Metabolism of nitro-polycyclic aromatic hydrocarbons (Q38020765)

27 August 2017

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title

Metabolism of nitro-polycyclic aromatic hydrocarbons (English)

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polycyclic aromatic hydrocarbons

27 August 2017

main subject

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Fu PP

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27 August 2017

language of work or name

English

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publication date

1 January 1990

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27 August 2017

published in

Drug Metabolism Reviews

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27 August 2017

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27 August 2017

issue

2-3

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27 August 2017

page(s)

209-268

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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

27 August 2017

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Airplane emissions: a source of mutagenic nitrated polycyclic aromatic hydrocarbons

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Mutagenicity and carcinogenicity of nitroarenes and their sources in the environment

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Mutagenic/carcinogenic agents in indoor pollutants; the dinitropyrenes generated by kerosene heaters and fuel gas and liquefied petroleum gas burners

21 January 2018

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Microbial detection of mutagenic nitro-organic compounds in filtrates of coal fly ash.

21 January 2018

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Detection of 1-nitropyrene in yakitori (grilled chicken).

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Cigarette smoking may yield nitroarenes

21 January 2018

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Mutagenicity of nitro derivatives induced by exposure of aromatic compounds to nitrogen dioxide

21 January 2018

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Nitration of naphthalene and remarks on the mechanism of electrophilic aromatic nitration

21 January 2018

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Mutagenicity and genotoxicity of nitroarenes. All nitro-containing chemicals were not created equal

21 January 2018

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Nitration of carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons results in products able to induce transformation of Syrian hamster cells

21 January 2018

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Nitrated polycyclic aromatic hydrocarbons: potent bacterial mutagens and stimulators of DNA repair synthesis in cultured human cells

21 January 2018

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Metabolism of 1-nitropyrene and formation of DNA adducts in Salmonella typhimurium.

21 January 2018

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Metabolism of 1,8-dinitropyrene by Salmonella typhimurium.

21 January 2018

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1-Nitrosopyrene: an intermediate in the metabolic activation of 1-nitropyrene to a mutagen in Salmonella typhimurium TA1538.

21 January 2018

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DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation

21 January 2018

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Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium

21 January 2018

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Cytotoxic and mutagenic effects of 1-nitropyrene and 1-nitrosopyrene in diploid human fibroblasts.

21 January 2018

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Identification and characterization of the major DNA adduct formed chemically and in vitro from the environmental genotoxin 3-nitrofluoranthene

21 January 2018

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The genetic activity of dinitropyrenes in yeast: unusual dose response curves for induced mitotic gene conversion.

21 January 2018

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Metabolism of nitroaromatic compounds

21 January 2018

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Multiple metabolic pathways for the mutagenic activation of 3-nitrobenzo[a]pyrene

21 January 2018

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Effect of the nitro group conformation on the rat liver microsomal metabolism and bacterial mutagenicity of 2- and 9-nitroanthracene

21 January 2018

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Oxidative microsomal metabolism of 1-nitropyrene and DNA-binding of oxidized metabolites following nitroreduction

21 January 2018

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The basis of the insensitivity of Salmonella typhimurium strain TA98/1,8-DNP6 to the mutagenic action of nitroarenes

21 January 2018

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Identification of the DNA adduct formed by metabolism of 1,8-dinitropyrene in Salmonella typhimurium.

21 January 2018

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Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

5-nitroacenaphthene: A newly recognized role for the nitro function in mutagenicity

21 January 2018

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Mutagenicity of metronidazole: Activation by mammalian liver microsomes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

Comparative effects of topically applied nitrated arenes and their nonnitrated parent arenes on cutaneous and hepatic drug and carcinogen metabolism in neonatal rats

21 January 2018

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Topically applied nitropyrenes are potent inducers of cutaneous and hepatic monooxygenases

21 January 2018

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DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction

21 January 2018

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Direct-acting mutagens in diesel exhausts: magnitude of the problem

21 January 2018

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Mutagens in diesel exhaust particulate. Identification and direct activities of 6-nitrobenzo[a]pyrene, 9-nitroanthracene, 1-nitropyrene and 5h-phenanthro[4,5-bcd]pyran-5-one

21 January 2018

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Mutagenicity of derivatives and metabolites of 1-nitropyrene: activation by rat liver S9 and bacterial enzymes

21 January 2018

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Mutagenicity of nitrofluoranthenes, 3-aminofluoranthene and 1-nitropyrene in Chinese hamster V79 cells

21 January 2018

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Biochemical Pharmacology of the Intestinal Flora

21 January 2018

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Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by rat intestinal bacteria.

21 January 2018

1 reference

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Mutagenic activation of biliary metabolites of 1-nitropyrene by intestinal microflora

21 January 2018

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Contribution of intestinal microfloral metabolism to the total macromolecular covalent binding of 1-nitro-pyrene in the lung and liver of the rat.

21 January 2018

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The role of the intestinal microflora in the formation of mutagenic metabolites from the carcinogenic air pollutant 2-nitrofluorene

21 January 2018

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Biotransformation of 1-nitropyrene in intestinal anaerobic bacteria

21 January 2018

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Induction of liver and lung tumours in mice by 6-aminochrysene administered during the 1st 3 days of life.

