Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice

21 January 2018

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Isomer-dependent daunomycin release and in vitro antitumour effect of cis-aconityl-daunomycin

21 January 2018

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Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates

21 January 2018

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Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin

21 January 2018

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Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats

21 January 2018

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Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice

21 January 2018

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Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer

21 January 2018

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Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells

21 January 2018

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The coiled coil motif in polymer drug delivery systems

21 January 2018

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Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers

21 January 2018

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Cell Uptake and Trafficking Behavior of Non‐covalent, Coiled‐coil Based Polymer–Drug Conjugates

21 January 2018

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Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MABI.201700209

1 reference

release_vff6h5qq6bctpmxni44ak7nwam

4 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/vff6h5qq6bctpmxni44ak7nwam

mapped directly with Wikidata item

24 November 2022

based on heuristic

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