Structure of Class B GPCRs: new horizons for drug discovery (Q38195892)

30 August 2017

1 reference

title

Structure of Class B GPCRs: new horizons for drug discovery (English)

1 reference

G protein-coupled receptor

30 August 2017

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Andrea Bortolato

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Andrew S Doré

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Kaspar Hollenstein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Benjamin G Tehan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jonathan S Mason

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

0 references

publication date

1 July 2014

1 reference

British Journal of Pharmacology

30 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

171

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10 June 2020

issue

1 reference

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10 June 2020

page(s)

3132-3145

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

Unifying family A GPCR theories of activation

10 June 2020

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6 September 2017

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Insights into the structure of class B GPCRs

6 September 2017

1 reference

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Structure of class B GPCR corticotropin-releasing factor receptor 1

6 September 2017

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Structure of the human glucagon class B G-protein-coupled receptor

6 September 2017

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Structure of the human smoothened receptor bound to an antitumour agent

6 September 2017

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Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies

6 September 2017

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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

6 September 2017

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Molecular signatures of G-protein-coupled receptors

6 September 2017

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Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism

6 September 2017

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Structure-function of the G protein-coupled receptor superfamily

6 September 2017

1 reference

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Molecular basis for negative regulation of the glucagon receptor

6 September 2017

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An update in incretin-based therapy: a focus on glucagon-like peptide-1 receptor agonists

6 September 2017

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Targeting the glucagon receptor family for diabetes and obesity therapy

6 September 2017

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The corticotropin releasing factor system in the kidney: perspectives for novel therapeutic intervention in nephrology

6 September 2017

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The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development

6 September 2017

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New insights from structural biology into the druggability of G protein-coupled receptors.

6 September 2017

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Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

6 September 2017

1 reference

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Discovery of 1,2,4-Triazine Derivatives as Adenosine A 2A Antagonists using Structure Based Drug Design

6 September 2017

1 reference

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The use of GPCR structures in drug design.

6 September 2017

1 reference

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Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine

6 September 2017

1 reference

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

6 September 2017

1 reference

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Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?

6 September 2017

1 reference

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Pramlintide and the treatment of diabetes: a review of the data since its introduction

6 September 2017

1 reference

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Structural insights into adrenergic receptor function and pharmacology

6 September 2017

1 reference

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Growth hormone axis treatments for HIV-associated lipodystrophy: a systematic review of placebo-controlled trials

6 September 2017

1 reference

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VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies

6 September 2017

1 reference

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Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges

6 September 2017

1 reference

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Oral salmon calcitonin--pharmacology in osteoporosis

6 September 2017

1 reference

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Corticotropin-releasing factor receptors and urocortins, links between the brain and the heart

6 September 2017

1 reference

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Drugability of extracellular targets: discovery of small molecule drugs targeting allosteric, functional, and subunit-selective sites on GPCRs and ion channels

6 September 2017

1 reference

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

6 September 2017

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Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis

6 September 2017

1 reference

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Small-molecule agonists for the glucagon-like peptide 1 receptor

6 September 2017

1 reference

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A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice

6 September 2017

1 reference

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Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

6 September 2017

1 reference

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Hydrogen bonding interactions of covalently bonded fluorine atoms: from crystallographic data to a new angular function in the GRID force field

6 September 2017

1 reference

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High-throughput modeling of human G-protein coupled receptors: amino acid sequence alignment, three-dimensional model building, and receptor library screening

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

CRF and CRF receptors: role in stress responsivity and other behaviors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

Emerging functions for tuberoinfundibular peptide of 39 residues.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

Constitutive Activity of Glucagon Receptor Mutants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080969

23 June 2018

1 reference

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Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FBPH.12689

RAMP-ing up class-B GPCR ECD structural coverage

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24628305

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BPH.12689

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

24628305

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24628305%20AND%20SRC:MED&resulttype=core&format=json