Exploring the multifactorial nature of autism through computational systems biology: calcium and the Rho GTPase RAC1 under the spotlight (Q38086129)

28 August 2017

title

Exploring the multifactorial nature of autism through computational systems biology: calcium and the Rho GTPase RAC1 under the spotlight (English)

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28 August 2017

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Fares Zeidán-Chuliá

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28 August 2017

José Luiz Rybarczyk-Filho

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28 August 2017

Alla B Salmina

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28 August 2017

Ben-Hur Neves de Oliveira

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28 August 2017

Mami Noda

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28 August 2017

José Cláudio F Moreira

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28 August 2017

language of work or name

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2 March 2013

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28 August 2017

published in

NeuroMolecular Medicine

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

364-383

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Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The neurobiology of social cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Sulphation deficit in "low-functioning" autistic children: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

21 January 2018

Neuroanatomy of autism

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The hyperserotonemia of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Effects of disrupting the cholinergic system on short-term spatial memory in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neurotensin is increased in serum of young children with autistic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neurotensin receptor mechanisms and its modulation of glutamate transmission in the brain: relevance for neurodegenerative diseases and their treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Integration of signalling pathways regulated by small GTPases and calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The amygdala theory of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Social intelligence in the normal and autistic brain: an fMRI study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Differentiating autism and Asperger syndrome on the basis of language delay or impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Autism and Clostridium tetani

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Look who is weaving the neural web: glial control of synapse formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Association between a GABRB3 polymorphism and autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The Neuropathology of Autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Minicolumnar pathology in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Radial cytoarchitecture and patterns of cortical connectivity in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Minicolumnar abnormalities in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

ViaComplex: software for landscape analysis of gene expression networks in genomic context.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

How to identify essential genes from molecular networks?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Differential monocyte responses to TLR ligands in children with autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Calcium and oxidative stress: from cell signaling to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

GABA(A) receptor downregulation in brains of subjects with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Astrocytes coordinate synaptic networks: balanced excitation and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Therapy and epidemiology of autism--clostridial spores as key elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Gastrointestinal microflora studies in late-onset autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

21 January 2018

The prevalence of autism

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Tranylcypromine: new perspectives on an "old" drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Bioconductor: open software development for computational biology and bioinformatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Targeting neurotensin as a potential novel approach for the treatment of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Brain transcriptional and epigenetic associations with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Social behavior in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Normal levels of Rac1 are important for dendritic but not axonal development in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The tripartite synapse: roles for gliotransmission in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Rho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

GLIA: listening and talking to the synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Evidence for systems-level molecular mechanisms of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Medusa: a simple tool for interaction graph analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Trk receptors: roles in neuronal signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neuropathology of infantile autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Purkinje cell vulnerability and autism: a possible etiological connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neurochemical correlates of autistic disorder: a review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Behavioral and emotional problems in young people with pervasive developmental disorders: relative prevalence, effects of subject characteristics, and empirical classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Nicotinic receptor abnormalities in the cerebellar cortex in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The small GTPase Rac is involved in clustering of hippocampal neurons and fasciculation of their neurites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Physiology of the neurotrophins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

SigFlux: a novel network feature to evaluate the importance of proteins in signal transduction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Genetics of childhood disorders: XLII. Autism, part 1: Diagnosis and assessment in autistic spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Serotonin and dopamine transporter binding in children with autism determined by SPECT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Molecular analysis of nicotinic receptor expression in autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neurogenesis in the amygdala: a new etiologic hypothesis of autism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Genetic variant of glutathione peroxidase 1 in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Serum neurotrophin concentrations in autism and mental retardation: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Intronic Polymorphisms Affecting Alternative Splicing of Human Dopamine D2 Receptor Are Associated with Cocaine Abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

21 January 2018

The genetics of autism

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neonatal separation stress reduces glial fibrillary acidic protein- and S100beta-immunoreactive astrocytes in the rat medial precentral cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

A population genetic approach to mapping neurological disorder genes using deep resequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Effects of nicotinic stimulation on cognitive performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The neurobiology of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Immunity, neuroglia and neuroinflammation in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Astrocytic purinergic signaling coordinates synaptic networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Autism in Brazil: perspectives from science and society

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

False discovery rate, sensitivity and sample size for microarray studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Glial calcium signaling and neuron-glia communication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

A systems pharmacology analysis of major chemotherapy combination regimens used in gastric cancer treatment: predicting potential new protein targets and drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

New players in TLR-mediated innate immunity: PI3K and small Rho GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Towards a genome-wide transcriptogram: the Saccharomyces cerevisiae case.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Short-term benefit from oral vancomycin treatment of regressive-onset autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Analyzing biological network parameters with CentiScaPe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Stereological analysis of amygdala neuron number in autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Increased serum levels of glutamate in adult patients with autism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Cytoscape 2.8: new features for data integration and network visualization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Real-time PCR quantitation of clostridia in feces of autistic children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The amygdala and related structures in the pathophysiology of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Language Disorders: Autism and Other Pervasive Developmental Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Identifying neurocognitive phenotypes in autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Childhood Disintegrative Disorder: Results of the DSM-IV Autism Field Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Potential teratogenic effects of ultrasound on corticogenesis: implications for autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

A dental look at the autistic patient through orofacial pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Bioinformatical and in vitro approaches to essential oil-induced matrix metalloproteinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Centers of complex networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Role of L- and N-type calcium channels in the pathophysiology of traumatic spinal cord white matter injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8224-3

Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation

21 January 2018

1 reference

12 December 2020

Virtual identification of essential proteins within the protein interaction network of yeast

1 reference

12 December 2020

STITCH: interaction networks of chemicals and proteins

1 reference

12 December 2020

1 reference

12 December 2020

Autism and developmental abnormalities in children with perinatal cocaine exposure

1 reference

12 December 2020

Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices.

1 reference

12 December 2020

Analysis of ten candidate genes in autism by association and linkage

1 reference

12 December 2020

The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins

1 reference

12 December 2020

Small GTPase Cdc42 Is Required for Multiple Aspects of Dendritic Morphogenesis

1 reference

12 December 2020

Intestinal anaerobic bacteria and autistic mind: is there some relations? Comment to: the autistic mind: a case study. Katarzyna Markiewicz, Bruce Duncan MacQueen. Med Sci Monit, 2009; 15(1): CS5-13.

1 reference

12 December 2020

Essential role of Rac1 and Rac3 GTPases in neuronal development

1 reference

12 December 2020

An integrated bioinformatics analysis of mouse testis protein profiles with new understanding

1 reference

12 December 2020

Rac1 inactivation by lethal toxin from Clostridium sordellii modifies focal adhesions upstream of actin depolymerization

1 reference

12 December 2020

Positional cues governing cell migration in leech neurogenesis

1 reference

12 December 2020

10.1007/S12017-013-8224-3

Identifiers

DOI

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Dimensions Publication ID

28 August 2017

1019279390

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