Argonaute proteins: functional insights and emerging roles (Q38111603)

29 August 2017

title

Argonaute proteins: functional insights and emerging roles (English)

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29 August 2017

Gunter Meister

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29 August 2017

publication date

4 June 2013

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29 August 2017

published in

Nature Reviews Genetics

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29 August 2017

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29 August 2017

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29 August 2017

page(s)

447-459

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29 August 2017

cites work

RNAi in budding yeast

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Slicer and the argonautes

31 March 2020

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Argonaute proteins: mediators of RNA silencing

31 March 2020

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Argonaute proteins: key players in RNA silencing

31 March 2020

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PIWI-interacting small RNAs: the vanguard of genome defence

31 March 2020

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Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi

31 March 2020

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Multiple roles for small RNAs during plant reproduction.

31 March 2020

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A three-dimensional view of the molecular machinery of RNA interference

31 March 2020

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Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein

31 March 2020

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The N domain of Argonaute drives duplex unwinding during RISC assembly

31 March 2020

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Structure of yeast Argonaute with guide RNA

31 March 2020

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Argonaute2 is the catalytic engine of mammalian RNAi

31 March 2020

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

31 March 2020

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Turning catalytically inactive human Argonaute proteins into active slicer enzymes

31 March 2020

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The Structure of Human Argonaute-2 in Complex with miR-20a

31 March 2020

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The Crystal Structure of Human Argonaute2

31 March 2020

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Functional siRNAs and miRNAs Exhibit Strand Bias

31 March 2020

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Asymmetry in the assembly of the RNAi enzyme complex

31 March 2020

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Identification of novel argonaute-associated proteins

31 March 2020

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A human, ATP-independent, RISC assembly machine fueled by pre-miRNA

31 March 2020

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Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

31 March 2020

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Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein

31 March 2020

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R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

31 March 2020

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A protein sensor for siRNA asymmetry

31 March 2020

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

31 March 2020

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TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

31 March 2020

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The role of PACT in the RNA silencing pathway

31 March 2020

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siRNA repositioning for guide strand selection by human Dicer complexes

31 March 2020

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HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells

31 March 2020

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In vitro assembly of plant RNA-induced silencing complexes facilitated by molecular chaperone HSP90.

31 March 2020

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Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes

31 March 2020

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Dicer-dependent and -independent Argonaute2 protein interaction networks in mammalian cells

31 March 2020

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Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins

31 March 2020

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RNA helicase A interacts with RISC in human cells and functions in RISC loading

31 March 2020

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Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

31 March 2020

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RISC assembly defects in the Drosophila RNAi mutant armitage.

31 March 2020

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Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects

31 March 2020

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Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

31 March 2020

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

31 March 2020

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Cleavage of the siRNA passenger strand during RISC assembly in human cells

31 March 2020

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Structure of C3PO and mechanism of human RISC activation

31 March 2020

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C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation

31 March 2020

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Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila

31 March 2020

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Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

31 March 2020

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MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs

31 March 2020

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The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila

31 March 2020

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shutdown is a component of the Drosophila piRNA biogenesis machinery.

31 March 2020

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A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing

31 March 2020

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Hierarchical rules for Argonaute loading in Drosophila

31 March 2020

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Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.

31 March 2020

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Sorting of Drosophila small silencing RNAs

31 March 2020

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Distinct mechanisms for microRNA strand selection by Drosophila Argonautes

31 March 2020

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Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins

31 March 2020

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Small RNA sorting: matchmaking for Argonautes.

31 March 2020

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Origin, biogenesis, and activity of plant microRNAs

31 March 2020

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AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana

31 March 2020

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Cytoplasmic Arabidopsis AGO7 accumulates in membrane-associated siRNA bodies and is required for ta-siRNA biogenesis

31 March 2020

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Specificity of ARGONAUTE7-miR390 interaction and dual functionality in TAS3 trans-acting siRNA formation

31 March 2020

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Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide

31 March 2020

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Control of female gamete formation by a small RNA pathway in Arabidopsis

31 March 2020

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Arabidopsis Argonaute10 specifically sequesters miR166/165 to regulate shoot apical meristem development

31 March 2020

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Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin.

31 March 2020

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microRNAs associated with the different human Argonaute proteins

31 March 2020

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Quantitative functions of Argonaute proteins in mammalian development.

