Bugs, drugs and chemical genomics (Q37968877)

26 August 2017

title

Bugs, drugs and chemical genomics (English)

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26 August 2017

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26 August 2017

Terry Roemer

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26 August 2017

Julian Davies

series ordinal

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26 August 2017

Guri Giaever

series ordinal

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26 August 2017

publication date

15 December 2011

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26 August 2017

published in

Nature Chemical Biology

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26 August 2017

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26 August 2017

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26 August 2017

page(s)

46-56

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Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

26 August 2017

cites work

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Invasive methicillin-resistant Staphylococcus aureus infections in the United States

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Exploiting genomics, genetics and chemistry to combat antibiotic resistance.

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

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How to discover new antibiotics: harvesting the parvome

21 January 2018

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Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

21 January 2018

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Renaissance in antibacterial discovery from actinomycetes

21 January 2018

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Confronting the Challenges of Natural Product-Based Antifungal Discovery

21 January 2018

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Antibiotic adjuvants: multicomponent anti-infective strategies.

21 January 2018

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The art and design of genetic screens: Escherichia coli

21 January 2018

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The origin of the Haitian cholera outbreak strain

21 January 2018

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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Functional profiling of the Saccharomyces cerevisiae genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Why are there still over 1000 uncharacterized yeast genes?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Simultaneous identification of bacterial virulence genes by negative selection.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Quantitative phenotyping via deep barcode sequencing.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genomic profiling of drug sensitivities via induced haploinsufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

21 January 2018

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The chemical genomic portrait of yeast: uncovering a phenotype for all genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Yeast chemical genomics and drug discovery: an update

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

How antibiotics kill bacteria: from targets to networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genome-wide requirements for resistance to functionally distinct DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Targeted selection of recombinant clones through gene dosage effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

An integrated platform of genomic assays reveals small-molecule bioactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Compound prioritization methods increase rates of chemical probe discovery in model organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Yeast ATP-binding cassette transporters: cellular cleaning pumps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Targeting vesicle trafficking: an important approach to cancer chemotherapy.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Subcellular localization and activity of multidrug resistance proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Essential gene identification and drug target prioritization in Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

21 January 2018

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Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Isolation, structure elucidation, and biological activity of virgineone from Lachnum Wirgineum using the genome-wide Candida albicans fitness test

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Chemical genomic approaches to study model microbes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Phenotypic landscape of a bacterial cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genetic architecture of intrinsic antibiotic susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: generating an antibiotic bar code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

The neglected intrinsic resistome of bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

High-frequency transposition for determining antibacterial mode of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Wall teichoic acid function, biosynthesis, and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

The Zwitterionic Cell Wall Teichoic Acid of Staphylococcus aureus Provokes Skin Abscesses in Mice by a Novel CD4+ T-Cell-Dependent Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

A universal TagModule collection for parallel genetic analysis of microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genomewide screening for novel genetic variations associated with ciprofloxacin resistance in Bacillus anthracis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

Lack of Wall Teichoic Acids inStaphylococcus aureusLeads to Reduced Interactions with Endothelial Cells and to Attenuated Virulence in a Rabbit Model of Endocarditis

21 January 2018

1 reference

12 December 2020

A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds

1 reference

12 December 2020

The garden of antimicrobial delights

1 reference

12 December 2020

Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections

1 reference

12 December 2020

Whither antibacterial drug discovery?

1 reference

12 December 2020

Are essential genes really essential?

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

7 January 2021

inferred from DOI database lookup

Correction: Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.744

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.744

1 reference

Dimensions Publication ID

26 August 2017

1028522948

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1 reference