Immunotherapy for Alzheimer disease: the challenge of adverse effects. (Q38023156)

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6 February 2020

title

Immunotherapy for Alzheimer disease: the challenge of adverse effects (English)

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6 February 2020

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6 February 2020

Brian Giunta

1 reference

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6 February 2020

Jun Tan

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6 February 2020

Yu-Hui Liu

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6 February 2020

Hua-Dong Zhou

series ordinal

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6 February 2020

language of work or name

English

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publication date

3 July 2012

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6 February 2020

published in

Nature Reviews Neurology

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6 February 2020

volume

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6 February 2020

issue

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6 February 2020

page(s)

465-469

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

6 February 2020

cites work

1 reference

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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

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Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease

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Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers

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Revised criteria for diagnosis of Alzheimer's disease: National Institute on Aging‐Alzheimer's Association diagnostic guidelines for Alzheimer's disease

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Inflammaging as a prodrome to Alzheimer's disease

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Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease

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Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

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Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

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Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease

21 January 2018

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Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

21 January 2018

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Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

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Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis

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APOE {epsilon}4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics.

21 January 2018

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

21 January 2018

1 reference

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Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice

21 January 2018

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

21 January 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

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Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

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Naturally Occurring Autoantibodies against β-Amyloid: Investigating Their Role in Transgenic Animal andIn VitroModels of Alzheimer's Disease

21 January 2018

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Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neurotoxicity

21 January 2018

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Autoreactive-Aβ antibodies promote APP β-secretase processing

21 January 2018

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Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies

21 January 2018

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Molecular basis for amyloid- polymorphism

21 January 2018

1 reference

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Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

21 January 2018

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Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

21 January 2018

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Immunotherapy reduces vascular amyloid-beta in PDAPP mice.

21 January 2018

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21 January 2018

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Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta

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Conformations and biological activities of amyloid beta peptide 25-35.

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p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

21 January 2018

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Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

21 January 2018

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Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies

21 January 2018

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Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons

21 January 2018

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Modified Immunotherapies Against Alzheimer's Disease: Toward Safer and Effective Amyloid-β Clearance

21 January 2018

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Immune responsiveness to inhaled antigens: local antibody production in the respiratory tract in health and lung diseases

21 January 2018

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Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-β(1-42) deposition

31 March 2020

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Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid clearance

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22751529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRNEUROL.2012.118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22751529%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 February 2020

1018508153

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22751529%20AND%20SRC:MED&resulttype=core&format=json