31 March 2020

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AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline

31 March 2020

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DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation

31 March 2020

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A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

31 March 2020

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Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2

31 March 2020

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ArabidopsisArgonaute MID domains use their nucleotide specificity loop to sort small RNAs

31 March 2020

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MicroRNAs: target recognition and regulatory functions

31 March 2020

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

31 March 2020

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The widespread regulation of microRNA biogenesis, function and decay

31 March 2020

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Mechanisms of gene silencing by double-stranded RNA

31 March 2020

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Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish

31 March 2020

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Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

31 March 2020

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miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay

31 March 2020

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Mammalian microRNAs predominantly act to decrease target mRNA levels

31 March 2020

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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

31 March 2020

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Disruption of GW bodies impairs mammalian RNA interference

31 March 2020

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The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans

31 March 2020

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Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

31 March 2020

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The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release

31 March 2020

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PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

31 March 2020

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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

31 March 2020

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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

31 March 2020

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GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

31 March 2020

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The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

31 March 2020

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Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells

31 March 2020

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Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs

31 March 2020

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Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

31 March 2020

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MicroRNA regulation by RNA-binding proteins and its implications for cancer

31 March 2020

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Pumilio facilitates miRNA regulation of the E2F3 oncogene

31 March 2020

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Human UPF1 participates in small RNA-induced mRNA downregulation

31 March 2020

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LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing

31 March 2020

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Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing

31 March 2020

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The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

31 March 2020

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Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.

31 March 2020

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A conserved PUF-Ago-eEF1A complex attenuates translation elongation.

31 March 2020

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microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein

31 March 2020

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Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability

31 March 2020

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SMN-mediated assembly of RNPs: a complex story

31 March 2020

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How does the royal family of Tudor rule the PIWI-interacting RNA pathway?

31 March 2020

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Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

31 March 2020

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Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila

31 March 2020

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Prolyl 4-hydroxylation regulates Argonaute 2 stability

31 March 2020

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Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.

31 March 2020

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The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

31 March 2020

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The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function

31 March 2020

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nhl-2 Modulates microRNA activity in Caenorhabditis elegans

31 March 2020

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The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

31 March 2020

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Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

31 March 2020

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miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

31 March 2020

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A microRNA in a multiple-turnover RNAi enzyme complex

31 March 2020

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Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

31 March 2020

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Phosphorylation of human Argonaute proteins affects small RNA binding.

31 March 2020

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Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells

31 March 2020

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A multifunctional human Argonaute2-specific monoclonal antibody

31 March 2020

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Specific and potent RNAi in the nucleus of human cells

31 March 2020

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Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

31 March 2020

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Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

31 March 2020

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RNAi-mediated targeting of heterochromatin by the RITS complex

31 March 2020

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RNAi-dependent formation of heterochromatin and its diverse functions

31 March 2020

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Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation

31 March 2020

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ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation

31 March 2020

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Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats.

31 March 2020

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An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana.

31 March 2020

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The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center

31 March 2020

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RNA-mediated chromatin-based silencing in plants

31 March 2020

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RNAi protects the Caenorhabditis elegans germline against transposition

31 March 2020

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A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans

31 March 2020

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Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi

31 March 2020

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An Argonaute transports siRNAs from the cytoplasm to the nucleus.

31 March 2020

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Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription.

31 March 2020

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A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

31 March 2020

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31 March 2020

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Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery

31 March 2020

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RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function

31 March 2020

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Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

31 March 2020

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Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

31 March 2020

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Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

31 March 2020

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Antisense transcripts are targets for activating small RNAs

31 March 2020

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Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

31 March 2020

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Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

31 March 2020

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Control of alternative splicing through siRNA-mediated transcriptional gene silencing.

31 March 2020

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Argonaute proteins couple chromatin silencing to alternative splicing.

31 March 2020

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Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression.

31 March 2020

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The spliceosome: design principles of a dynamic RNP machine

31 March 2020

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A role for small RNAs in DNA double-strand break repair.

31 March 2020

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A small RNA response at DNA ends in Drosophila

31 March 2020

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Site-specific DICER and DROSHA RNA products control the DNA-damage response

31 March 2020

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Active turnover modulates mature microRNA activity in Caenorhabditis elegans

31 March 2020

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A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

31 March 2020

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Mirtrons: microRNA biogenesis via splicing

31 March 2020

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A human snoRNA with microRNA-like functions

31 March 2020

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A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity

31 March 2020

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Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

31 March 2020

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Precursor microRNA-programmed silencing complex assembly pathways in mammals

31 March 2020

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The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans

31 March 2020

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An endogenous small interfering RNA pathway in Drosophila

31 March 2020

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Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

31 March 2020

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The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

31 March 2020

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Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

31 March 2020

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Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

31 March 2020

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A distinct small RNA pathway silences selfish genetic elements in the germline

31 March 2020

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Structure and function of Zucchini endoribonuclease in piRNA biogenesis

31 March 2020

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Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc

31 March 2020

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The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

31 March 2020

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Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains

31 March 2020

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CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors

31 March 2020

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piRNAs--the ancient hunters of genome invaders

31 March 2020

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Small RNAs as guardians of the genome

31 March 2020

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A role for the P-body component GW182 in microRNA function

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23732335

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3462

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Dimensions Publication ID

29 August 2017

1041016180

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