Bicarbonate transport in health and disease (Q38255748)

How does carbon dioxide permeate cell membranes? A discussion of concepts, results and methods

21 January 2018

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Genew: the Human Gene Nomenclature Database, 2004 updates

21 January 2018

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Primary structure and transmembrane orientation of the murine anion exchange protein

21 January 2018

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Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter

21 January 2018

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Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium

21 January 2018

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Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter

21 January 2018

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Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter

21 January 2018

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Functional characterization of human NBC4 as an electrogenic Na+-HCO cotransporter (NBCe2).

21 January 2018

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Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family

21 January 2018

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An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel

21 January 2018

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Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger

21 January 2018

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Cloning of a Na+-driven Cl/HCO3exchanger from squid giant fiber lobe

21 January 2018

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Mouse Na+: HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution

21 January 2018

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Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter

21 January 2018

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Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS

21 January 2018

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A new member of the HCO3(-) transporter superfamily is an apical anion exchanger of beta-intercalated cells in the kidney

21 January 2018

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Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney

21 January 2018

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Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity

21 January 2018

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The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization

21 January 2018

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A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells

21 January 2018

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Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6

21 January 2018

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Update on SLC26A3 mutations in congenital chloride diarrhea

21 January 2018

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slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon

21 January 2018

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Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells

21 January 2018

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The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct

21 January 2018

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Pendrin function and regulation in Xenopus oocytes

21 January 2018

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Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition

21 January 2018

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The Pendred syndrome gene encodes a chloride-iodide transport protein

21 January 2018

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Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification

21 January 2018

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Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters

21 January 2018

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SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization

21 January 2018

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Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family

21 January 2018

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Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9

21 January 2018

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Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion

21 January 2018

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Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney

21 January 2018

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SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+

21 January 2018

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Differential contribution of SLC26A9 to Cl(-) conductance in polarized and non-polarized epithelial cells

21 January 2018

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SLC26A9 stimulates CFTR expression and function in human bronchial cell lines

21 January 2018

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Characterization of SLC26A9, facilitation of Cl(-) transport by bicarbonate

21 January 2018

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SLC26A9 is a Cl(-) channel regulated by the WNK kinases

21 January 2018

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Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon

21 January 2018

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Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin

21 January 2018

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Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones

21 January 2018

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Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis

21 January 2018

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Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion

21 January 2018

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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

21 January 2018

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Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion

21 January 2018

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ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition

21 January 2018

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NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation

21 January 2018

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Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases.

21 January 2018

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Ion transport function of SLC4A11 in corneal endothelium

21 January 2018

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Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane

21 January 2018

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Transport of H2S and HS(-) across the human red blood cell membrane: rapid H2S diffusion and AE1-mediated Cl(-)/HS(-) exchange

21 January 2018

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Export by red blood cells of nitric oxide bioactivity

21 January 2018

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BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems

21 January 2018

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Isolation and partial characterization of antibody- and globin-enriched complexes from membranes of dense human erythrocytes

21 January 2018

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Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase

21 January 2018

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Structure of the membrane domain of human erythrocyte anion exchanger 1 revealed by electron crystallography

21 January 2018

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Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains

21 January 2018

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X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

21 January 2018

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Modification of a carboxyl group that appears to cross the permeability barrier in the red blood cell anion transporter

21 January 2018

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The substrate anion selectivity filter in the human erythrocyte Cl-/HCO3- exchange protein, AE1.

21 January 2018

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Novel topology in C-terminal region of the human plasma membrane anion exchanger, AE1.

21 January 2018

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Topology models of anion exchanger 1 that incorporate the anti-parallel V-shaped motifs found in the EM structure.

21 January 2018

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Structural model of the anion exchanger 1 (SLC4A1) and identification of transmembrane segments forming the transport site.

21 January 2018

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Structure and mechanism of the uracil transporter UraA

21 January 2018

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Mis-trafficking of bicarbonate transporters: implications to human diseases

21 January 2018

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A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells

21 January 2018

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Regions of human kidney anion exchanger 1 (kAE1) required for basolateral targeting of kAE1 in polarised kidney cells: mis-targeting explains dominant renal tubular acidosis (dRTA).

21 January 2018

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Mutation conferring apical-targeting motif on AE1 exchanger causes autosomal dominant distal RTA.

