The role of oligodendroglial dysfunction in amyotrophic lateral sclerosis (Q38237223)

31 August 2017

title

The role of oligodendroglial dysfunction in amyotrophic lateral sclerosis (English)

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amyotrophic lateral sclerosis

31 August 2017

main subject

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Wim Robberecht

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31 August 2017

Annelies Nonneman

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31 August 2017

Ludo Van Den Bosch

series ordinal

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31 August 2017

language of work or name

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1 January 2014

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Neurodegenerative disease management

31 August 2017

published in

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31 August 2017

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31 August 2017

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31 August 2017

page(s)

223-239

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Myelination and support of axonal integrity by glia

31 August 2017

cites work

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Axonal selection and myelin sheath generation in the central nervous system

21 January 2018

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Oligodendroglia metabolically support axons and contribute to neurodegeneration.

21 January 2018

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Oligodendroglia: metabolic supporters of axons

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State of play in amyotrophic lateral sclerosis genetics

21 January 2018

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

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Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 January 2018

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Exome sequencing reveals VCP mutations as a cause of familial ALS

21 January 2018

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

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Onset and progression in inherited ALS determined by motor neurons and microglia

21 January 2018

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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

21 January 2018

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Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation

21 January 2018

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Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation

21 January 2018

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TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions

21 January 2018

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Axon-glial signaling and the glial support of axon function

21 January 2018

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Axon-glia interaction and membrane traffic in myelin formation

21 January 2018

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The local differentiation of myelinated axons at nodes of Ranvier

21 January 2018

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Regulation of oligodendrocyte development and myelination by glucose and lactate

21 January 2018

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Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex

21 January 2018

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21 January 2018

Oligodendrocyte origins

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Origins of spinal cord oligodendrocytes: possible developmental and evolutionary relationships with motor neurons.

21 January 2018

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From neural stem cells to myelinating oligodendrocytes

21 January 2018

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Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

21 January 2018

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NG2 cells: Properties, progeny and origin

21 January 2018

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The oligodendrocyte precursor cell in health and disease

21 January 2018

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Myelin restoration: progress and prospects for human cell replacement therapies.

21 January 2018

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Individual axons regulate the myelinating potential of single oligodendrocytes in vivo

21 January 2018

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21 January 2018

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Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling

21 January 2018

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NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.

21 January 2018

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Synantocytes: new functions for novel NG2 expressing glia

21 January 2018

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Neuron-glia synapses in the brain.

21 January 2018

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The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain

21 January 2018

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Demyelination and remyelination after spinal cord injury

21 January 2018

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The response of adult oligodendrocyte progenitors to demyelination in EAE.

21 January 2018

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The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS

21 January 2018

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NG2-glia as multipotent neural stem cells: fact or fantasy?

21 January 2018

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Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo

21 January 2018

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PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice.

21 January 2018

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NG2 cells generate both oligodendrocytes and gray matter astrocytes.

21 January 2018

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NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord

21 January 2018

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CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

21 January 2018

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Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons

21 January 2018

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Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation

21 January 2018

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Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury

21 January 2018

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Age-dependent fate and lineage restriction of single NG2 cells

21 January 2018

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.

21 January 2018

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TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation

21 January 2018

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Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

21 January 2018

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Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.

21 January 2018

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Apoptosis: controlled demolition at the cellular level

21 January 2018

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ATP mediates rapid microglial response to local brain injury in vivo

21 January 2018

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Adult glial precursor proliferation in mutant SOD1G93A mice

21 January 2018

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NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system

21 January 2018

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Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice

21 January 2018

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Myelin basic protein: a multifunctional protein

21 January 2018

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Poor and protracted myelination as a contributory factor to neurodegenerative disorders

21 January 2018

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Oligodendrocytes use lactate as a source of energy and as a precursor of lipids

21 January 2018

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Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies.

21 January 2018

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Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes

21 January 2018

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CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species

21 January 2018

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Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes

21 January 2018

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Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

21 January 2018

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Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis

21 January 2018

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Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitors

21 January 2018

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Microglia: neuroprotective and neurotrophic cells in the central nervous system

21 January 2018

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Intracellular events mediating insulin-like growth factor I-induced oligodendrocyte development: modulation by cyclic AMP.

21 January 2018

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CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo

21 January 2018

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How factors secreted from astrocytes impact myelin repair

21 January 2018

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

21 January 2018

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Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

21 January 2018

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Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords of transgenic mice with a G93A mutant SOD1 gene

21 January 2018

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Oxidative stress disrupts oligodendrocyte maturation

21 January 2018

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Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

21 January 2018

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The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

21 January 2018

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Amyotrophic lateral sclerosis and excitotoxicity: from pathological mechanism to therapeutic target.

21 January 2018

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Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes.

21 January 2018

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Multiple classes of the oligodendrocyte lineage are highly vulnerable to excitotoxicity

21 January 2018

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NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury

21 January 2018

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The complex world of oligodendroglial differentiation inhibitors

21 January 2018

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Enhancing remyelination in disease--can we wrap it up?

21 January 2018

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Notch receptor activation inhibits oligodendrocyte differentiation

21 January 2018

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Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation

21 January 2018

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Notch: a new player in MS mechanisms

21 January 2018

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Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration.

21 January 2018

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HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction

21 January 2018

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Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

21 January 2018

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Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination

21 January 2018

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Nogo-A: Multiple Roles in CNS Development, Maintenance, and Disease

21 January 2018

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Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis.

21 January 2018

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Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis.

21 January 2018

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The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination

21 January 2018

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ID2: A negative transcription factor regulating oligodendroglia differentiation

21 January 2018

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The Id4 HLH protein and the timing of oligodendrocyte differentiation

21 January 2018

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Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings

21 January 2018

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Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice

21 January 2018

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Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

21 January 2018

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Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination

21 January 2018

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Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

21 January 2018

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Axonal damage in acute multiple sclerosis lesions

21 January 2018

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Axonal transection in the lesions of multiple sclerosis

21 January 2018

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Axonal swellings and degeneration in mice lacking the major proteolipid of myelin

21 January 2018

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Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.

21 January 2018

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Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.

21 January 2018

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Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination.

21 January 2018

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Targeted ablation of oligodendrocytes triggers axonal damage

21 January 2018

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Myelin loss does not lead to axonal degeneration in a long-lived model of chronic demyelination

21 January 2018

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Does oligodendrocyte survival depend on axons?

21 January 2018

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Axonal control of oligodendrocyte development

21 January 2018

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Oligodendrocyte survival in Wallerian degeneration

21 January 2018

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Two temporal stages of oligodendroglial response to excitotoxic lesion in the gray matter of the adult rat brain

21 January 2018

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NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression

21 January 2018

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Metabolic signaling by lactate in the brain

21 January 2018

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Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation

21 January 2018

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Evidence that perinatal and adult NG2-glia are not conventional oligodendrocyte progenitors and do not depend on axons for their survival

21 January 2018

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Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

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Amyotrophic lateral sclerosis

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21 January 2018

Identifiers

DOI

10.2217/NMT.14.21

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31 August 2017

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