Pathological mechanisms in progressive multiple sclerosis (Q38378846)

2 September 2017

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title

Pathological mechanisms in progressive multiple sclerosis (English)

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2 September 2017

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2 September 2017

Don H Mahad

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2 September 2017

Bruce D Trapp

series ordinal

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2 September 2017

publication date

1 February 2015

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2 September 2017

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2 September 2017

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2 September 2017

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2 September 2017

page(s)

183-193

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The immunopathology of multiple sclerosis: an overview

2 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Defining the clinical course of multiple sclerosis: Results of an international survey

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The genetics of multiple sclerosis: an up-to-date review

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Environmental risk factors for multiple sclerosis. Part I: The role of infection

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Alemtuzumab therapy for multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Multiple sclerosis: an immune or neurodegenerative disorder?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The relation between inflammation and neurodegeneration in multiple sclerosis brains.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Disease-specific molecular events in cortical multiple sclerosis lesions.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The human side of microglia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Mitochondrial defects in acute multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Neurological deficits caused by tissue hypoxia in neuroinflammatory disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The distribution of plaques in the cerebrum in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The effect of age on the non-haemin iron in the human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Iron and neurodegeneration in the multiple sclerosis brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Localized grey matter atrophy in multiple sclerosis: a meta-analysis of voxel-based morphometry studies and associations with functional disability.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Transcriptional profiling of microdissected areas of active multiple sclerosis lesions reveals activation of heat shock protein genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Expression profiles of endoplasmic reticulum stress-related molecules in demyelinating lesions and multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

General mechanisms of axonal damage and its prevention

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Mechanisms of disease: sodium channels and neuroprotection in multiple sclerosis-current status

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The measurement and clinical relevance of brain atrophy in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Cortical demyelination and diffuse white matter injury in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Axonal damage in acute multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Axonal transection in the lesions of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Cortical remyelination: a new target for repair therapies in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Inflammatory cortical demyelination in early multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Subpial demyelination in the cerebral cortex of multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Cortical demyelination in PML and MS: Similarities and differences

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Neocortical neuronal, synaptic, and glial loss in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Widespread demyelination in the cerebellar cortex in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Extensive hippocampal demyelination in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Pathological study of spinal cord atrophy in multiple sclerosis suggests limited role of local lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Evidence of early cortical atrophy in MS: relevance to white matter changes and disability

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Remyelination in the CNS: from biology to therapy

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Remyelination is extensive in a subset of multiple sclerosis patients.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Extensive cortical remyelination in patients with chronic multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Demyelination versus remyelination in progressive multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Multiple sclerosis. Pathology of recurrent lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Chemokines and chemokine receptors: multipurpose players in neuroinflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Immunopathology of secondary-progressive multiple sclerosis

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Elevated myeloperoxidase activity in white matter in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

The yin and yang of microglia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Microglia in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Somatic mitochondrial DNA mutations in mammalian aging

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Mitochondrial changes within axons in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Enhanced number and activity of mitochondria in multiple sclerosis lesions

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouse

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Control of autophagy as a therapy for neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b.

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

How mitochondria produce reactive oxygen species

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Iron is a sensitive biomarker for inflammation in multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Imaging cortical lesions in multiple sclerosis with ultra-high-field magnetic resonance imaging

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Increased expression of ER stress- and hypoxia-associated molecules in grey matter lesions in multiple sclerosis

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https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2814%2970256-X

7 January 2021

10.1016/S1474-4422(14)70256-X

Identifiers

DOI

1 reference

2 September 2017

1 reference