21 January 2018

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Band 3 mutations, distal renal tubular acidosis, and Southeast Asian ovalocytosis

21 January 2018

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Defective anion transport activity of the abnormal band 3 in hereditary ovalocytic red blood cells

21 January 2018

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Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton

21 January 2018

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Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton

21 January 2018

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Regulation of AE2-mediated Cl- transport by intracellular or by extracellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytoplasmic domain

21 January 2018

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The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+K(+)-ATPase rather than with basolateral anion exchanger AE2

21 January 2018

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Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric

21 January 2018

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Role of NBCe1 and AE2 in secretory ameloblasts

21 January 2018

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The anion exchanger Ae2 is required for enamel maturation in mouse teeth

21 January 2018

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Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger

21 January 2018

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Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy

21 January 2018

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Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3.

21 January 2018

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Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold

21 January 2018

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Blindness caused by deficiency in AE3 chloride/bicarbonate exchanger

21 January 2018

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Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heart

21 January 2018

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Resistance to cardiomyocyte hypertrophy in ae3-/- mice, deficient in the AE3 Cl-/HCO3- exchanger

21 January 2018

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Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure

21 January 2018

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Loss of the AE3 Cl(-)/HCO(-) 3 exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart

21 January 2018

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Involvement of AE3 isoform of Na(+)-independent Cl(-)/HCO(3)(-) exchanger in myocardial pH(i) recovery from intracellular alkalization

21 January 2018

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The stoichiometry of the electrogenic sodium bicarbonate cotransporter NBC1 is cell-type dependent

21 January 2018

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Phosphorylation of Ser982 in the sodium bicarbonate cotransporter kNBC1 shifts the HCO3-: Na+ stoichiometry from 3:1 to 2:1 in murine proximal tubule cells

21 January 2018

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Missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis

21 January 2018

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Cloning and functional expression of a human kidney Na+:HCO3- cotransporter

21 January 2018

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Structural and Functional Characterization of the C-terminal Transmembrane Region of NBCe1-A

21 January 2018

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Topology of NBCe1 protein transmembrane segment 1 and structural effect of proximal renal tubular acidosis (pRTA) S427L mutation

21 January 2018

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Entry to "formula tunnel" revealed by SLC4A4 human mutation and structural model

21 January 2018

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A substrate access tunnel in the cytosolic domain is not an essential feature of the solute carrier 4 (SLC4) family of bicarbonate transporters

21 January 2018

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Oligomeric structure and minimal functional unit of the electrogenic sodium bicarbonate cotransporter NBCe1-A.

21 January 2018

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Differential expression of electrogenic NBC1 (SLC4A4) variants in rat kidney and pancreas

21 January 2018

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Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities

21 January 2018

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Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis

21 January 2018

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Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities

21 January 2018

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Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury

21 January 2018

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Molecular mechanisms underlying the corneal endothelial pump

21 January 2018

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The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition.

21 January 2018

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Identification and properties of a novel variant of NBC4 (Na(+)/HCO(3)- co-transporter 4) that is predominantly expressed in the choroid plexus.

21 January 2018

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Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

21 January 2018

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Cerebrospinal fluid secretion by the choroid plexus

21 January 2018

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Positional identification of hypertension susceptibility genes on chromosome 2.

21 January 2018

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Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter

21 January 2018

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Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis

21 January 2018

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Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons.

21 January 2018

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The electroneutral sodium/bicarbonate cotransporter containing an amino terminal 123-amino-acid cassette is expressed predominantly in the heart

21 January 2018

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Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis

21 January 2018

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Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family

21 January 2018

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Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3

21 January 2018

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Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2

21 January 2018

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Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice.

21 January 2018

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Na+-dependent HCO3- import by the slc4a10 gene product involves Cl- export

21 January 2018

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Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability

21 January 2018

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Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina

21 January 2018

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The sodium-driven chloride/bicarbonate exchanger in presynaptic terminals

21 January 2018

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Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO₃⁻ exchanger Slc4a8.

