Bile acid receptors as targets for drug development. (Q38132058)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23982684%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Bile acid receptors as targets for drug development (English)

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8 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23982684%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Michael Trauner

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8 March 2020

Peter L M Jansen

series ordinal

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8 March 2020

language of work or name

English

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publication date

27 August 2013

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Nature Reviews Gastroenterology & Hepatology

8 March 2020

published in

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8 March 2020

volume

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8 March 2020

issue

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8 March 2020

page(s)

55-67

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The enzymes, regulation, and genetics of bile acid synthesis

8 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Bile salt biotransformations by human intestinal bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

21 January 2018

Bile acid transporters

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Studies of intestinal digestion and absorption in the human

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Endocrine functions of bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Vitamin D receptor as an intestinal bile acid sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of membrane-type receptor for bile acids (M-BAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A G protein-coupled receptor responsive to bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Expression and activation of the farnesoid X receptor in the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Proteomics for the discovery of nuclear bile acid receptor FXR targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

FXR: a metabolic regulator and cell protector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Regulation of bile acid synthesis by fat-soluble vitamins A and D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Co-receptor requirements for fibroblast growth factor-19 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of a hormonal basis for gallbladder filling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The Receptor Tyrosine Kinase FGFR4 Negatively Regulates NF-kappaB Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

TGR5-mediated bile acid sensing controls glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Role of CAR and PXR in xenobiotic sensing and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The PXR is a drug target for chronic inflammatory liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

FXR and PXR: potential therapeutic targets in cholestasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Minireview: vitamin D receptor: new assignments for an already busy receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A novel bile acid-activated vitamin D receptor signaling in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Antiatherosclerotic effect of farnesoid X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A natural product that lowers cholesterol as an antagonist ligand for FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Effects of FXR in foam-cell formation and atherosclerosis development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

EASL Clinical Practice Guidelines: management of cholestatic liver diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Effectiveness of colesevelam hydrochloride in decreasing LDL cholesterol in patients with primary hypercholesterolemia: a 24-week randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Effect of bile acid sequestrants on glycaemic control: protocol for a systematic review with meta-analysis of randomised controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Lysophosphatidic acid is a potential mediator of cholestatic pruritus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The TGR5 receptor mediates bile acid-induced itch and analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Chenodeoxycholic acid inhibits increased cholesterol and cholestanol synthesis in patients with cerebrotendinous Xanthomatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Effect of Jaundice on Rheumatoid Arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Identification of a nuclear receptor that is activated by farnesol metabolites

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Pregnane X receptor is a target of farnesoid X receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Effects of corticosteroids on bilirubin metabolism in patients with Gilbert's syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151

Ursodeoxycholic acid treatment of gallstones. Dose-response study and possible mechanism of action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2013.151