The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human (Q38008484)

26 August 2017

title

The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human (English)

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26 August 2017

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Tommy B Andersson

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26 August 2017

Kajsa P Kanebratt

series ordinal

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26 August 2017

John Gerry Kenna

series ordinal

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26 August 2017

language of work or name

English

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publication date

8 May 2012

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Expert Opinion on Drug Metabolism & Toxicology

26 August 2017

published in

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26 August 2017

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26 August 2017

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26 August 2017

page(s)

909-920

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describes a project that uses

26 August 2017

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Infection of a human hepatoma cell line by hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Origin and characterization of a human bipotent liver progenitor cell line

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

CYP4A11 is repressed by retinoic acid in human liver cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Comparative Gene Expression Profiles Induced by PPARγ and PPARα/γ Agonists in Human Hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Membrane transporters in drug development

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Hepatocyte polarization is essential for the productive entry of the hepatitis B virus

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Prediction of clinical CYP3A4 induction using cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

The Use of HepaRG and Human Hepatocyte Data in Predicting CYP Induction Drug-Drug Interactions via Static Equation and Dynamic Mechanistic Modelling Approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity Δσ

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Managing the challenge of chemically reactive metabolites in drug development.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Drug-induced hepatotoxicity.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Cytochrome P450-Dependent Metabolism in HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

The HepaRG cell line is suitable for bioartificial liver application

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2012.685159

Human Hepatoma HepaRG Cell Line Engraftment in Severe Combined Immunodeficient × Beige Mice Using Mouse-Specific Anti-Fas Antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2012.685159

10.1517/17425255.2012.685159

21 January 2018

Identifiers

DOI

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26 August 2017

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