Current status of pluripotent stem cells: moving the first therapies to the clinic. (Q38590664)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26391880%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Current status of pluripotent stem cells: moving the first therapies to the clinic (English)

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24 February 2020

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24 February 2020

Erin A Kimbrel

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24 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26391880%20AND%20SRC:MED&resulttype=core&format=json

publication date

22 September 2015

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Nature Reviews Drug Discovery

24 February 2020

published in

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24 February 2020

volume

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24 February 2020

issue

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24 February 2020

page(s)

681-692

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Embryonic stem cell lines derived from human blastocysts

24 February 2020

cites work

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Induced pluripotent stem cell lines derived from human somatic cells

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Human induced pluripotent stem cells free of vector and transgene sequences

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A more efficient method to generate integration-free human iPS cells

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A nonviral minicircle vector for deriving human iPS cells

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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

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Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins

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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

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Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration

21 January 2018

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Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application.

21 January 2018

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Embryonic stem cell trials for macular degeneration: a preliminary report

21 January 2018

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Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

21 January 2018

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Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients

21 January 2018

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Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium

21 January 2018

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Efficient generation of retinal progenitor cells from human embryonic stem cells.

21 January 2018

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Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells

21 January 2018

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In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors.

21 January 2018

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Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells.

21 January 2018

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Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells

21 January 2018

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The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.

21 January 2018

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Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

21 January 2018

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A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium

21 January 2018

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Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience

21 January 2018

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Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold

21 January 2018

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Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.

21 January 2018

1 reference

Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells

21 January 2018

1 reference

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays

21 January 2018

1 reference

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity

21 January 2018

1 reference

Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

21 January 2018

1 reference

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

21 January 2018

1 reference

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

21 January 2018

1 reference

RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model

21 January 2018

1 reference

Human pluripotent stem cell-derived cardiomyocytes: response to TTX and lidocain reveals strong cell to cell variability

21 January 2018

1 reference

Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells

21 January 2018

1 reference

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

21 January 2018

1 reference

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

21 January 2018

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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

21 January 2018

1 reference

A scalable system for production of functional pancreatic progenitors from human embryonic stem cells

21 January 2018

1 reference

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

21 January 2018

1 reference

An in vivo model of human small intestine using pluripotent stem cells

21 January 2018

1 reference

Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes

21 January 2018

1 reference

Generation of Hepatocyte-Like Cells from Human Embryonic Stem Cells

21 January 2018

1 reference

Directed differentiation of human embryonic stem cells into functional hepatic cells

21 January 2018

1 reference

Efficient differentiation of functional hepatocytes from human embryonic stem cells

21 January 2018

1 reference

Differentiation and transplantation of human embryonic stem cell-derived hepatocytes

21 January 2018

1 reference

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.

21 January 2018

1 reference

Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.

21 January 2018

1 reference

Robust differentiation of fetal hepatocytes from human embryonic stem cells and iPS

21 January 2018

1 reference

Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells

21 January 2018

1 reference

Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture

21 January 2018

1 reference

Vascularized and functional human liver from an iPSC-derived organ bud transplant

21 January 2018

1 reference

Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy

21 January 2018

1 reference

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

21 January 2018

1 reference

Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions

21 January 2018

1 reference

Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease

21 January 2018

1 reference

Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation

21 January 2018

1 reference

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2.

21 January 2018

1 reference

Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model.

21 January 2018

1 reference

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

21 January 2018

1 reference

Modeling Parkinson's disease using induced pluripotent stem cells

21 January 2018

1 reference

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

21 January 2018

1 reference

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

1 reference

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

1 reference

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis

21 January 2018

1 reference

Modeling familial Alzheimer's disease with induced pluripotent stem cells

21 January 2018

1 reference

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

21 January 2018

1 reference

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

21 January 2018

1 reference

Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons

21 January 2018

1 reference

Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

21 January 2018

1 reference

Induced pluripotent stem cells from a spinal muscular atrophy patient

21 January 2018

1 reference

Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient.

21 January 2018

1 reference

VPA response in SMA is suppressed by the fatty acid translocase CD36.

21 January 2018

1 reference

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

21 January 2018

1 reference

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

21 January 2018

1 reference

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

21 January 2018

1 reference

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

21 January 2018

1 reference

Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers

21 January 2018

1 reference

Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

21 January 2018

1 reference

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

21 January 2018

1 reference

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

21 January 2018

1 reference

Large-scale production of embryonic red blood cells from human embryonic stem cells.

21 January 2018

1 reference

Biologic properties and enucleation of red blood cells from human embryonic stem cells

21 January 2018

1 reference

Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine.

21 January 2018

1 reference

Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells

21 January 2018

1 reference

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

21 January 2018

1 reference

Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells

21 January 2018

1 reference

Scalable generation of universal platelets from human induced pluripotent stem cells.

