Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro (Q38106149)

28 August 2017

title

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro (English)

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28 August 2017

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Tessa Moses

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Jacob Pollier

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Alain Goossens

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Johan M Thevelein

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language of work or name

English

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publication date

14 May 2013

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28 August 2017

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28 August 2017

volume

200

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28 August 2017

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28 August 2017

page(s)

27-43

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Combined effects of elevated CO2 and herbivore damage on alfalfa and cotton.

28 August 2017

cites work

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Herbivore-induced responses in alfalfa (Medicago sativa).

21 January 2018

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Global transcription machinery engineering: a new approach for improving cellular phenotype

21 January 2018

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Directed evolution of biocatalysts

21 January 2018

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Recent advances in artemisinin production through heterologous expression

21 January 2018

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Molecular activities, biosynthesis and evolution of triterpenoid saponins

21 January 2018

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Toward a science of metabolic engineering

21 January 2018

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Establishment of new crops for the production of natural rubber

21 January 2018

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21 January 2018

Terpenoid biomaterials

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Engineering the essence of plants

21 January 2018

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Parts plus pipes: synthetic biology approaches to metabolic engineering

21 January 2018

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Cell-free protein synthesis: applications come of age.

21 January 2018

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An automated flow for directed evolution based on detection of promiscuous scaffolds using spatial and electrostatic properties of catalytic residues

21 January 2018

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Active site detection by spatial conformity and electrostatic analysis--unravelling a proteolytic function in shrimp alkaline phosphatase

21 January 2018

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Production of isoprenoid pharmaceuticals by engineered microbes

21 January 2018

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Synthetic biology through biomolecular design and engineering.

21 January 2018

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Metabolic engineering for plant natural product biosynthesis in microbes

21 January 2018

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The family of terpene synthases in plants: a mid‐size family of genes for specialized metabolism that is highly diversified throughout the kingdom

21 January 2018

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Biological activities and potential molecular targets of cucurbitacins: a focus on cancer

21 January 2018

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Strategy and success for the directed evolution of enzymes

21 January 2018

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Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.

21 January 2018

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Transcriptional machineries in jasmonate-elicited plant secondary metabolism.

21 January 2018

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Attracting friends to feast on foes: engineering terpene emission to make crop plants more attractive to herbivore enemies

21 January 2018

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Cytochromes P450 in nanodiscs.

21 January 2018

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Naturally Occurring Triterpenoid Saponins

21 January 2018

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The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis

21 January 2018

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Biosynthesis, function and metabolic engineering of plant volatile organic compounds.

21 January 2018

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Synthetic protein scaffolds provide modular control over metabolic flux.

21 January 2018

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Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

21 January 2018

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DNA assembly for synthetic biology: from parts to pathways and beyond.

21 January 2018

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Generation of the potent anti-malarial drug artemisinin in tobacco

21 January 2018

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Nutritious crops producing multiple carotenoids--a metabolic balancing act.

21 January 2018

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Polycistronic viral vectors

21 January 2018

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Metabolic diversification--independent assembly of operon-like gene clusters in different plants.

21 January 2018

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ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism

21 January 2018

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Synthetic biology projects in vitro

21 January 2018

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Biosynthesis and metabolism of brassinosteroids

21 January 2018

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CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis

21 January 2018

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Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

21 January 2018

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Genetically transformed roots: from plant disease to biotechnological resource.

21 January 2018

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Bioprocessing of plant cell cultures for mass production of targeted compounds.

21 January 2018

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The function of terpene natural products in the natural world

21 January 2018

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Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome

21 January 2018

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Directed enzyme evolution: beyond the low-hanging fruit

21 January 2018

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Improved cloning and expression of cytochrome P450s and cytochrome P450 reductase in yeast

21 January 2018

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Synthetic promoter libraries--tuning of gene expression

21 January 2018

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Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng

21 January 2018

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The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng

21 January 2018

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A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots

21 January 2018

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Cell-free biology: exploiting the interface between synthetic biology and synthetic chemistry

21 January 2018

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Cell-free synthetic biology: thinking outside the cell

21 January 2018

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A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas

21 January 2018

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Engineering enzymatic cascades on nanoscale scaffolds

21 January 2018

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Combinatorial biosynthesis of medicinal plant secondary metabolites

21 January 2018

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Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli

21 January 2018

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Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.