21 January 2018

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The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

21 January 2018

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Renal β-intercalated cells maintain body fluid and electrolyte balance

21 January 2018

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AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct

21 January 2018

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Renal intercalated cells are rather energized by a proton than a sodium pump

21 January 2018

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Structure, function, and trafficking of SLC4 and SLC26 anion transporters

21 January 2018

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Conserved dimeric subunit stoichiometry of SLC26 multifunctional anion exchangers

21 January 2018

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STAS domain structure and function

21 January 2018

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Metabolon disruption: a mechanism that regulates bicarbonate transport

21 January 2018

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Gating of CFTR by the STAS domain of SLC26 transporters

21 January 2018

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Regulation of electroneutral NaCl absorption by the small intestine

21 January 2018

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A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis

21 January 2018

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Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas

21 January 2018

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Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3.

21 January 2018

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Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion

21 January 2018

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Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease

21 January 2018

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Origins and frequencies of SLC26A4 (PDS) mutations in east and south Asians: global implications for the epidemiology of deafness

21 January 2018

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A mutation in PDS causes non-syndromic recessive deafness

21 January 2018

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Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)

21 January 2018

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Heterogeneity in the processing defect of SLC26A4 mutants

21 January 2018

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Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome

21 January 2018

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Influence of dietary iodine deficiency on the thyroid gland in Slc26a4-null mutant mice.

21 January 2018

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SLC26A4/PDS genotype-phenotype correlation in hearing loss with enlargement of the vestibular aqueduct (EVA): evidence that Pendred syndrome and non-syndromic EVA are distinct clinical and genetic entities

21 January 2018

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SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.

21 January 2018

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Deletion of the Cl-/HCO3- exchanger pendrin downregulates calcium-absorbing proteins in the kidney and causes calcium wasting

21 January 2018

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Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct

21 January 2018

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Slc26a6: a cardiac chloride-hydroxyl exchanger and predominant chloride-bicarbonate exchanger of the mouse heart

21 January 2018

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Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity

21 January 2018

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Renal and intestinal transport defects in Slc26a6-null mice

21 January 2018

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Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6

21 January 2018

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Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5

21 January 2018

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Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice

21 January 2018

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Identification of an apical Cl-/HCO-3 exchanger in rat kidney proximal tubule

21 January 2018

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SLC26A7 is a Cl- channel regulated by intracellular pH

21 January 2018

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SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation

21 January 2018

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The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion

21 January 2018

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Slc26a9--anion exchanger, channel and Na+ transporter

21 January 2018

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Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach

21 January 2018

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SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia

21 January 2018

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Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney

21 January 2018

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Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H⁺-ATPase

21 January 2018

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Carbonic anhydrases and their interplay with acid/base-coupled membrane transporters

21 January 2018

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Complexes of sequential metabolic enzymes

21 January 2018

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Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1

21 January 2018

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Localization of the Cl-/HCO3- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II

21 January 2018

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Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger

21 January 2018

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Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer

21 January 2018

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Cytosolic H+ microdomain developed around AE1 during AE1-mediated Cl-/HCO3- exchange

21 January 2018

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The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV

21 January 2018

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Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters

21 January 2018

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Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.

21 January 2018

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Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase

21 January 2018

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Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1.

21 January 2018

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Nonenzymatic augmentation of lactate transport via monocarboxylate transporter isoform 4 by carbonic anhydrase II.

21 January 2018

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Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.

21 January 2018

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Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.

21 January 2018

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Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase

21 January 2018

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Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells

21 January 2018

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Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter

21 January 2018

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The functional and physical relationship between the DRA bicarbonate transporter and carbonic anhydrase II

21 January 2018

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Effect of human carbonic anhydrase II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes

21 January 2018

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Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1.

21 January 2018

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Disrupting proton dynamics and energy metabolism for cancer therapy

21 January 2018

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New strategies for targeting the hypoxic tumour microenvironment in breast cancer

21 January 2018

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Regulation and roles of bicarbonate transporters in cancer

21 January 2018

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Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK.

21 January 2018

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Contribution of Na+,HCO3(-)-cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7).

21 January 2018

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Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter

21 January 2018

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SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts

21 January 2018

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A biochemical framework for SLC4A11, the plasma membrane protein defective in corneal dystrophies

21 January 2018

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Arabidopsis boron transporter for xylem loading.

21 January 2018

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Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2).

21 January 2018

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SLC4A11 mutations in Fuchs endothelial corneal dystrophy.

21 January 2018

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Specificity of anion exchange mediated by mouse Slc26a6

21 January 2018

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Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells

21 January 2018

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