21 January 2018

1 reference

Platelet bioreactor-on-a-chip

21 January 2018

1 reference

Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions

21 January 2018

1 reference

Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection

21 January 2018

1 reference

Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells.

21 January 2018

1 reference

Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway

21 January 2018

1 reference

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

21 January 2018

1 reference

T lineage differentiation from human embryonic stem cells

21 January 2018

1 reference

Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity

21 January 2018

1 reference

Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity

21 January 2018

1 reference

Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms

21 January 2018

1 reference

Hematopoietic colony-forming cells derived from human embryonic stem cells

21 January 2018

1 reference

Endothelial cells derived from human embryonic stem cells

21 January 2018

1 reference

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.

21 January 2018

1 reference

Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo

21 January 2018

1 reference

VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering

21 January 2018

1 reference

Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo

21 January 2018

1 reference

Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function

21 January 2018

1 reference

Tenascin C promotes hematoendothelial development and T lymphoid commitment from human pluripotent stem cells in chemically defined conditions

21 January 2018

1 reference

Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac

21 January 2018

1 reference

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients.

21 January 2018

1 reference

Targeted gene therapy and cell reprogramming in Fanconi anemia

21 January 2018

1 reference

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

21 January 2018

1 reference

Modeling human lung development and disease using pluripotent stem cells

21 January 2018

1 reference

A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells

21 January 2018

1 reference

Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix.

21 January 2018

1 reference

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

21 January 2018

1 reference

CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury.

21 January 2018

1 reference

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

21 January 2018

1 reference

The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor

21 January 2018

1 reference

Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model

21 January 2018

1 reference

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

21 January 2018

1 reference

Marker succession during the development of keratinocytes from cultured human embryonic stem cells

21 January 2018

1 reference

Differentiation of human embryonic stem cells into clinically amenable keratinocytes in an autogenic environment.

21 January 2018

1 reference

3D In vitro model of a functional epidermal permeability barrier from human embryonic stem cells and induced pluripotent stem cells

21 January 2018

1 reference

Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa

21 January 2018

1 reference

Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa

21 January 2018

1 reference

Derivation of hair-inducing cell from human pluripotent stem cells

21 January 2018

1 reference

Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes

21 January 2018

2 references

21 January 2018

12 December 2020

In vitro pathological modelling using patient-specific induced pluripotent stem cells: the case of progeria.

1 reference

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects

21 January 2018

1 reference

Telomerase protects Werner syndrome lineage-specific stem cells from premature aging.

21 January 2018

1 reference

A GAL4-driver line resource for Drosophila neurobiology

21 January 2018

1 reference

Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome

21 January 2018

1 reference

Treatment of inflammatory diseases with mesenchymal stem cells

21 January 2018

1 reference

MSC-based product characterization for clinical trials: an FDA perspective

21 January 2018

1 reference

The mesenchymal stromal cells dilemma--does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

21 January 2018

1 reference

Replicative senescence of mesenchymal stem cells: a continuous and organized process

21 January 2018

1 reference

Mesenchymal stromal cell migration: possibilities to improve cellular therapy

21 January 2018

1 reference

Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.

21 January 2018

1 reference

Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties

21 January 2018

1 reference

Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis

21 January 2018

1 reference

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis.

21 January 2018

1 reference

Concise review: Induced pluripotent stem cell-derived mesenchymal stem cells: progress toward safe clinical products.

21 January 2018

1 reference

Translation of stem cell research: points to consider in designing preclinical animal studies

21 January 2018

1 reference

Developing safe therapies from human pluripotent stem cells

21 January 2018

1 reference

Assessing iPSC reprogramming methods for their suitability in translational medicine

21 January 2018

1 reference

Roadblocks en route to the clinical application of induced pluripotent stem cells

21 January 2018

1 reference

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

21 January 2018

1 reference

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

31 March 2020

1 reference

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

31 March 2020

1 reference

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

31 March 2020

1 reference

Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential

31 March 2020

1 reference

Human induced pluripotent stem cell-derived B lymphocytes express sIgM and can be generated via a hemogenic endothelium intermediate

31 March 2020

1 reference

Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA

31 March 2020

1 reference

Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma

31 March 2020

1 reference

12 December 2020

Megakaryocyte differentiation events

1 reference

12 December 2020

Generation of functional human pancreatic β cells in vitro

1 reference

12 December 2020

Circulating megakaryocytes and platelet release in the lung

1 reference

12 December 2020

Balancing tissue and tumor formation in regenerative medicine

1 reference

12 December 2020

Stem cell therapy for Parkinson's disease.

1 reference

12 December 2020

Blood-forming potential of vascular endothelium in the human embryo.

1 reference

12 December 2020

Drug screening for ALS using patient-specific induced pluripotent stem cells

1 reference

12 December 2020

Neural stem cell-based treatment for neurodegenerative diseases

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4738

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26391880%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26391880%20AND%20SRC:MED&resulttype=core&format=json