Arrestins come of age: a personal historical perspective (Q38114209)

29 August 2017

title

Arrestins come of age: a personal historical perspective (English)

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29 August 2017

Robert J Lefkowitz

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29 August 2017

publication date

1 January 2013

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Progress in Molecular Biology and Translational Science

29 August 2017

published in

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29 August 2017

volume

118

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29 August 2017

page(s)

3-18

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beta-Arrestin: a protein that regulates beta-adrenergic receptor function

29 August 2017

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β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix

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11 October 2022

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Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin

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11 October 2022

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Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

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11 October 2022

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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

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11 October 2022

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Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

A 48 kDa protein arrests cGMP phosphodiesterase activation in retinal rod disk membranes

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

G protein-coupled receptor kinases

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestin-mediated localization of smoothened to the primary cilium

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestins and cell signaling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

On the origins of arrestin and rhodopsin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Functional specialization of beta-arrestin interactions revealed by proteomic analysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

A family of receptors coupled to guanine nucleotide regulatory proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

The arrestin fold: variations on a theme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Primary and secondary structure of bovine retinal S antigen (48-kDa protein).

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Morphine side effects in beta-arrestin 2 knockout mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

The structure of bovine rhodopsin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Cyclic GMP cascade of vision

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Teaching old receptors new tricks: biasing seven-transmembrane receptors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Light-regulated binding of rhodopsin kinase and other proteins to cattle photoreceptor membranes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Functional selectivity through protean and biased agonism: who steers the ship?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Therapeutic potential of β-arrestin- and G protein-biased agonists.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Enhanced morphine analgesia in mice lacking beta-arrestin 2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Rhodopsin and bacteriorhodopsin: structure-function relationships

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/B978-0-12-394440-5.00001-2

Identifiers

DOI

10.1016/B978-0-12-394440-5.00001-2

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29 August 2017

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