Preclinical perspective of urinary biomarkers for the detection of nephrotoxicity: what we know and what we need to know (Q37959015)

25 August 2017

title

Preclinical perspective of urinary biomarkers for the detection of nephrotoxicity: what we know and what we need to know (English)

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25 August 2017

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Tobias Christian Fuchs

series ordinal

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25 August 2017

Philip Hewitt

series ordinal

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25 August 2017

publication date

1 December 2011

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25 August 2017

published in

Biomarkers in Medicine

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

763-779

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A history of diabetes mellitus or how a disease of the kidneys evolved into a kidney disease.

25 August 2017

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Assessment of renal injury in vivo

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Measurement of cystatin-C and creatinine in urine

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Cystatin C--a new marker of glomerular filtration rate in children independent of age and height

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Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury

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Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration

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Release of soluble ICAM-1 from human lung fibroblasts, aortic smooth muscle cells, dermal microvascular endothelial cells, bronchial epithelial cells, and keratinocytes

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Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells

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Effects of methotrexate on trophoblast proliferation and local immune responses

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Involvement of the cell surface-bound mucin, episialin/MUC1, in progression of human carcinomas

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Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex

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A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.

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Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components

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Characterization of renal papillary antigen 1 (RPA-1), a biomarker of renal papillary necrosis

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Pleiotropic effects of Trefoil Factor 1 deficiency

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Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain

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Transcription factor NF-kappaB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells

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Intestinal trefoil factor confers colonic epithelial resistance to apoptosis

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Pattern of urinary proteins in experimental diabetes.

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Relationship between albuminuria and total proteinuria in systemic lupus erythematosus nephritis: diagnostic and therapeutic implications

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Serum and urinary amino acid levels in sickle cell disease

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Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers

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The lipocalin protein family: structural and sequence overview

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The Ngal reporter mouse detects the response of the kidney to injury in real time

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Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery

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Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers.

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Validation of putative genomic biomarkers of nephrotoxicity in rats

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Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis

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Elevation of serum and urine levels of TIMP-1 and tenascin in patients with renal disease

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Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease.

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Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure.

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Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene

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Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies

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Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury

21 January 2018

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21 January 2018

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Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity

21 January 2018

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Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium

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21 January 2018

Identifiers

DOI

10.2217/BMM.11.86

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25 August 2017

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