Pharmacological inhibition of actin assembly to target tumor cell motility (Q38160173)

30 August 2017

title

Pharmacological inhibition of actin assembly to target tumor cell motility (English)

1 reference

30 August 2017

Robert Grosse

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Alexander Nürnberg

1 reference

30 August 2017

Alina Kollmannsperger

series ordinal

1 reference

30 August 2017

publication date

1 January 2014

1 reference

Reviews of Physiology, Biochemistry and Pharmacology

30 August 2017

published in

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30 August 2017

volume

166

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30 August 2017

page(s)

23-42

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The Gab1 scaffold regulates RTK-dependent dorsal ruffle formation through the adaptor Nck.

30 August 2017

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Hyaluronan-CD44 interaction with neural Wiskott-Aldrich syndrome protein (N-WASP) promotes actin polymerization and ErbB2 activation leading to beta-catenin nuclear translocation, transcriptional up-regulation, and cell migration in ovarian tumor ce

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A nucleator arms race: cellular control of actin assembly

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HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1.

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A perspective on cancer cell metastasis

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Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

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Gene profiling of Graffi murine leukemia virus-induced lymphoid leukemias: identification of leukemia markers and Fmn2 as a potential oncogene

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Migrastatin analogues target fascin to block tumour metastasis

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Actin nucleation and elongation factors: mechanisms and interplay

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A transcription co-factor integrates cell adhesion and motility with the p53 response.

21 January 2018

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Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension

21 January 2018

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N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells

21 January 2018

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Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease

21 January 2018

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Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages

21 January 2018

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Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.

21 January 2018

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New mechanisms and functions of actin nucleation

21 January 2018

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The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis

21 January 2018

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Isoform-selective chemical inhibition of mDia-mediated actin assembly.

21 January 2018

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N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

21 January 2018

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The ARP2/3 complex: an actin nucleator comes of age

21 January 2018

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An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Mechanism and function of formins in the control of actin assembly

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics

21 January 2018

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The roles of fascins in health and disease

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Mammalian Rho GTPases: new insights into their functions from in vivo studies

21 January 2018

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Phylogenetic analysis of the formin homology 2 domain

21 January 2018

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Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex

21 January 2018

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Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

21 January 2018

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β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability

21 January 2018

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Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

21 January 2018

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Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway.

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Molecular details of formin-mediated actin assembly

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Self-assembly of filopodia-like structures on supported lipid bilayers

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways.

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Down-regulation of formin-like 2 predicts poor prognosis in hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

21 January 2018

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Degrading devices: invadosomes in proteolytic cell invasion

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice

21 January 2018

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https://api.crossref.org/works/10.1007%2F112_2013_16

Cell regulation by the Apc protein Apc as master regulator of epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Nucleating actin for invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Linking actin dynamics and gene transcription to drive cellular motile functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Get off my back! Rapid receptor internalization through circular dorsal ruffles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Involvement of Arp2/3 complex in the process of colorectal carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Physical mechanisms of signal integration by WASP family proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Arp2/3 complex is bound and activated by two WASP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Actin, a central player in cell shape and movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Role of formins in actin assembly: nucleation and barbed-end association

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Actin-bundling proteins in cancer progression at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Overexpression of FMNL2 is closely related to metastasis of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

p53-cofactor JMY is a multifunctional actin nucleation factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F112_2013_16

Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.1130

Identifiers

DOI

10.1007/112_2013_16

1 reference

30 August 2017

1 reference