Oncogenic role of kinesin proteins and targeting kinesin therapy (Q38084376)

28 August 2017

title

Oncogenic role of kinesin proteins and targeting kinesin therapy (English)

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28 August 2017

Xinran Liu

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28 August 2017

Hao Gong

series ordinal

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28 August 2017

Kun Huang

series ordinal

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28 August 2017

publication date

4 April 2013

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28 August 2017

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28 August 2017

volume

104

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28 August 2017

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28 August 2017

page(s)

651-656

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Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

28 August 2017

cites work

1 reference

A standardized kinesin nomenclature

21 January 2018

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All kinesin superfamily protein, KIF, genes in mouse and human

21 January 2018

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The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain.

21 January 2018

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The road less traveled: emerging principles of kinesin motor utilization

21 January 2018

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How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays

21 January 2018

1 reference

Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers

21 January 2018

1 reference

A new oncolytic adenoviral vector carrying dual tumour suppressor genes shows potent anti‐tumour effect

21 January 2018

1 reference

Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification.

21 January 2018

1 reference

X chromosomal abnormalities in basal-like human breast cancer

21 January 2018

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Identification of a link between the tumour suppressor APC and the kinesin superfamily

21 January 2018

1 reference

Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration

21 January 2018

1 reference

A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors

21 January 2018

1 reference

KIF14 mRNA expression is a predictor of grade and outcome in breast cancer

21 January 2018

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KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer

21 January 2018

1 reference

KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers

21 January 2018

1 reference

Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer

21 January 2018

1 reference

Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes

21 January 2018

1 reference

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

21 January 2018

1 reference

Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival

21 January 2018

1 reference

Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer

21 January 2018

1 reference

Downregulation of KIF23 suppresses glioma proliferation

21 January 2018

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Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.

21 January 2018

1 reference

Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function

21 January 2018

1 reference

Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas.

21 January 2018

1 reference

Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer

21 January 2018

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Overexpression of Mitotic Centromere–Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel

21 January 2018

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The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.

21 January 2018

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Overexpression of kinesins mediates docetaxel resistance in breast cancer cells

21 January 2018

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Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes.

21 January 2018

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Tumor formation via loss of a molecular motor protein.

21 January 2018

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High expression of KIF14 in retinoblastoma: association with older age at diagnosis

21 January 2018

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Mitotic centromere-associated kinesin is important for anaphase chromosome segregation

21 January 2018

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Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.

21 January 2018

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Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer

21 January 2018

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Mutations of the APC (adenomatous polyposis coli) gene

21 January 2018

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Mammalian end binding proteins control persistent microtubule growth

21 January 2018

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MCAK associates with the tips of polymerizing microtubules

21 January 2018

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MCAK associates with EB1.

21 January 2018

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The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

21 January 2018

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Targeting of integrin beta1 and kinesin 2alpha by microRNA 183

21 January 2018

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Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer

21 January 2018

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Consensus transcriptome signature of perineural invasion in pancreatic carcinoma

21 January 2018

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Microtubules and resistance to tubulin-binding agents

21 January 2018

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Overcoming taxane and anthracycline resistance

21 January 2018

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Microtubule active agents: beyond the taxane frontier

21 January 2018

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Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer

21 January 2018

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Mitotic spindle organization by a plus-end-directed microtubule motor

21 January 2018

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Targeting the kinesin spindle protein: basic principles and clinical implications.

21 January 2018

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Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

21 January 2018

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

21 January 2018

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Kinesin motor proteins as targets for cancer therapy

21 January 2018

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Antitumor activity of a kinesin inhibitor

21 January 2018

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A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours

21 January 2018

1 reference

A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168).

21 January 2018

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Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck

21 January 2018

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A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial.

21 January 2018

1 reference

Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia

21 January 2018

1 reference

A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose

21 January 2018

1 reference

A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies

21 January 2018

1 reference

A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors

21 January 2018

1 reference

A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias

21 January 2018

1 reference

First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer

21 January 2018

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Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program

21 January 2018

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Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin.

21 January 2018

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Mitosis is not a key target of microtubule agents in patient tumors.

21 January 2018

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Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale

21 January 2018

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Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells

21 January 2018

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Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

21 January 2018

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Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL

21 January 2018

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Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E.

21 January 2018

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Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell

21 January 2018

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12 December 2020

Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo

1 reference

12 December 2020

Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis

1 reference

12 December 2020

Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis

1 reference

12 December 2020

NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer.

1 reference

12 December 2020

Phase I dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer

1 reference

12 December 2020

Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue

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12 December 2020

Overexpression of Eg5 causes genomic instability and tumor formation in mice

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12 December 2020

Targeting the kinesin Eg5 to monitor siRNA transfection in mammalian cells

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12 December 2020

Identifiers

DOI

10.1111/CAS.12138

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28 August 2017

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