Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis (Q38089805)

28 August 2017

title

Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis (English)

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28 August 2017

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Ute Galm

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28 August 2017

Ben Shen

series ordinal

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28 August 2017

language of work or name

English

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publication date

1 October 2006

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

409-437

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Natural products as sources of new drugs over the period 1981-2002.

28 August 2017

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Genetic approaches to harvesting lichen products

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Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus

21 January 2018

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Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein

21 January 2018

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Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

21 January 2018

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Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

21 January 2018

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Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters

21 January 2018

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Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

21 January 2018

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Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide

21 January 2018

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Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736.

21 January 2018

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Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.

21 January 2018

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The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

21 January 2018

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Molecular characterization of the safracin biosynthetic pathway from Pseudomonas fluorescens A2-2: designing new cytotoxic compounds

21 January 2018

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Cloning and heterologous expression of the epothilone gene cluster.

21 January 2018

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A multiplasmid approach to preparing large libraries of polyketides

21 January 2018

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Engineered biosynthesis of a complete macrolactone in a heterologous host

21 January 2018

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Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans

21 January 2018

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Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host

21 January 2018

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Heterologous production of epothilone C and D in Escherichia coli.

21 January 2018

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Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning, sequencing, and functional analysis of an iterative type I polyketide synthase gene cluster for biosynthesis of the antitumor chlorinated polyenone neocarzilin in "Streptomyces carzinostaticus"

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Optimizing the heterologous production of epothilone D in Myxococcus xanthus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The biosynthesis of indolocarbazoles in a heterologous E. coli host.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Compilation and analysis of DNA sequences associated with apparent streptomycete promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Combinatorial biosynthesis of antibiotics: challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Combinatorial biosynthesis of antitumor indolocarbazole compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

StreptomycesGenetics: A Genomic Perspective

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Substrate recognition by nonribosomal peptide synthetase multi-enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Polyketide and nonribosomal peptide antibiotics: modularity and versatility

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Engineered biosynthesis of the peptide antibiotic bacitracin in the surrogate host Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biotechnological prospects from metagenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of uncultivated prokaryotes: isolation and analysis of a 40-kilobase-pair genome fragment from a planktonic marine archaeon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Artificial chromosomes for antibiotic-producing actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Assembly of large genomic segments in artificial chromosomes by homologous recombination in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Artificial chromosome libraries of Streptomyces coelicolor A3(2) and Planobispora rosea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The commercial production of chemicals using pathway engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthetic Studies of Daunorubicin and Tetracenomycin C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of a vanillic acid non-oxidative decarboxylation gene cluster from Streptomyces sp. D7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum. Its gene structure relative to that of other polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety and assembly of the peptidyl nucleoside antibiotic nikkomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.1.5.409

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.55.1063

Cloning and Heterologous Expression of Blasticidin S Biosynthetic Genes from Streptomyces griseochromogenes.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.51.570

Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.171.2.887-895.1989

Identifiers

DOI

10.1517/17460441.1.5.409

1 reference

28 August 2017

1 reference