Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines. (Q38245652)

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15 February 2020

title

Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines (English)

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15 February 2020

0 references

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15 February 2020

Mariagrazia Pizza

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15 February 2020

Ugo D'Oro

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15 February 2020

Maria Scarselli

series ordinal

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publication date

3 September 2014

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Expert Review of Vaccines

15 February 2020

published in

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volume

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issue

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page(s)

1191-1204

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Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model

15 February 2020

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Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon

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The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein.

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Characterization of the carbohydrate binding and ADP-ribosyltransferase activities of chemically detoxified pertussis toxins

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Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4.

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Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin

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Hybrid genes over-express pertactin from Bordetella pertussis

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Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation

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Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28.

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Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells

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Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10-dependent mechanisms.

21 January 2018

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Cell-surface bound pertussis toxin induces polyclonal T cell responses with high levels of interferon-gamma in the absence of interleukin-12.

21 January 2018

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Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways

21 January 2018

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Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.

21 January 2018

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Phase I clinical trial of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin combined with FHA and 69 kDa

21 January 2018

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21 January 2018

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10.1586/14760584.2014.942641

21 January 2018

Identifiers

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15 February 2020

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