Illuminating the functional and structural repertoire of human TBC/RABGAPs. (Q37976530)

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20 January 2020

title

Illuminating the functional and structural repertoire of human TBC/RABGAPs (English)

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20 January 2020

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20 January 2020

Marieke A M Frasa

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20 January 2020

Katja T Koessmeier

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20 January 2020

M Reza Ahmadian

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20 January 2020

publication date

18 January 2012

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Nature Reviews Molecular Cell Biology

20 January 2020

published in

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20 January 2020

volume

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issue

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20 January 2020

page(s)

67-73

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Rab GTPases as coordinators of vesicle traffic

20 January 2020

cites work

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Derailed endocytosis: an emerging feature of cancer

31 March 2020

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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

31 March 2020

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Current knowledge of the large RhoGAP family of proteins

31 March 2020

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GEFs and GAPs: critical elements in the control of small G proteins

31 March 2020

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TBC proteins: GAPs for mammalian small GTPase Rab?

31 March 2020

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Functional dissection of Rab GTPases involved in primary cilium formation

31 March 2020

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The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway

31 March 2020

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Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

31 March 2020

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Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.

31 March 2020

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EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin

31 March 2020

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EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis

31 March 2020

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Network organization of the human autophagy system

31 March 2020

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OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

31 March 2020

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Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases

31 March 2020

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Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

31 March 2020

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Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation

31 March 2020

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EPI64 regulates microvillar subdomains and structure

31 March 2020

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The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

31 March 2020

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Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling

31 March 2020

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Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

31 March 2020

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Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation

31 March 2020

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Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation

31 March 2020

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A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

31 March 2020

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R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population

31 March 2020

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TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition

31 March 2020

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Membrane and juxtamembrane targeting by PH and PTB domains

31 March 2020

1 reference

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

31 March 2020

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Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs.

31 March 2020

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A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway

31 March 2020

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Rab conversion as a mechanism of progression from early to late endosomes

31 March 2020

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Regulation of endocytic traffic by Rho GTPases.

31 March 2020

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Rab35 controls actin bundling by recruiting fascin as an effector protein.

31 March 2020

1 reference

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

31 March 2020

1 reference

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

31 March 2020

1 reference

Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene

31 March 2020

1 reference

At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity

31 March 2020

1 reference

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

31 March 2020

1 reference

Identification of EPI64 as a GTPase-activating protein specific for Rab27A

31 March 2020

1 reference

Arf GAPs and membrane traffic

31 March 2020

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A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24.

31 March 2020

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TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy

31 March 2020

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Identification of frequently mutated genes with relevance to nonsense mediated mRNA decay in the high microsatellite instability cancers

31 March 2020

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The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton

31 March 2020

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An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits

31 March 2020

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Interphase cytogenetic analysis of distinct X-chromosomal translocation breakpoints in synovial sarcoma

31 March 2020

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USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst

31 March 2020

1 reference

TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.

31 March 2020

1 reference

High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.

31 March 2020

1 reference

Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages

31 March 2020

1 reference

Grtp1, a novel gene regulated by growth hormone

31 March 2020

1 reference

Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis.

31 March 2020

1 reference

Serological cloning of PARIS-1: a new TBC domain-containing, immunogenic tumor antigen from a prostate cancer cell line

31 March 2020

1 reference

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication

31 March 2020

1 reference

A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication

31 March 2020

1 reference

An integrated approach to uncover drivers of cancer.

31 March 2020

1 reference

Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration

31 March 2020

1 reference

The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking

31 March 2020

1 reference

A GTPase-activating protein controls Rab5 function in endocytic trafficking

31 March 2020

1 reference

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

31 March 2020

1 reference

Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence

31 March 2020

1 reference

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity

31 March 2020

1 reference

rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome

31 March 2020

1 reference

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity

31 March 2020

1 reference

The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11.

31 March 2020

1 reference

Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene

31 March 2020

1 reference

TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.

31 March 2020

1 reference

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

31 March 2020

1 reference

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

31 March 2020

1 reference

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

31 March 2020

1 reference

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells

31 March 2020

1 reference

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

31 March 2020

1 reference

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

31 March 2020

1 reference

A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint

31 March 2020

1 reference

Diversity of human copy number variation and multicopy genes

31 March 2020

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Activation of an oncogenic TBC1D7 (TBC1 domain family, member 7) protein in pulmonary carcinogenesis

31 March 2020

1 reference

12 December 2020

GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila

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12 December 2020

The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome

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12 December 2020

PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.

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12 December 2020

A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells

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12 December 2020