21 January 2018

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Synthetic biology for synthetic chemistry

21 January 2018

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Manufacturing molecules through metabolic engineering

21 January 2018

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Synthetic biology and the development of tools for metabolic engineering

21 January 2018

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Engineering triterpene production in Saccharomyces cerevisiae-beta-amyrin synthase from Artemisia annua

21 January 2018

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Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering

21 January 2018

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21 January 2018

Metabolic Engineering

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Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

21 January 2018

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Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts

21 January 2018

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Expanding nature's small molecule diversity via in vitro biosynthetic pathway engineering

21 January 2018

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Modulation of Triterpene Saponin Production: In Vitro Cultures, Elicitation, and Metabolic Engineering

21 January 2018

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Terpenoid biosynthesis in trichomes--current status and future opportunities

21 January 2018

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Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A.

21 January 2018

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Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin

21 January 2018

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Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

21 January 2018

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Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

21 January 2018

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

21 January 2018

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Plant production systems for bioactive small molecules

21 January 2018

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Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers.

21 January 2018

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Primary genotypic resistance of HIV-1 to the maturation inhibitor PA-457 in protease inhibitor-experienced patients.

21 January 2018

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Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2.

21 January 2018

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Steroidal lactones from Withania somnifera, an ancient plant for novel medicine

21 January 2018

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Pathway engineering for functional isoprenoids

21 January 2018

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Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action

21 January 2018

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Plant volatile terpenoid metabolism: biosynthetic genes, transcriptional regulation and subcellular compartmentation.

21 January 2018

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Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis.

21 January 2018

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Biosynthesis of cholesterol and other sterols

21 January 2018

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Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae

21 January 2018

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A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism

21 January 2018

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Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase

21 January 2018

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Synthesis of combinatorial libraries based on terpenoid scaffolds

21 January 2018

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The JAZ proteins: a crucial interface in the jasmonate signaling cascade

21 January 2018

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Jasmonate-inducible gene: What does it mean?

21 January 2018

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Bardoxolone methyl and kidney function in CKD with type 2 diabetes

21 January 2018

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Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

21 January 2018

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Biosynthetic diversity in plant triterpene cyclization

21 January 2018

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Diversity of P450 enzymes in the biosynthesis of natural products

21 January 2018

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21 January 2018

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Combinatorial biosynthesis in plants: a (p)review on its potential and future exploitation

21 January 2018

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Emergent properties of reduced-genome Escherichia coli.

21 January 2018

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A different function for a member of an ancient and highly conserved cytochrome P450 family: from essential sterols to plant defense.

21 January 2018

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Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds.

21 January 2018

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

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Production and engineering of terpenoids in plant cell culture

21 January 2018

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Novel proteins in emulsions using in vitro compartmentalization.

21 January 2018

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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

21 January 2018

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Integrating carbon-halogen bond formation into medicinal plant metabolism.

21 January 2018

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Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

21 January 2018

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Combinatorial biosynthesis of carotenoids in a heterologous host: a powerful approach for the biosynthesis of novel structures.

21 January 2018

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Triterpenoid biosynthesis and engineering in plants

21 January 2018

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Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin

21 January 2018

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DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

21 January 2018

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The cytochrome P450 engineering database: Integration of biochemical properties

21 January 2018

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Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection

21 January 2018

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New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

21 January 2018

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Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis

21 January 2018

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Advances in saponin-based adjuvants

21 January 2018

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Methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula.

21 January 2018

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Terpene synthases and the regulation, diversity and biological roles of terpene metabolism

21 January 2018

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The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer

21 January 2018

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Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia

21 January 2018

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A C35 carotenoid biosynthetic pathway

21 January 2018

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Evolution of a pathway to novel long-chain carotenoids

21 January 2018

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Diversifying carotenoid biosynthetic pathways by directed evolution

21 January 2018

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An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4+ T Cell Responses in Seronegative Volunteers

21 January 2018

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High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates

21 January 2018

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Structure and dynamics of the isoprenoid pathway network

21 January 2018

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Available methods for assembling expression cassettes for synthetic biology.

21 January 2018

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Privileged scaffolds for library design and drug discovery

21 January 2018

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Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules

21 January 2018

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Engineering triterpene metabolism in tobacco

21 January 2018

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Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants

21 January 2018

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Conjugates of betulin derivatives with AZT as potent anti-HIV agents

21 January 2018

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Divergent evolution of oxidosqualene cyclases in plants.

21 January 2018

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Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways

21 January 2018

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Designed divergent evolution of enzyme function

21 January 2018

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Chromosomal promoter replacement of the isoprenoid pathway for enhancing carotenoid production in E. coli

21 January 2018

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Methods and options for the heterologous production of complex natural products.

21 January 2018

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Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A

21 January 2018

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Elicitor signal transduction leading to production of plant secondary metabolites.

21 January 2018

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Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles

21 January 2018

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Platforms and networks in triterpenoid pharmacology

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/NPH.12325

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28 August 2017

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