IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy (Q38509036)

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scientific article published on 23 August 2006

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English	IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy	scientific article published on 23 August 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy (English)

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Europe PubMed Central

PubMed publication ID

3 September 2017

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author name string

Moon JA

1

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3 September 2017

Kim HT

2

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3 September 2017

Cho IS

3

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3 September 2017

Sheen YY

4

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Europe PubMed Central

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3 September 2017

Kim DK

5

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Europe PubMed Central

PubMed publication ID

3 September 2017

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publication date

23 August 2006

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3 September 2017

Kidney International

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3 September 2017

70

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Europe PubMed Central

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3 September 2017

7

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3 September 2017

1234-1243

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Europe PubMed Central

PubMed publication ID

3 September 2017

TGF-β signalling from cell membrane to nucleus through SMAD proteins

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7 January 2021

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TGF-beta signal transduction

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7 January 2021

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TGF-beta signaling and the fibrotic response

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7 January 2021

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Transforming growth factor-beta and Smad signalling in kidney diseases.

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New insights into TGF-beta-Smad signalling

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Transforming growth factor-beta, cell signaling and cardiovascular disorders

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Role of transforming growth factor Beta in human cancer

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TGF-betal/Smad signaling in prostate cancer

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TGF-beta and fibrosis

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Introduction of a foreign gene into the kidney in vivo: development of glomerulosclerosis by the transfection of genes for PDGF and TGF-beta

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Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung

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Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions

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7 January 2021

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Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis

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Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy

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Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

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In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis

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Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

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Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction

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7 January 2021

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Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice

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Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis

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7 January 2021

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Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor

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7 January 2021

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Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.

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7 January 2021

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Molecular basis of renal fibrosis

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7 January 2021

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Inflammatory mediators and growth factors in obstructive renal injury

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7 January 2021

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Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation

1 reference

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7 January 2021

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Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-beta

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7 January 2021

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Progression in chronic kidney disease.

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7 January 2021

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Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction

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7 January 2021

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Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation

1 reference

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7 January 2021

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Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

1 reference

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7 January 2021

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Time course of cytokine mRNA expression in kidneys of rats with unilateral ureteral obstruction

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7 January 2021

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Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention

1 reference

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7 January 2021

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Characterization of type I receptors for transforming growth factor-beta and activin

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7 January 2021

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Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor

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7 January 2021

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10.1038/SJ.KI.5001775

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Europe PubMed Central

PubMed publication ID

3 September 2017

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https://api.fatcat.wiki/v0/release/5vxihzep25aibpulpcpcc4jnse

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PubMed publication ID

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Europe PubMed Central

PubMed publication ID

3 September 2017

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