Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts (Q38308539)

2 September 2017

title

Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts (English)

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2 September 2017

Janice L Walker

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2 September 2017

Paola Castagnino

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2 September 2017

Betty M Chung

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2 September 2017

Marcelo G Kazanietz

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2 September 2017

Richard K Assoian

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2 September 2017

language of work or name

English

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publication date

16 October 2006

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

281

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2 September 2017

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2 September 2017

page(s)

38127-38132

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

2 September 2017

cites work

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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

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New functional activities for the p21 family of CDK inhibitors

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

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WAF1, a potential mediator of p53 tumor suppression

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Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

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Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

21 January 2018

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A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

21 January 2018

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Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling

21 January 2018

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21 January 2018

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Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase

21 January 2018

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p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

21 January 2018

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

21 January 2018

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The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner

21 January 2018

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Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium

21 January 2018

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Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C.

21 January 2018

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The alpha isoform of protein kinase C mediates phorbol ester-induced growth inhibition and p21cip1 induction in HC11 mammary epithelial cells

21 January 2018

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Protein kinase C is involved in the regulation of hairless mRNA expression during mouse keratinocyte differentiation

21 January 2018

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21 January 2018

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21 January 2018

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Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin a gene expression

21 January 2018

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21 January 2018

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Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha

21 January 2018

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Antimitogenesis linked to regulation of Skp2 gene expression

21 January 2018

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Identification of PKC-isoform-specific biological actions using pharmacological approaches

21 January 2018

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

21 January 2018

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Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

21 January 2018

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

21 January 2018

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

21 January 2018

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Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

21 January 2018

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PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.

21 January 2018

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The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation

21 January 2018

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Distinctive activation mechanisms and functions for protein kinase Cdelta

21 January 2018

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PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters

21 January 2018

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Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector

21 January 2018

1 reference

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Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M609622200

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2 September 2017

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