The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor (Q38565718)

4 September 2017

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title

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor (English)

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4 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26269128%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26269128%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Peter B Nunn

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26269128%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Geoffrey J Pilkington

series ordinal

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31 May 2020

publication date

13 August 2015

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4 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26269128%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

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31 May 2020

issue

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31 May 2020

page(s)

3-17

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26269128%20AND%20SRC:MED&resulttype=core&format=json

Comprehensive review on lactate metabolism in human health

31 May 2020

cites work

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Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

21 January 2018

1 reference

Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration

21 January 2018

1 reference

Correlation of lactate dehydrogenase isoenzyme profile with outcome in patients with advanced colorectal cancer treated with chemotherapy and bevacizumab or cediranib: Retrospective analysis of the HORIZON I study.

21 January 2018

1 reference

Metabolic signaling by lactate in the brain

21 January 2018

1 reference

Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

21 January 2018

1 reference

Lactate stimulates endothelial cell migration.

21 January 2018

1 reference

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

21 January 2018

1 reference

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

21 January 2018

1 reference

On the origin of the lactate dehydrogenase induced rate effect.

21 January 2018

1 reference

Gossypol treatment of recurrent adult malignant gliomas

21 January 2018

1 reference

Association between hemoglobin, calcium, and lactate dehydrogenase variability and mortality among metastatic renal cell carcinoma.

21 January 2018

1 reference

Lactate dehydrogenase A silencing in IDH mutant gliomas

21 January 2018

1 reference

In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines

21 January 2018

1 reference

TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

21 January 2018

1 reference

Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients

21 January 2018

1 reference

M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia

21 January 2018

1 reference

FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression

21 January 2018

1 reference

Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status

21 January 2018

1 reference

Brick by brick: metabolism and tumor cell growth

21 January 2018

1 reference

The difference in lactate dehydrogenase activity between pre- and post-mobilization periods is a good indicator of successful stem cell mobilization.

21 January 2018

1 reference

Correlation between serum lactate dehydrogenase and stem cell mobilization.

21 January 2018

1 reference

Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells

21 January 2018

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways

21 January 2018

1 reference

Hypoxic Regulation of Lactate Dehydrogenase A

21 January 2018

1 reference

21 January 2018

1 reference

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

21 January 2018

1 reference

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

21 January 2018

1 reference

Aerobic glycolysis in the human brain is associated with development and neotenous gene expression

21 January 2018

1 reference

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

21 January 2018

1 reference

Increased LDH5 expression is associated with lymph node metastasis and outcome in oral squamous cell carcinoma.

21 January 2018

1 reference

Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-alpha-primase complex

21 January 2018

1 reference

The astrocyte-neuron lactate shuttle: a challenge of a challenge

21 January 2018

1 reference

Lactate: a metabolic key player in cancer

21 January 2018

1 reference

Acidic stress promotes a glioma stem cell phenotype.

21 January 2018

1 reference

ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity

21 January 2018

1 reference

Identification of a gene‐expression signature for predicting lymph node metastasis in patients with early stage cervical carcinoma

21 January 2018

1 reference

Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism

21 January 2018

1 reference

M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo

21 January 2018

1 reference

Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling.

21 January 2018

1 reference

High lactate dehydrogenase 5 expression correlates with high tumoral and stromal vascular endothelial growth factor expression in gastric cancer

21 January 2018

1 reference

Cancer's molecular sweet tooth and the Warburg effect.

21 January 2018

1 reference

Temporal order in mammalian cells. I. The periodic synthesis of lactate dehydrogenase in the cell cycle

21 January 2018

1 reference

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

21 January 2018

1 reference

Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1alpha) pathway, angiogenic factors production and poor prognosis

21 January 2018

1 reference

FOXM1: From cancer initiation to progression and treatment.

21 January 2018

1 reference

Methods for the separation of lactate dehydrogenases and clinical significance of the enzyme

21 January 2018

1 reference

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

21 January 2018

1 reference

Lactate dehydrogenase isoenzymes 1 and 5: differential expression by neoplastic and stromal cells in non-small cell lung cancer and other epithelial malignant tumors

21 January 2018

1 reference

Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer

21 January 2018

1 reference

Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy

21 January 2018

1 reference

Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy

21 January 2018

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Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

1 reference

Endothelial cell response to lactate: implication of PAR modification of VEGF.

21 January 2018

1 reference

LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo.

