Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding (Q38320275)

2 September 2017

title

Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding (English)

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2 September 2017

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Saxon ML

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2 September 2017

Lee DC

series ordinal

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2 September 2017

language of work or name

English

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publication date

1 October 1999

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

274

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2 September 2017

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2 September 2017

page(s)

28356-28362

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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

2 September 2017

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Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

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Two EGF molecules contribute additively to stabilization of the EGFR dimer

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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

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Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities

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Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

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Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4

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A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

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Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling

21 January 2018

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Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor

21 January 2018

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Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors

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Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation

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A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor

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A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

21 January 2018

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Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

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A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling

21 January 2018

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Disulfide bond structure of human epidermal growth factor receptor.

21 January 2018

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Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

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Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly.

21 January 2018

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Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes

21 January 2018

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Mutations within subdomain II of the extracellular region of epidermal growth factor receptor selectively alter TGF alpha binding

21 January 2018

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Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

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Domain-specific Interactions between the p185neuand Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

21 January 2018

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18 Systematic mutational analyses of protein-protein interfaces

21 January 2018

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Identification of residues of the epidermal growth factor receptor proximal to residue 45 of bound epidermal growth factor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.40.28356

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2 September 2017

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