CCN2: a novel, specific and valid target for anti-fibrotic drug intervention (Q38121157)

29 August 2017

title

CCN2: a novel, specific and valid target for anti-fibrotic drug intervention (English)

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29 August 2017

Andrew Leask

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29 August 2017

language of work or name

English

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publication date

13 July 2013

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Expert Opinion on Therapeutic Targets

29 August 2017

published in

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29 August 2017

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29 August 2017

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29 August 2017

page(s)

1067-1071

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The modular architecture of a new family of growth regulators related to connective tissue growth factor

29 August 2017

cites work

1 reference

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CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling

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CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

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Significant Correlation Between Connective Tissue Growth Factor Gene Expression and Skin Sclerosis in Tissue Sections from Patients with Systemic Sclerosis

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Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor

21 January 2018

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Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan

21 January 2018

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Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis.

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CCN2 expression and localization in melanoma cells

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Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.

21 January 2018

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Connective tissue growth factor promoter activity in normal and wounded skin

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Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts

21 January 2018

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Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts

21 January 2018

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The induction of CCN2 by TGFbeta1 involves Ets-1.

21 January 2018

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CCN2 is required for bleomycin‐induced skin fibrosis in mice

21 January 2018

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Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness

21 January 2018

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The role of endothelin-1 signaling in the fibrosis observed in systemic sclerosis

21 January 2018

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CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts

21 January 2018

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Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

21 January 2018

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Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease

21 January 2018

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CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells

21 January 2018

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CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.

21 January 2018

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Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development

21 January 2018

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Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo

21 January 2018

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The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts

21 January 2018

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CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin

21 January 2018

1 reference

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CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1

21 January 2018

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Promotion of attachment of human bone marrow stromal cells by CCN2.

21 January 2018

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Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis

21 January 2018

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Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs

21 January 2018

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Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

21 January 2018

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Matricellular proteins: priming the tumour microenvironment for cancer development and metastasis

21 January 2018

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Fibroproliferative disorders and their mechanobiology

21 January 2018

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Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA

21 January 2018

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The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor

21 January 2018

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Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells

21 January 2018

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Role of LRP1 in transport of CCN2 protein in chondrocytes.

21 January 2018

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Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome

21 January 2018

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A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1.

21 January 2018

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The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal musc

21 January 2018

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Decorin interacts with connective tissue growth factor (CTGF)/CCN2 by LRR12 inhibiting its biological activity

21 January 2018

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Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

21 January 2018

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Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria

21 January 2018

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10.1517/14728222.2013.812074

21 January 2018

Identifiers

DOI

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29 August 2017

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