Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C (Q38269759)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12192065%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C (English)

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12 November 2019

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12 November 2019

Elizabeth D Getzoff

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author name string

Andrew J Gale

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12 November 2019

Xiao Xu

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12 November 2019

Elizabeth D Getzoff

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12 November 2019

John H Griffin

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12 November 2019

publication date

1 September 2002

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12 November 2019

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12 November 2019

volume

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12 November 2019

issue

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12 November 2019

page(s)

2091-2101

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Raster3D: photorealistic molecular graphics

12 November 2019

cites work

2 references

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

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Regulation of blood coagulation

6 September 2017

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Crystal structures of the membrane-binding C2 domain of human coagulation factor V

6 September 2017

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Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va.

6 September 2017

1 reference

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The mechanism of inactivation of human factor V and human factor Va by activated protein C

6 September 2017

1 reference

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Peptide Bond Cleavages and Loss of Functional Activity during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C

6 September 2017

1 reference

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Human coagluation factor V purification and thrombin-catalyzed activation

6 September 2017

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The role of phospholipids and factor Va in the prothrombinase complex

6 September 2017

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Loss of prothrombin and of factor Xa-factor Va interactions upon inactivation of factor Va by activated protein C

6 September 2017

1 reference

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Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism

6 September 2017

1 reference

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Computer-aided model-building strategies for protein design

6 September 2017

1 reference

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Complete cDNA and derived amino acid sequence of human factor V

6 September 2017

1 reference

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The coagulation cascade: initiation, maintenance, and regulation

6 September 2017

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The contribution of bovine Factor V and Factor Va to the activity of prothrombinase

6 September 2017

1 reference

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Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.

6 September 2017

1 reference

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The A2 subunit of factor VIIIa modulates the active site of factor IXa.

23 June 2018

1 reference

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Structural investigation of the A domains of human blood coagulation factor V by molecular modeling

23 June 2018

1 reference

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Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373598

An engineered intersubunit disulfide enhances the stability and DNA binding of the N-terminal domain of lambda repressor.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373598

In vivo formation and stability of engineered disulfide bonds in subtilisin.

23 June 2018

1 reference

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Detection of factor X activation in humans

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373598

Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373598

Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373598

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1110%2FPS.0210002

Directed mutagenesis of dihydrofolate reductase

21 January 2018

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Crossref

https://api.crossref.org/works/10.1110%2FPS.0210002

Three-dimensional model of coagulation factor Va bound to activated protein C

21 January 2018

1 reference

12 December 2020

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

1 reference

12 December 2020

Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways

1 reference

12 December 2020

A model describing the inactivation of factor Va by APC: bond cleavage, fragment dissociation, and product inhibition

1 reference

12 December 2020

The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity

1 reference

12 December 2020

Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation

1 reference

12 December 2020

1 reference

12 December 2020

The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites

1 reference

12 December 2020

Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation

1 reference

12 December 2020

Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis

1 reference

12 December 2020

Activated Protein C Cleavage of Factor Va Leads to Dissociation of the A2 Domain

1 reference

12 December 2020

Characterization of two forms of human factor Va with different cofactor activities

1 reference

12 December 2020

Identifiers

DOI

10.1110/PS.0210002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12192065%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12192065%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

12192065

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12192065%20AND%20SRC:MED&resulttype=core&format=json