Signaling to cardiac hypertrophy: insights from human and mouse RASopathies. (Q38009216)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576369%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Signaling to cardiac hypertrophy: insights from human and mouse RASopathies (English)

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1 February 2020

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1 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576369%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576369%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Christian Leo

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1 February 2020

Stefano Gatti

series ordinal

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1 February 2020

Bruce D Gelb

series ordinal

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1 February 2020

language of work or name

English

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publication date

7 September 2012

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1 February 2020

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1 February 2020

volume

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1 February 2020

page(s)

938-947

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Creative Commons Attribution 4.0 International

1 February 2020

start time

4 May 2012

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Ras reduces L-type calcium channel current in cardiac myocytes. Corrective effects of L-channels and SERCA2 on [Ca(2+)](i) regulation and cell morphology

6 September 2017

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6 September 2017

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CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

6 September 2017

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Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro

6 September 2017

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Myosin heavy chain isoform expression in the failing and nonfailing human heart

6 September 2017

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Gq signaling in cardiac adaptation and maladaptation

6 September 2017

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A family of cAMP-binding proteins that directly activate Rap1

6 September 2017

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

6 September 2017

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

6 September 2017

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Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function

6 September 2017

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The neurofibromatosis type 1 gene encodes a protein related to GAP

6 September 2017

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Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations

6 September 2017

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Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling

14 September 2017

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

14 September 2017

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The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

14 September 2017

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Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Differential gene expression and genomic patient stratification following left ventricular assist device support

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Clinical, pathological, and molecular analyses of cardiovascular abnormalities in Costello syndrome: a Ras/MAPK pathway syndrome.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Polyhydramnios, fetal overgrowth, and macrocephaly: prenatal ultrasound findings of Costello syndrome.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

A new G(q)-initiated MAPK signaling pathway in the heart.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

31 August 2018

1 reference

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cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Identification and regulation of Sprouty1, a negative inhibitor of the ERK cascade, in the human heart

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Urotensin II promotes hypertrophy of cardiac myocytes via mitogen-activated protein kinases

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Myocardial Gene Expression Associated with Genetic Cardiac Hypertrophy in the Absence of Hypertension

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Extracellular Signal-regulated Kinase Plays an Essential Role in Hypertrophic Agonists, Endothelin-1 and Phenylephrine-induced Cardiomyocyte Hypertrophy

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459479

Further delineation of the phenotype resulting from BRAF or MEK1 germline mutations helps differentiate cardio-facio-cutaneous syndrome from Costello syndrome

3 December 2018

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00512

Gq-coupled receptor signaling in pathological ventricular remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00512

Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00512

Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population

31 March 2020

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00512

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

31 March 2020

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00512

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.2119%2FMOLMED.2011.00512

Interaction and stabilization of X-linked inhibitor of apoptosis by Raf-1 protein kinase

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22576369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Congestive heart failure: fifty years of progress

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22576369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2119/MOLMED.2011.00512

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576369%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576369%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22576369

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22576369%20AND%20SRC:MED&resulttype=core&format=json