The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance (Q37974553)

26 August 2017

title

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance (English)

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26 August 2017

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Shawn Winer

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26 August 2017

Daniel A Winer

series ordinal

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26 August 2017

publication date

10 January 2012

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Immunology & Cell Biology

26 August 2017

published in

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26 August 2017

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26 August 2017

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26 August 2017

page(s)

755-762

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Childhood obesity, other cardiovascular risk factors, and premature death

26 August 2017

cites work

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Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

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Normalization of obesity-associated insulin resistance through immunotherapy

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Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue

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Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

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Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

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Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity

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IL-17 regulates adipogenesis, glucose homeostasis, and obesity

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Interleukin-17 family members and inflammation

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Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.

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7 January 2021

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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7 January 2021

Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers

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7 January 2021

Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients

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Interleukin-10 is a protective factor against diet-induced insulin resistance in liver

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An essential role of the transcription factor GATA-3 for the function of regulatory T cells

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IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

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7 January 2021

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

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7 January 2021

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7 January 2021

B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae

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7 January 2021

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7 January 2021

A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes

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7 January 2021

Autoantibodies in type 2 diabetes induce stress fiber formation and apoptosis in endothelial cells.

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7 January 2021

Sera from patients with type 2 diabetes contain agonistic autoantibodies against G protein-coupled receptors

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7 January 2021

Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance

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7 January 2021

Clinical and laboratory aspects of Ro/SSA-52 autoantibodies

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Toll-like receptors regulate B cell cytokine production in patients with diabetes

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7 January 2021

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

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7 January 2021

A crucial role for adipose tissue p53 in the regulation of insulin resistance

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7 January 2021

Dynamics of fat cell turnover in humans

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7 January 2021

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

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7 January 2021

Adipocyte death, adipose tissue remodeling, and obesity complications

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7 January 2021

Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis

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7 January 2021

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice

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7 January 2021

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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7 January 2021

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

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7 January 2021

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

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7 January 2021

Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue

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7 January 2021

TLR4 links innate immunity and fatty acid-induced insulin resistance

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7 January 2021

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

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7 January 2021

Inflammasome is a central player in the induction of obesity and insulin resistance

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7 January 2021

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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7 January 2021

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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7 January 2021

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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7 January 2021

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

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7 January 2021

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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7 January 2021

Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders

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7 January 2021

Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance

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7 January 2021

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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7 January 2021

The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

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7 January 2021

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

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7 January 2021

Bariatric surgery reduces visceral adipose inflammation and improves endothelial function in type 2 diabetic mice

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7 January 2021

Identifiers

DOI

10.1038/ICB.2011.110

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26 August 2017

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