The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system (Q38095672)

28 August 2017

title

The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system (English)

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28 August 2017

Adelbert Bacher

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28 August 2017

Markus Fischer

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28 August 2017

Rudolf Ladenstein

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28 August 2017

language of work or name

English

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publication date

24 April 2013

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28 August 2017

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28 August 2017

volume

280

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28 August 2017

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28 August 2017

page(s)

2537-2563

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Flavoenzymes that catalyse reactions with no net redox change

28 August 2017

cites work

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Domain structure of riboflavin synthase

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Directed evolution of a protein container

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Tunnel plasticity and quaternary structural integrity of a pentameric protein ring

21 January 2018

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X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons

21 January 2018

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Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase fromBacillus anthracis

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The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue

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High order quaternary arrangement confers increased structural stability to Brucella sp. lumazine synthase

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Divergence in macromolecular assembly: X-ray crystallographic structure analysis of lumazine synthase from Brucella abortus

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Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors

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21 January 2018

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Sequence determinants of quaternary structure in lumazine synthase

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales

21 January 2018

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Crystallographic studies on decameric Brucella spp. Lumazine synthase: a novel quaternary arrangement evolved for a new function?

21 January 2018

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Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase

21 January 2018

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Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.

21 January 2018

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Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

21 January 2018

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Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes

21 January 2018

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Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase

21 January 2018

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Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase

21 January 2018

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Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

21 January 2018

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Design, synthesis, and evaluation of 9-D-ribityl-1,3,7-trihydro-2,6,8-purinetrione, a potent inhibitor of riboflavin synthase and lumazine synthase

21 January 2018

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Discovery and development of a small molecule library with lumazine synthase inhibitory activity

21 January 2018

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A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors

21 January 2018

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Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase

21 January 2018

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Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis

21 January 2018

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Crystal Structures of the Lumazine Protein from Photobacterium kishitanii in Complexes with the Authentic Chromophore, 6,7-Dimethyl- 8-(1'-D-Ribityl) Lumazine, and Its Analogues, Riboflavin and Flavin Mononucleotide, at High Resolution

21 January 2018

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Structure of lumazine protein, an optical transponder of luminescent bacteria

21 January 2018

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Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain

21 January 2018

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Current developments and challenges in the search for a naturally selected Diels-Alderase

21 January 2018

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Electrostatic effects in a large enzyme complex: subunit interactions and electrostatic potential field of the icosahedral beta 60 capsid of heavy riboflavin synthase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/FEBS.12255

1 reference

28 August 2017

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