Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase (Q38288501)

16 June 2018

title

Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase (English)

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16 June 2018

author name string

Yoshifumi Sato

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16 June 2018

Tomonori Tsuyama

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16 June 2018

Chinami Sato

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16 June 2018

Md Fazlul Karim

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16 June 2018

Tatsuya Yoshizawa

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16 June 2018

Masahiro Inoue

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16 June 2018

Kazuya Yamagata

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16 June 2018

language of work or name

English

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publication date

31 March 2017

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16 June 2018

Journal of Biological Chemistry

published in

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16 June 2018

volume

292

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16 June 2018

issue

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16 June 2018

page(s)

8716-8728

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16 June 2018

An evolutionarily conserved pathway controls proteasome homeostasis

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Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes

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Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells

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23 June 2018

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23 June 2018

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The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

23 June 2018

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Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.

23 June 2018

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23 June 2018

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Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells

23 June 2018

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AMP-activated kinase regulates cytoplasmic HuR.

23 June 2018

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

23 June 2018

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A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

23 June 2018

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R127W-HNF-4alpha is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1.

23 June 2018

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23 June 2018

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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

23 June 2018

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Protein Kinase A-Dependent Phosphorylation Modulates DNA-Binding Activity of Hepatocyte Nuclear Factor 4

23 June 2018

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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

23 June 2018

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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

23 June 2018

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

23 June 2018

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Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

23 June 2018

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SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

23 June 2018

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Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448099

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448099

5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448099

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448099

Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5448099

Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28364040

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M116.767574

1 reference

16 June 2018

PMC publication ID

5448099

1 reference

16 June 2018

PubMed publication ID

28364040

1 reference

16 June 2018