MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy (Q38026589)

27 August 2017

title

MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy (English)

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27 August 2017

Steffan T Nawrocki

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27 August 2017

Patrick Griffin

series ordinal

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27 August 2017

Kevin R Kelly

series ordinal

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27 August 2017

Jennifer S Carew

series ordinal

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27 August 2017

language of work or name

English

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publication date

16 July 2012

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Expert Opinion on Investigational Drugs

27 August 2017

published in

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27 August 2017

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27 August 2017

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27 August 2017

page(s)

1563-1573

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Narrative review: protein degradation and human diseases: the ubiquitin connection

27 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers

21 January 2018

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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Molecular and cellular effects of NEDD8-activating enzyme inhibition in myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

Age and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.707192

10.1517/13543784.2012.707192

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

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