From the genome to the phenome: tools to understand the basic biology of Plasmodium falciparum (Q38250222)

1 September 2017

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title

From the genome to the phenome: tools to understand the basic biology of Plasmodium falciparum (English)

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1 September 2017

main subject

Plasmodium falciparum

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author

Geoffrey Ian McFadden

series ordinal

object named as

Geoffrey I McFadden

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1 September 2017

Wesley A J Webster

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1 September 2017

publication date

16 October 2014

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The Journal of Eukaryotic Microbiology

1 September 2017

published in

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1 September 2017

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1 September 2017

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1 September 2017

page(s)

655-671

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Functional expression of ribozymes in Apicomplexa: towards exogenous control of gene expression by inducible RNA-cleavage

1 September 2017

cites work

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Ribozyme cleavage of Plasmodium falciparum gyrase A gene transcript affects the parasite growth

21 January 2018

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Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum

21 January 2018

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Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms.

21 January 2018

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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

21 January 2018

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An FKBP destabilization domain modulates protein levels in Plasmodium falciparum

21 January 2018

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ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption

21 January 2018

1 reference

A genetic screen for attenuated growth identifies genes crucial for intraerythrocytic development of Plasmodium falciparum

21 January 2018

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High-efficiency transformation of Plasmodium falciparum by the lepidopteran transposable element piggyBac

21 January 2018

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piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome

21 January 2018

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CCR4-associated factor 1 coordinates the expression of Plasmodium falciparum egress and invasion proteins

21 January 2018

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A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules

21 January 2018

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In vitro selection of RNA aptamers against a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1.

21 January 2018

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Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

21 January 2018

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PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

21 January 2018

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Engineering a direct and inducible protein-RNA interaction to regulate RNA biology

21 January 2018

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RNAi knock‐downs support roles for the mucin‐like (AeIMUC1) gene and short‐chain dehydrogenase/reductase (SDR) gene in Aedes aegypti susceptibility to Plasmodium gallinaceum

21 January 2018

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The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites

21 January 2018

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The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

21 January 2018

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Genome engineering of Toxoplasma gondii using the site-specific recombinase Cre.

21 January 2018

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Improved properties of FLP recombinase evolved by cycling mutagenesis

21 January 2018

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Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination

21 January 2018

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Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

21 January 2018

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Plate-based transfection and culturing technique for genetic manipulation of Plasmodium falciparum

21 January 2018

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Conditional mutagenesis using site-specific recombination in Plasmodium berghei

21 January 2018

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Malaria drug resistance is associated with defective DNA mismatch repair

21 January 2018

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Recent progress with FKBP-derived destabilizing domains

21 January 2018

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Non-sequence-specific antimalarial activity of oligodeoxynucleotides

21 January 2018

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Global control of gene expression in yeast by the Ccr4-Not complex

21 January 2018

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Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle

21 January 2018

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Clonal conditional mutagenesis in malaria parasites

21 January 2018

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Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

21 January 2018

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Stable transgene expression in Plasmodium falciparum

21 January 2018

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Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.

21 January 2018

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Computational modeling of the Plasmodium falciparum interactome reveals protein function on a genome-wide scale

21 January 2018

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Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum

21 January 2018

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Puromycin-N-acetyltransferase as a selectable marker for use in Plasmodium falciparum.

21 January 2018

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A newly discovered protein export machine in malaria parasites

21 January 2018

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Transformation of malaria parasites by the spontaneous uptake and expression of DNA from human erythrocytes

21 January 2018

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Wherever I may roam: protein and membrane trafficking in P. falciparum-infected red blood cells.

21 January 2018

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The role of N-terminus of Plasmodium falciparum ORC1 in telomeric localization and var gene silencing

21 January 2018

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Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination

21 January 2018

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A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

21 January 2018

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PfCRT and its role in antimalarial drug resistance

21 January 2018

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Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)

21 January 2018

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Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum

21 January 2018

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PTEX is an essential nexus for protein export in malaria parasites

21 January 2018

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A regulatable transgene expression system for cultured Plasmodium falciparum parasites

21 January 2018

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Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

21 January 2018

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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Inhibition of Plasmodium falciparum proliferation in vitro by ribozymes

21 January 2018

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Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

21 January 2018

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Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

21 January 2018

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Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

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Cyclosporin-binding proteins of Plasmodium falciparum

21 January 2018

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Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system.