21 January 2018

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Carcinogenicity of 6-aminochrysene in mice

21 January 2018

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Carcinogenic action of 5-nitroacenaphthene

21 January 2018

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Enzymic reduction of carcinogenic aromatic nitro compounds by rat and mouse liver fractions

21 January 2018

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Metabolism of the carcinogenic air pollutant 2-nitrofluorene in the isolated perfused rat lung and liver

21 January 2018

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Correlation between induction of unscheduled DNA synthesis in the liver and excretion of mutagenic metabolites in the urine of rats exposed to the carcinogenic air pollutant 2-nitrofluorene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Nitrated polycyclic aromatic hydrocarbons in urban air particles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Liver microsomal metabolism of the environmental carcinogen 3-nitrofluoranthene. I. Phenolic metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

A rapid and simple synthesis of reactive metabolites of carcinogenic aromatic amines in high yield.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism of 9-nitroanthracene by rat liver microsomes: identification and mutagenicity of metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

The mechanism of hydrolysis of the non-K-region benzo[a]pyrene diol epoxide r-7, t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Changes of mechanisms and product distributions in the hydrolysis of benzo[a]pyrene-7,8-diol 9,10,-epoxide metabolites induced by changes in pH

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Evidence for N-(deoxyguanosin-8-yl)-1-aminopyrene as a major DNA adduct in female rats treated with 1-nitropyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Formation of DNA adducts in mouse tissues after intratracheal instillation of 1-nitropyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism and DNA binding of 1-nitropyrene and 1-nitrosopyrene in newborn mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Tumorigenicity and metabolism of 1-nitropyrene in A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Bioactivation and biotransformation of 1-nitropyrene in liver, lung and nasal tissue of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Mutagenicity of 1-nitropyrene metabolites from lung S9.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Comparison of the in vitro and in vivo hepatic metabolism of the carcinogen 1-nitropyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism of K-region derivatives of 1-nitropyrene by rat liver in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

In vivo and in vitro formation of glutathione conjugates from the K-region epoxides of 1-nitropyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Formation and fate of gaseous and particulate mutagens and carcinogens in real and simulated atmospheres

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Induction of sarcomas in rats by subcutaneous injection of dinitropyrenes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Acetyl coenzyme A-dependent binding of carcinogenic and mutagenic dinitropyrenes to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

6-Nitrochrysene is a potent tumorigen in newborn mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochr

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

The influence of methyl substitution of the mutagenicity of nitronaphthalenes and nitrobiphenyls

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Effects of 6-nitro substitution on 5-methylchrysene tumorigenicity, mutagenicity and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Comparative metabolism and DNA binding of 6-nitro-5-methylchrysene and 5-methylchrysene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Absolute stereochemistry of the trans-dihydrodiols formed from benzo[a]anthracene by liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolic activation of 3-nitroperylene in the Salmonella/S9 assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Synthesis, spectral analysis, and mutagenicity of 1-, 3-, and 6-nitrobenzo[a]pyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism of 1-nitrobenzo[a]pyrene by rat liver microsomes to potent mutagenic metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Hepatocyte-mediated mutagenicity of mononitrobenzo[a]pyrenes in Salmonella typhimurium strains

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Mutagenicity of the mononitrobenzo[a]pyrenes in Chinese hamster ovary cells mediated by rat hepatocytes or liver S9.

21 January 2018

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Binary mixtures containing isomers of nitrobenzo[a]pyrene induce greater-than-additive mutational responses in Salmonella typhimurium. I. Analysis by the total concentration-proportional mixture model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Role of nitroreduction in the synergistic mutational response induced by mixtures of 1- and 3-nitrobenzo[a]pyrene in Salmonella typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Reply to 'Comment on the Non-Additivity of the Mutagenic Response of Mixtures of Nitrobenzo[a]Pyrenes'.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Short-term bioassays of nitro derivatives of benzo[a]pyrene and perylene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism of the mutagenic environmental pollutant, 6-nitrobenzo[a]pyrene: metabolic activation via ring oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism of monohydroxybenzo(a)pyrenes by rat liver microsomes and mammalian cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Evidence for a 2,3-epoxide as an intermediate in the microsomal metabolism of 6-nitrobenzo[a]pyrene.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539009041085

Microsomal metabolism of 1-nitrobenzo[e]pyrene to a highly mutagenic K-region dihydrodiol

21 January 2018

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Structural features of nitroaromatics that determine mutagenic activity in Salmonella typhimurium

21 January 2018

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Nitroreduction of 6-nitrobenzo[a]pyrene: a potential activation pathway in humans

21 January 2018

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Relationship between polarographic reduction potential and mutagenicity of nitroarenes

21 January 2018

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Dichotomy in the mutagenicity and genotoxicity of nitropyrenes: apparent effect of the number of electrons involved in nitroreduction

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

Sequential and differing nitroreductive pathways for mutagenic nitropyrenes in Salmonella typhimurium

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

Structural requirements for the mutagenicity of environmental nitroarenes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

Metabolism of 1-nitro[14C]pyrene in vivo in the rat and mutagenicity of urinary metabolites

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

Identification of ring oxidized metabolites of 1-nitropyrene in the feces and urine of germfree F344 rats

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

Evaluation of Nitrated Polycydic Aromatic Hydrocarbons in Anthropogenic Emission and Air Samples: A Possible Means of Detecting Reactions of Carbonaceous Particles in the Atmosphere

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602539009041085

Ubiquitous occurrence of 2-nitrofluoranthene and 2-nitropyrene in air

21 January 2018

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10.3109/03602539009041085

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference