Metabolic checkpoints in activated T cells (Q38044664)

27 August 2017

title

Metabolic checkpoints in activated T cells (English)

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27 August 2017

Douglas R Green

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Ruoning Wang

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27 August 2017

language of work or name

English

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publication date

18 September 2012

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27 August 2017

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27 August 2017

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27 August 2017

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27 August 2017

page(s)

907-915

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Mapping the life histories of T cells.

27 August 2017

cites work

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Overview: apoptotic signaling pathways in the immune system

21 January 2018

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The immune diet: meeting the metabolic demands of lymphocyte activation

21 January 2018

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

21 January 2018

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Metabolic pathways in T cell fate and function

21 January 2018

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The CD28 signaling pathway regulates glucose metabolism

21 January 2018

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21 January 2018

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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

21 January 2018

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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

21 January 2018

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Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells

21 January 2018

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Plasticity of CD4+ T cell lineage differentiation.

21 January 2018

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Shaping and reshaping CD8+ T-cell memory.

21 January 2018

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

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Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

21 January 2018

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Checkpoints: controls that ensure the order of cell cycle events

21 January 2018

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Cell cycle checkpoints: preventing an identity crisis

21 January 2018

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On prokaryotic intelligence: strategies for sensing the environment

21 January 2018

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Bacterial sensor kinases: diversity in the recognition of environmental signals

21 January 2018

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The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

21 January 2018

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Hypoxia-inducible factors in physiology and medicine

21 January 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

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Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors

21 January 2018

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Interdependence of hypoxic and innate immune responses

21 January 2018

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Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

21 January 2018

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HIF-1 alpha deficiency perturbs T and B cell functions.

21 January 2018

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mTOR signaling in growth control and disease

21 January 2018

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

21 January 2018

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

21 January 2018

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Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

21 January 2018

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Mammalian TOR: a homeostatic ATP sensor

21 January 2018

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

21 January 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

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Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

21 January 2018

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AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function

21 January 2018

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The liver kinase B1 is a central regulator of T cell development, activation, and metabolism

21 January 2018

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The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

21 January 2018

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21 January 2018

Mechanisms of mitophagy

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

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Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

21 January 2018

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

21 January 2018

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Tor-mediated induction of autophagy via an Apg1 protein kinase complex

21 January 2018

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Tor directly controls the Atg1 kinase complex to regulate autophagy

21 January 2018

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Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death

21 January 2018

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A critical role for the autophagy gene Atg5 in T cell survival and proliferation

21 January 2018

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Autophagy is essential for mitochondrial clearance in mature T lymphocytes

21 January 2018

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Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes

21 January 2018

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An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness.

21 January 2018

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 January 2018

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

21 January 2018

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Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

21 January 2018

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

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Coping with stress: eIF2 kinases and translational control

21 January 2018

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Dendritic cells, indoleamine 2,3 dioxygenase and acquired immune privilege

21 January 2018

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The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase

21 January 2018

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Monocyte dependent regulation of autoimmune inflammation

21 January 2018

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Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

21 January 2018

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GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

21 January 2018

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Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells

21 January 2018

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Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

21 January 2018

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Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

21 January 2018

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

21 January 2018

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An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

21 January 2018

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

21 January 2018

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Integration of metabolism and inflammation by lipid-activated nuclear receptors

21 January 2018

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

21 January 2018

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

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The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism

21 January 2018

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The nuclear receptor LXR is a glucose sensor

21 January 2018

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LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

21 January 2018

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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

21 January 2018

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Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability

21 January 2018

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Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

21 January 2018

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SIRT1 deacetylates and positively regulates the nuclear receptor LXR

21 January 2018

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NAD+ as a signaling molecule modulating metabolism

21 January 2018

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Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

21 January 2018

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Lysine acetylation: codified crosstalk with other posttranslational modifications

21 January 2018

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Regulation of intermediary metabolism by protein acetylation

21 January 2018

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On acetyl-CoA as a gauge of cellular metabolic state

21 January 2018

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Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

21 January 2018

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A continuous microplate assay for sirtuins and nicotinamide-producing enzymes

21 January 2018

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

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Reconstructing eukaryotic NAD metabolism

21 January 2018

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Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress

21 January 2018

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The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

21 January 2018

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The effect of gamma radiation and neocarzinostatin of NAD and ATP levels in mouse leukaemia cells

21 January 2018

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The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

21 January 2018

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Poly(ADP-ribose): novel functions for an old molecule

21 January 2018

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The Involvement of Poly(ADP-ribose) Polymerase in the Degradation of NAD Caused by gamma-Radiation and N-Methyl-N-Nitrosourea

21 January 2018

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

21 January 2018

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Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.

21 January 2018

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Regulation of transcription factor NFAT by ADP-ribosylation

21 January 2018

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Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

21 January 2018

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T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

21 January 2018

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FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

21 January 2018

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Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.

21 January 2018

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Deacetylase inhibition promotes the generation and function of regulatory T cells.

21 January 2018

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Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

21 January 2018

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Epigenetic control of the foxp3 locus in regulatory T cells

21 January 2018

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Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency.

21 January 2018

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Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats

21 January 2018

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Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.

21 January 2018

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The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

21 January 2018

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Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance

21 January 2018

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Calorie restriction, SIRT1 and metabolism: understanding longevity

21 January 2018

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Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice

21 January 2018

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Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis

21 January 2018

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Regulatory role of resveratrol on Th17 in autoimmune disease

21 January 2018

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Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus.

21 January 2018

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Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women

21 January 2018

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Protein serine/threonine kinases

21 January 2018

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A novel method for measurement of submembrane ATP concentration

21 January 2018

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The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway

21 January 2018

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The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

21 January 2018

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

21 January 2018

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The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells

21 January 2018

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

21 January 2018

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PKM2 enters the morpheein academy.

21 January 2018

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Pyruvate kinase type M2: a crossroad in the tumor metabolome

21 January 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

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Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells

21 January 2018

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Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes

21 January 2018

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12 December 2020

Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5

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12 December 2020

Regulation and function of mTOR signalling in T cell fate decisions

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12 December 2020

The study of metabolic compartmentalization

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12 December 2020

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation

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12 December 2020

Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice

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12 December 2020

ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver

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12 December 2020

A two-way street: reciprocal regulation of metabolism and signalling.

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12 December 2020

Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular

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12 December 2020

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

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12 December 2020

sirt1-null mice develop an autoimmune-like condition

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12 December 2020

The role of nutrition in enhancing immunity in aging

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12 December 2020

Pyridine nucleotide analog interference with metabolic processes in mitogen-stimulated human T lymphocytes

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12 December 2020

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

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12 December 2020

A role for mammalian target of rapamycin in regulating T cell activation versus anergy

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12 December 2020

Operon: a group of genes with the expression coordinated by an operator

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12 December 2020

Identifiers

DOI

10.1038/NI.2386

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27 August 2017

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