21 January 2018

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Progress in in silico functional genomics: the malaria Metabolic Pathways database

21 January 2018

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PfMyb1, a Plasmodium falciparum transcription factor, is required for intra-erythrocytic growth and controls key genes for cell cycle regulation

21 January 2018

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Novel nanosomes for gene delivery to Plasmodium falciparum-infected red blood cells

21 January 2018

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

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Comparison of the absolute and relative efficiencies of electroporation-based transfection protocols for Plasmodium falciparum

21 January 2018

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Rapid control of protein level in the apicomplexan Toxoplasma gondii

21 January 2018

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An RNA aptamer that induces transcription

21 January 2018

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Transposon mutagenesis identifies genes essential for Plasmodium falciparum gametocytogenesis

21 January 2018

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Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

21 January 2018

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Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis

21 January 2018

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Rapid recombination among transfected plasmids, chimeric episome formation and trans gene expression in Plasmodium falciparum

21 January 2018

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ATP and luciferase assays to determine the rate of drug action in in vitro cultures of Plasmodium falciparum

21 January 2018

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Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity

21 January 2018

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Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions

21 January 2018

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2A and the auxin-based degron system facilitate control of protein levels in Plasmodium falciparum

21 January 2018

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Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference

21 January 2018

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Plasmodium falciparum biology: analysis of in vitro versus in vivo growth conditions

21 January 2018

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Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

21 January 2018

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A high-throughput method to detect Plasmodium falciparum clones in limiting dilution microplates

21 January 2018

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Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum

21 January 2018

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Transposition of the Drosophila element mariner within the human malaria parasite Plasmodium falciparum

21 January 2018

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A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum

21 January 2018

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Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stage

21 January 2018

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Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum

21 January 2018

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Targeting Plasmodium PI(4)K to eliminate malaria

21 January 2018

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RNA interference (RNAi) inhibits growth of Plasmodium falciparum

21 January 2018

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Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion

21 January 2018

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Modulation of myosin A expression by a newly established tetracycline repressor-based inducible system in Toxoplasma gondii

21 January 2018

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Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators

21 January 2018

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Cloning of Plasmodium falciparum by single-cell sorting

21 January 2018

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A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion

21 January 2018

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Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

21 January 2018

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Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag

21 January 2018

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Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers

21 January 2018

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Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase

21 January 2018

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A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes

21 January 2018

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Whole-genome analysis of Plasmodium spp. Utilizing a new agilent technologies DNA microarray platform.

21 January 2018

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The Arabidopsis DESPERADO/AtWBC11 transporter is required for cutin and wax secretion

21 January 2018

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Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection.

21 January 2018

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Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling

21 January 2018

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A tetracycline-repressible transactivator system to study essential genes in malaria parasites

21 January 2018

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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

21 January 2018

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Inducible knockdown of Plasmodium gene expression using the glmS ribozyme

21 January 2018

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Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection

21 January 2018

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Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

21 January 2018

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The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation

21 January 2018

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Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

21 January 2018

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Serial Analysis of Gene Expression in Plasmodium berghei salivary gland sporozoites

21 January 2018

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Transfection of Plasmodium falciparum

21 January 2018

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A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development

21 January 2018

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Validation of a Plasmodium falciparum parasite transformed with green fluorescent protein for antimalarial drug screening

21 January 2018

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Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

21 January 2018

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Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

21 January 2018

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Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

21 January 2018

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Validation of a modified method for Bxb1 mycobacteriophage integrase-mediated recombination in Plasmodium falciparum by localization of the H-protein of the glycine cleavage complex to the mitochondrion

21 January 2018

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Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

21 January 2018

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Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

21 January 2018

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Plasmodium drug targets outside the genetic control of the parasite

21 January 2018

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Evolution of malaria parasite plastid targeting sequences

21 January 2018

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Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method

21 January 2018

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Plasmodium falciparum signal peptidase is regulated by phosphorylation and required for intra-erythrocytic growth

21 January 2018

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Metabolic maps and functions of the Plasmodium mitochondrion

21 January 2018

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Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase

21 January 2018

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Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes

21 January 2018

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Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum

21 January 2018

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Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

21 January 2018

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Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.

21 January 2018

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Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays

21 January 2018

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Analysis of the molecular mechanisms governing the stage-specific expression of a prototypical housekeeping gene during intraerythrocytic development of P. falciparum

21 January 2018

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Determination of protein subcellular localization in apicomplexan parasites

21 January 2018

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Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine

21 January 2018

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Transfection of Plasmodium falciparum within human red blood cells

21 January 2018

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Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum

21 January 2018

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Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JEU.12176

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1 September 2017

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