Antisense oligonucleotides: is the glass half full or half empty? (Q38341158)

2 September 2017

1 reference

title

Antisense oligonucleotides: is the glass half full or half empty? (English)

1 reference

2 September 2017

Bennett CF

1 reference

2 September 2017

language of work or name

English

0 references

publication date

1 January 1998

1 reference

2 September 2017

published in

Biochemical Pharmacology

1 reference

2 September 2017

1 reference

2 September 2017

1 reference

2 September 2017

page(s)

9-19

1 reference

Therapeutic Applications of Oligonucleotides

2 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Progress in antisense oligonucleotide therapeutics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

The therapeutic potential of antisense oligonucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

7 January 2021

Does antisense exist?

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Stereochemistry of the transesterification step of ribonuclease T 1 .

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Nonionic nucleic acid analogs. Synthesis and characterization of dideoxyribonucleoside methylphosphonates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Comparative activity of alpha- and beta-anomeric oligonucleotides on rabbit beta globin synthesis: inhibitory effect of cap targeted alpha-oligonucleotides.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Phosphorodithioate DNA as a Potential Therapeutic Drug

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Nuclease resistance and antisense activity of modified oligonucleotides targeted to Ha-ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

In vivo stability, disposition and metabolism of a “hybrid” oligonucleotide phosphorothioate in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Renal uptake of an 18-mer phosphorothioate oligonucleotide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Characteristics of oligonucleotide uptake in human keratinocyte cultures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Altered mRNA splicing and inhibition of human E-selectin expression by an antisense oligonucleotide in human umbilical vein endothelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Detection of ribonuclease H-generated mRNA fragments in human leukemia cells following reversible membrane permeabilization in the presence of antisense oligodeoxynucleotides.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Inhibition of human immunodeficiency virus type-1 env expression by C-5 propyne oligonucleotides specific for Rev-response element stem-loop V.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. Effect of actinomycin D and antisense oligonucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Potent and selective inhibition of gene expression by an antisense heptanucleotide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Antisense probing of the human U4/U6 snRNP with biotinylated 2'-OMe RNA oligonucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Oligonucleotides containing 2-aminoadenine and 2-thiothymine act as selectively binding complementary agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Oligonucleosides: synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Inhibition of rabbit beta-globin synthesis by complementary oligonucleotides: identification of mRNA sites sensitive to inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Implication of RNA structure on antisense oligonucleotide hybridization kinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Sequence specific inhibition of human type II phospholipase A2 enzyme activity by phosphorothioate oligonucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

CpG motifs in bacterial DNA trigger direct B-cell activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

RNA Selection: Aptamers achieve the desired recognition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Phosphorothioate antisense oligodeoxynucleotides: questions of specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Sequence context of antisense RelA/NF-kappa B phosphorothioates determines specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Large-scale economic synthesis of antisense phosphorothioate analogues of DNA for preclinical investigations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

DNA fingerprinting by hybridisation to oligonucleotide arrays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Effect of different chemically modified oligodeoxynucleotides on immune stimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Characterization and Modulation of Immune Stimulation by Modified Oligonucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

(2'-5')-Oligo-3'-deoxynucleotides: selective binding to single-stranded RNA but not DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Regulation of endothelial cell adhesion molecule expression with antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Characterization of Binding Sites, Extent of Binding, and Drug Interactions of Oligonucleotides with Albumin

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900214-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(97)00214-1

1 reference

2 September 2017

1 reference