21 January 2018

1 reference

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 January 2018

1 reference

Enzyme inactivation and inhibition by gossypol

21 January 2018

1 reference

Identification of Putative c-Myc-Responsive Genes: Characterization of rcl, a Novel Growth-Related Gene†

21 January 2018

1 reference

FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells

21 January 2018

1 reference

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

21 January 2018

1 reference

Lactate dehydrogenase 5 expression in Non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis

21 January 2018

1 reference

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

21 January 2018

1 reference

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

21 January 2018

1 reference

Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.

21 January 2018

1 reference

Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation

21 January 2018

1 reference

Lactate dehydrogenase A in cancer: a promising target for diagnosis and therapy

21 January 2018

1 reference

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

1 reference

Synergistic anti-cancer effect of phenformin and oxamate

21 January 2018

1 reference

Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.

21 January 2018

1 reference

NF-κB protein expression associates with (18)F-FDG PET tumor uptake in non-small cell lung cancer: a radiogenomics validation study to understand tumor metabolism

21 January 2018

1 reference

Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.

21 January 2018

1 reference

Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.

21 January 2018

1 reference

Towards improved prognostic scores predicting survival in patients with brain metastases: a pilot study of serum lactate dehydrogenase levels.

21 January 2018

1 reference

Lactic dehydrogenase isoenzymes in cerebrospinal fluid of children with Guillain-Barré syndrome

21 January 2018

1 reference

Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance

21 January 2018

1 reference

Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain

21 January 2018

1 reference

Targeting metabolism to induce cell death in cancer cells and cancer stem cells

21 January 2018

1 reference

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

21 January 2018

1 reference

Ligand binding and protein dynamics in lactate dehydrogenase

21 January 2018

1 reference

Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1

21 January 2018

1 reference

Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice.

21 January 2018

1 reference

Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients

21 January 2018

1 reference

Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase

21 January 2018

1 reference

The expression of hypoxia-inducible factor-1 in primary brain tumors.

21 January 2018

1 reference

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

21 January 2018

1 reference

Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells

21 January 2018

1 reference

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

21 January 2018

1 reference

Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro

21 January 2018

1 reference

Identification of the mouse low-salt-eluting single-stranded DNA-binding protein as a mammalian lactate dehydrogenase-A isoenzyme

21 January 2018

1 reference

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

21 January 2018

1 reference

A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer

21 January 2018

1 reference

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

1 reference

Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway

21 January 2018

1 reference

Influence of oxygen concentration and pH on expression of hypoxia induced genes.

21 January 2018

1 reference

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH.

21 January 2018

1 reference

Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A

21 January 2018

1 reference

Regulation of tumor pH and the role of carbonic anhydrase 9.

21 January 2018

1 reference

Molecular subgroups of medulloblastoma: the current consensus

21 January 2018

1 reference

Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing

21 January 2018

1 reference

Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme

21 January 2018

1 reference

Serial lumbar and ventricle cerebrospinal fluid lactate dehydrogenase activities in patients with leptomeningeal metastases from solid and haematological tumours

21 January 2018

1 reference

Expression of fibroblast growth factor receptor-1 in human glioma and meningioma tissues

21 January 2018

1 reference

Blood lactate is an important energy source for the human brain.

21 January 2018

1 reference

Regional aerobic glycolysis in the human brain

21 January 2018

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

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Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition

21 January 2018

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21 January 2018

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Lactate: mirror and motor of tumor malignancy

21 January 2018

1 reference

LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

21 January 2018

1 reference

Serum S100B, lactate dehydrogenase and brain metastasis are prognostic factors in patients with distant melanoma metastasis and systemic therapy

21 January 2018

1 reference

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

21 January 2018

1 reference

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

21 January 2018

1 reference

Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4.

21 January 2018

1 reference

Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer

21 January 2018

1 reference

Targeting cellular metabolism to improve cancer therapeutics

21 January 2018

1 reference

Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.

21 January 2018

1 reference

S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

21 January 2018

1 reference

Effects of N-terminal deletion mutation on rabbit muscle lactate dehydrogenase

21 January 2018

1 reference

Phosphotyrosine-containing lactate dehydrogenase is restricted to the nuclei of PC12 pheochromocytoma cells

21 January 2018

1 reference

Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol

21 January 2018

1 reference

Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins

21 January 2018

1 reference

Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis

21 January 2018

1 reference

Lactate Dehydrogenase 5 Expression in Operable Colorectal Cancer: Strong Association With Survival and Activated Vascular Endothelial Growth Factor Pathway—A Report of the Tumour Angiogenesis Research Group

21 January 2018

1 reference