Advances in LC platforms for drug discovery (Q38028548)

27 August 2017

title

Advances in LC platforms for drug discovery (English)

1 reference

27 August 2017

1 reference

Jean-Luc Wolfender

0 references

Pierre-Alain Carrupt

1 reference

27 August 2017

Serge Rudaz

1 reference

27 August 2017

Davy Guillarme

1 reference

27 August 2017

Jean-Luc Veuthey

1 reference

27 August 2017

Raul Nicoli

1 reference

27 August 2017

Sophie Martel

1 reference

27 August 2017

language of work or name

English

0 references

publication date

5 April 2010

1 reference

Expert Opinion on Drug Discovery

27 August 2017

published in

1 reference

27 August 2017

1 reference

27 August 2017

1 reference

27 August 2017

page(s)

475-489

1 reference

Hit and lead generation: beyond high-throughput screening

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Novel trends in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

The evolving role of natural products in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Pharmacokinetics and metabolism in early drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Pharmaceutical profiling in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Principles and applications of LC-MS in new drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Analysis and screening of combinatorial libraries using mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Open-access liquid chromatography/mass spectrometry in a drug discovery environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Applications of high-throughput ADME in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

High throughput physicochemical profiling for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Applications of silica-based monolithic HPLC columns

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Fast analysis in liquid chromatography using small particle size and high pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Method transfer for fast liquid chromatography in pharmaceutical analysis: application to short columns packed with small particle. Part I: isocratic separation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Some solutions to obtain very efficient separations in isocratic and gradient modes using small particles size and ultra-high pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Liquid chromatography-mass spectrometry in in vitro drug metabolite screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Mass spectrometry and combinatorial chemistry: a short outline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Modern methods to produce natural-product libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

A method for the production and characterization of fractionated libraries from Chinese herbal formulas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

UPLC-TOF-MS for plant metabolomics: a sequential approach for wound marker analysis in Arabidopsis thaliana

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Developing a drug-like natural product library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Anti-cancer natural product library from traditional chinese medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

High-throughput lipophilicity measurement with immobilized artificial membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Evaluation of in vitro brain penetration: optimized PAMPA and MDCKII-MDR1 assay comparison.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Separation methods for estimating octanol-water partition coefficients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Determination of lipophilicity by reversed-phase high-performance liquid chromatography. Influence of 1-octanol in the mobile phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Effect of n-octanol in the mobile phase on lipophilicity determination by reversed-phase high-performance liquid chromatography on a modified silica column

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Lipophilicity measurement of drugs by reversed phase HPLC over Wide pH range using an alkaline-resistant silica-based stationary phase, XBridge Shield RP(18).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Method for measuring the logarithm of the octanol-water partition coefficient by using short octadecyl-poly(vinyl alcohol) high-performance liquid chromatography columns

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

The effect of stationary phase on lipophilicity determination of beta-blockers using reverse-phase chromatographic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Lipophilicity determination of highly lipophilic compounds by liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

High-throughput liquid chromatography/mass spectrometry method for the determination of the chromatographic hydrophobicity index.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

High-throughput logP measurement using parallel liquid chromatography/ultraviolet/mass spectrometry and sample-pooling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

High-throughput pKa screening and prediction amenable for ADME profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

pH gradient high-performance liquid chromatography: theory and applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Simultaneous determination of LogD, LogP, and pK(a) of drugs by using a reverse phase HPLC coupled with a 96-well plate auto injector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Biopartitioning micellar separation methods: modelling drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Immobilized artificial membrane HPLC in drug research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Prediction of oral absorption in humans by experimental immobilized artificial membrane chromatography indices and physicochemical descriptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Rapid screening of blood-brain barrier penetration of drugs using the immobilized artificial membrane phosphatidylcholine column chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Chromatographic retention of drug molecules on immobilised liposomes prepared from egg phospholipids and from chemically pure phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Potential of biopartitioning micellar chromatography as an in vitro technique for predicting drug penetration across the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Rapid in vitro test to predict ocular tissue permeability based on biopartitioning micellar chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Characterization of biopartitioning micellar chromatography system using monolithic column by linear solvation energy relationship and application to predict blood-brain barrier penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

ADME optimization and toxicity assessment in early- and late-phase drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Development of an in-capillary approach to nanoscale automated in vitro cytochromes p450 assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Addressing the analytical throughput challenges in ADME screening using rapid ultra-performance liquid chromatography/tandem mass spectrometry methodologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

In vitro metabolite identification using fast gradient high performance liquid chromatography combined with tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

A review of current trends and advances in modern bio-analytical methods: chromatography and sample preparation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Ultra-performance liquid chromatography/tandem mass spectrometric quantification of structurally diverse drug mixtures using an ESI-APCI multimode ionization source

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Coupling ultra high-pressure liquid chromatography with single quadrupole mass spectrometry for the analysis of a complex drug mixture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Comparison of fused-core and conventional particle size columns by LC-MS/MS and UV: application to pharmacokinetic study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

The advantages of ESI-MS detection in conjunction with HILIC mode separations: Fundamentals and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of drug metabolites (xenometabolome) in epidemiological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

A practical guide to nano-LC troubleshooting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Microfluidic chip for peptide analysis with an integrated HPLC column, sample enrichment column, and nanoelectrospray tip.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography–mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Biopartitioning micellar chromatography: an in vitro technique for predicting human drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

The importance of hyphenated techniques in the discovery of new lead compounds from nature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Optimized liquid chromatography–mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003733874

Chromatographic behaviour and comparison of column packed with sub-2 microm stationary phases in liquid chromatography

21 January 2018

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Novel RPLC stationary phases for lipophilicity measurement: solvatochromic analysis of retention mechanisms for neutral and basic compounds

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Ultrahigh-pressure reversed-phase capillary liquid chromatography: isocratic and gradient elution using columns packed with 1.0-micron particles

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Fast Determination of Lipophilicity by HPLC

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Lipophilicity of basic drugs measured by hydrophilic interaction chromatography

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Evaluation of the properties of a superficially porous silica stationary phase in hydrophilic interaction chromatography

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Fused-core particle technology as an alternative to sub-2-microm particles to achieve high separation efficiency with low backpressure

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Pharmaceutical applications on columns packed with sub-2 microm particles.

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Novel generic UPLC/MS/MS method for high throughput analysis applied to permeability assessment in early Drug Discovery

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Evaluation of various HILIC materials for the fast separation of polar compounds

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Characterization of chromatographic supports for the analysis of basic compounds

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Method transfer for fast liquid chromatography in pharmaceutical analysis: application to short columns packed with small particle. Part II: gradient experiments

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

MSE with mass defect filtering for in vitro and in vivo metabolite identification

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Sub one minute inhibition assays for the major cytochrome P450 enzymes utilizing ultra-performance liquid chromatography/tandem mass spectrometry

1 reference

25 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Chromatographic Performance of Silica-Based Stationary Phases in High Temperature Liquid Chromatography: Pharmaceutical Applications

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Advancing LC Performance with Smaller Particles and Higher Pressure

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Progress in the Use of HPLC for Evaluation of Lipophilicity

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

UPLC™: An Introduction and Review

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Lipophilicity Measurement by Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC): A Comparison of Two Stationary Phases Based on Retention Mechanisms

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

The Inject-Mix-React-Separate-and-Quantitate (IMReSQ) approach to studying reactions in capillaries

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Coupling ultra-high-pressure liquid chromatography with mass spectrometry

1 reference

27 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/17460441003733874

Identifiers

DOI

10.1517/17460441003733874

1 reference

27 August 2017

1 reference