Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology (Q38183464)

30 August 2017

title

Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology (English)

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30 August 2017

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30 August 2017

William Charles Earnshaw

William C Earnshaw

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Natalay Kouprina

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30 August 2017

Hiroshi Masumoto

series ordinal

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30 August 2017

Vladimir Larionov

series ordinal

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30 August 2017

language of work or name

English

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publication date

30 January 2014

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Expert Opinion on Drug Delivery

30 August 2017

published in

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30 August 2017

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30 August 2017

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30 August 2017

page(s)

517-535

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Virus-mediated gene delivery for human gene therapy

30 August 2017

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Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

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Delivery of large genomic DNA inserts >100 kb using HSV-1 amplicons.

21 January 2018

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Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes

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Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

21 January 2018

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Viral-mediated gene therapy for the muscular dystrophies: successes, limitations and recent advances

21 January 2018

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Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

21 January 2018

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Medicine. Gene therapy that works

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The AAV vector toolkit: poised at the clinical crossroads

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Adeno-associated virus vectorology, manufacturing, and clinical applications

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Adeno-associated virus mediated gene therapy for retinal degenerative diseases.

21 January 2018

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Gene therapy of primary T cell immunodeficiencies

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Gene therapy for primary immunodeficiencies: Part 1.

21 January 2018

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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

21 January 2018

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Gene therapy for leukodystrophies

21 January 2018

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Strategies for engineering human chromosomes with therapeutic potential

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human artificial chromosomes: potential applications and clinical considerations

21 January 2018

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Transfer of human artificial chromosome vectors into stem cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human artificial chromosomes for gene delivery and the development of animal models

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Construction and use of a bottom-up HAC vector for transgene expression.

21 January 2018

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A new generation of human artificial chromosomes for functional genomics and gene therapy

21 January 2018

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A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector

21 January 2018

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Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

The transfer of human artificial chromosomes via cryopreserved microcells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Exploiting the yeast Saccharomyces cerevisiae for the study of the organization and evolution of complex genomes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Refined human artificial chromosome vectors for gene therapy and animal transgenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Increased ratio of targeted to random integration after transfection of chicken B cell lines.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Generation of an approximately 2.4 Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Dissecting the centromere of the human Y chromosome with cloned telomeric DNA.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Efficient modification of a human chromosome by telomere-directed truncation in high homologous recombination-proficient chicken DT40 cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Construction of a novel human artificial chromosome vector for gene delivery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation

21 January 2018

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Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes

21 January 2018

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A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors.

21 January 2018

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Formation of de novo centromeres and construction of first-generation human artificial microchromosomes

21 January 2018

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Construction of YAC-based mammalian artificial chromosomes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Stable gene expression from a mammalian artificial chromosome

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Inactivation of a human kinetochore by specific targeting of chromatin modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human artificial chromosome with a conditional centromere for gene delivery and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human artificial chromosomes constructed using the bottom-up strategy are stably maintained in mitosis and efficiently transmissible to progeny mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Functional human CFTR produced by a stable minichromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Escherichia coli-cloned CFTR loci relevant for human artificial chromosome therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

An induced pluripotent stem cell-mediated and integration-free factor VIII expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Cell to cell transfer of the chromatin-packaged human beta-globin gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Input DNA ratio determines copy number of the 33 kb Factor IX gene on de novo human artificial chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

A highly stable and nonintegrated human artificial chromosome (HAC) containing the 2.4 Mb entire human dystrophin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Complete genetic correction of ips cells from Duchenne muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Functional complementation of a genetic deficiency with human artificial chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Antigen-specific human polyclonal antibodies from hyperimmunized cattle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Controlled transgene dosage and PAC-mediated transgenesis in mice using a chromosomal vector.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Manipulating transgenes using a chromosome vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Integration-free iPS cells engineered using human artificial chromosome vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Stem cell-mediated transfer of a human artificial chromosome ameliorates muscular dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle muscular dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Stem cell therapies for muscle disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Specific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

TAR cloning: insights into gene function, long-range haplotypes and genome structure and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Optimum conditions for selective isolation of genes from complex genomes by transformation-associated recombination cloning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human tRNA genes function as chromatin insulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

tRNA genes protect a reporter gene from epigenetic silencing in mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Protecting a transgene expression from the HAC-based vector by different chromatin insulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Induced pluripotent stem cells: opportunities and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Generation of mouse induced pluripotent stem cells without viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Induced pluripotent stem cells generated without viral integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Generation of induced pluripotent stem cells using recombinant proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

The development of pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Selective ablation of human embryonic stem cells expressing a "suicide" gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Protecting against wayward human induced pluripotent stem cells with a suicide gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Mechanisms of chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Mutability and mutational spectrum of chromosome transmission fidelity genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

The generation of stable, high MAb expressing CHO cell lines based on the artificial chromosome expression (ACE) technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

Construction of artificial chromosomes in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.882314

10.1517/17425247.2014.882314

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference