Amyloid β, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track? (Q38099671)

23593992

28 August 2017

title

Amyloid β, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track? (English)

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28 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

Zaira Esposito

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

Lorena Belli

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

Sofia Toniolo

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

Giuseppe Sancesario

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

Claudio Bianconi

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

publication date

18 April 2013

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23593992

CNS Neuroscience & Therapeutics

28 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

volume

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14 May 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

page(s)

549-555

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

14 May 2020

cites work

1 reference

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

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Amyloid beta-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in vivo.

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Alzheimer's disease amyloid beta-protein and synaptic function

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Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

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Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease

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Glutamatergic systems in Alzheimer's disease.

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Resolving controversies on the path to Alzheimer's therapeutics

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Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

21 January 2018

1 reference

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections

21 January 2018

1 reference

Amyloid β peptide oligomers directly activate NMDA receptors.

21 January 2018

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Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits

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Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

21 January 2018

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Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

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Alzheimer's disease: synapses gone cold

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Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse

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Cortical plasticity in Alzheimer's disease in humans and rodents.

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Senescent synapses and hippocampal circuit dynamics

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Cholinergic function and Alzheimer's disease

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Defining molecular targets to prevent Alzheimer disease

21 January 2018

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Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.

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Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors

21 January 2018

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Hippocampal synaptic transmission enhanced by low concentrations of nicotine.

21 January 2018

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Nicotinic receptors, amyloid-beta, and synaptic failure in Alzheimer's disease

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A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides

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Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

21 January 2018

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Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats

21 January 2018

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Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures

21 January 2018

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

21 January 2018

1 reference

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

21 January 2018

1 reference

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine

21 January 2018

1 reference

Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation

21 January 2018

1 reference

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

21 January 2018

1 reference

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

In vitro galantamine-memantine co-application: mechanism of beneficial action

21 January 2018

1 reference

Rationale for combination therapy with galantamine and memantine in Alzheimer's disease

21 January 2018

1 reference

Memantine and cholinesterase inhibitor combination therapy for Alzheimer's disease: a systematic review

21 January 2018

1 reference

Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils

21 January 2018

1 reference

Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease

21 January 2018

1 reference

Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

21 January 2018

1 reference

Memantine in moderate-to-severe Alzheimer's disease

21 January 2018

1 reference

Long-term course and effectiveness of combination therapy in Alzheimer disease

21 January 2018

1 reference

Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial

21 January 2018

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Lack of pharmacokinetic or pharmacodynamic interaction between memantine and donepezil

21 January 2018

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Donepezil and memantine for moderate-to-severe Alzheimer's disease.

21 January 2018

1 reference

ACP Journal Club. Donepezil or memantine improved cognitive functioning in moderate-to-severe Alzheimer disease.

21 January 2018

1 reference

Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial.

21 January 2018

1 reference

Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment.

21 January 2018

1 reference

CSF biomarkers predict a more malignant outcome in Alzheimer disease.

21 January 2018

1 reference

CSF biomarkers in relationship to cognitive profiles in Alzheimer disease

21 January 2018

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CSF markers for incipient Alzheimer's disease

21 January 2018

1 reference

Enrichment of MCI and early Alzheimer's disease treatment trials using neurochemical and imaging candidate biomarkers.

21 January 2018

1 reference

Cerebrospinal fluid β-amyloid 1-42 correlates with rate of progression in Alzheimer's disease

21 January 2018

1 reference

Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo

21 January 2018

1 reference

Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden

21 January 2018

1 reference

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease

21 January 2018

1 reference

Genetic enhancement of learning and memory in mice

21 January 2018

1 reference

21 January 2018

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21 January 2018

1 reference

The effects of aging on N-methyl-D-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory.

21 January 2018

1 reference

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

21 January 2018

1 reference

Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice

21 January 2018

1 reference

12 December 2020

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

12 December 2020

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

12 December 2020

Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease

1 reference

12 December 2020

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

1 reference

12 December 2020

Memantine for dementia

1 reference

12 December 2020

Memantine treatment in patients with mild to moderate Alzheimer's disease: results of a randomised, double-blind, placebo-controlled 6-month study.

1 reference

12 December 2020

Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?

1 reference

12 December 2020

Impaired LTP- but not LTD-like cortical plasticity in Alzheimer's disease patients

1 reference

12 December 2020

Selective impairment of some forms of synaptic plasticity by oligomeric amyloid-β peptide in the mouse hippocampus: implication of extrasynaptic NMDA receptors

1 reference

12 December 2020

Modulation of α7 nicotinic acetylcholine receptor and fibrillar amyloid-β interactions in Alzheimer's disease brain

1 reference

12 December 2020

Neurodegeneration mediated by glutamate and beta-amyloid peptide: a comparison and possible interaction

1 reference

12 December 2020

CSF excitatory amino acids and severity of illness in Alzheimer's disease

1 reference

12 December 2020

Identifiers

DOI

10.1111/CNS.12095

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json

14 May 2020

23593992

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493397&resulttype=core&format=json