FLIP: molecular switch between apoptosis and necroptosis (Q38102627)

28 August 2017

title

FLIP: molecular switch between apoptosis and necroptosis (English)

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28 August 2017

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JingJing Gong

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28 August 2017

Saikartik A Kumar

series ordinal

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28 August 2017

Gilian Graham

series ordinal

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28 August 2017

Addanki P Kumar

series ordinal

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28 August 2017

publication date

26 April 2013

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28 August 2017

published in

Molecular Carcinogenesis

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

675-685

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Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths

28 August 2017

cites work

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Programmed cell death and cancer

21 January 2018

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Apoptosis in the pathogenesis and treatment of disease

21 January 2018

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Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia

21 January 2018

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

21 January 2018

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The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

21 January 2018

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

21 January 2018

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

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Mitochondria and apoptosis

21 January 2018

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Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

21 January 2018

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An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

21 January 2018

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

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Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

21 January 2018

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New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy

21 January 2018

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Autophagy and disease: always two sides to a problem

21 January 2018

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FLIP-mediated autophagy regulation in cell death control

21 January 2018

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Antioxidant c-FLIP inhibits Fas ligand-induced NF-kB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner

21 January 2018

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

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Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

21 January 2018

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NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.

21 January 2018

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Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

21 January 2018

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Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

21 January 2018

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Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

21 January 2018

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Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland

21 January 2018

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Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model

21 January 2018

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Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence

21 January 2018

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Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis

21 January 2018

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Nitric oxide negatively regulates Fas CD95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of FLICE inhibitory protein

21 January 2018

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E1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S.

21 January 2018

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Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis.

21 January 2018

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Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

21 January 2018

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

21 January 2018

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Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival

21 January 2018

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ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis

21 January 2018

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KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels

21 January 2018

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Mind bomb 1 regulation of cFLIP interactions

21 January 2018

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Effect of transgenic overexpression of FLIP on lymphocytes on development and resolution of experimental autoimmune thyroiditis

21 January 2018

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Comparison of sensitivity of Th1, Th2, and Th17 cells to Fas-mediated apoptosis

21 January 2018

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Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-FLIP(L).

21 January 2018

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FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis

21 January 2018

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c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging

21 January 2018

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Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain

21 January 2018

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SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells.

21 January 2018

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α‐TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway

21 January 2018

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Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents

21 January 2018

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Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP

21 January 2018

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Programmed cell death 4 (PDCD4) mediates the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by down-regulation of FLIP expression

21 January 2018

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The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells

21 January 2018

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Death receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells.

21 January 2018

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Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent

21 January 2018

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Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells

21 January 2018

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Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis

21 January 2018

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Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein

21 January 2018

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c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

21 January 2018

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Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation

21 January 2018

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The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.

21 January 2018

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Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

21 January 2018

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4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

21 January 2018

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Nonsteroidal anti-inflammatory drugs induce apoptosis in cutaneous T-cell lymphoma cells and enhance their sensitivity for TNF-related apoptosis-inducing ligand

21 January 2018

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Knockdown of c-FLIP(L) enhanced AD5-10 anti-death receptor 5 monoclonal antibody-induced apoptosis in human lung cancer cells

21 January 2018

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The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.

21 January 2018

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Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2.

21 January 2018

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Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis

21 January 2018

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The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients.

21 January 2018

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Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells

21 January 2018

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Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells

21 January 2018

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Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

21 January 2018

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Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells

21 January 2018

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Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin.

21 January 2018

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RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery

21 January 2018

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Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL.

21 January 2018

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Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway

21 January 2018

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Stromal Anti-Apoptotic Androgen Receptor Target Gene c-FLIP in Prostate Cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MC.22027

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28 August 2017

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