Genetic and epigenetic effects of environmental arsenicals (Q37942796)

25 August 2017

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title

Genetic and epigenetic effects of environmental arsenicals (English)

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25 August 2017

Catherine B. Klein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21976018

13 December 2024

Toby G. Rossman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21976018

13 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21976018

13 December 2024

publication date

5 October 2011

1 reference

full work available at URL

25 August 2017

http://pubs.rsc.org/en/content/articlepdf/2011/MT/C1MT00074H

1 reference

13 December 2024

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

1135-1141

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Experimental and theoretical characterization of arsenite in water: insights into the coordination environment of As-O.

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Polynucleotide phosphorylase and mitochondrial ATP synthase mediate reduction of arsenate to the more toxic arsenite by forming arsenylated analogues of ADP and ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Aquaglyceroporins and metalloid transport: implications in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Evidence against the nuclear in situ binding of arsenicals--oxidative stress theory of arsenic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Further evidence against a direct genotoxic mode of action for arsenic-induced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: Induction of chromosomal mutations but not gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Endonuclease III, formamidopyrimidine-DNA glycosylase, and proteinase K additively enhance arsenic-induced DNA strand breaks in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

8-Oxoguanine DNA glycosylase and MutY homolog are involved in the incision of arsenite-induced DNA adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Gene Damage Induced in Human Alveolar Type II (L-132) Cells by Exposure to Dimethylarsinic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Nitric oxide production by arsenite

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Aneugenic effect of sodium arsenite on human lymphocytes in vitro: an individual susceptibility effect detected.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Early induction of genetic instability and apoptosis by arsenic in cultured Chinese hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Insights into the carcinogenic mode of action of arsenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenite inhibits mitotic division and perturbs spindle dynamics in HeLa S3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Trivalent arsenic inhibits the functions of chaperonin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Modulation of DNA repair processes by arsenic and selenium compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Attenuation of DNA damage-induced p53 expression by arsenic: a possible mechanism for arsenic co-carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenite-induced alterations of DNA photodamage repair and apoptosis after solar-simulation UVR in mouse keratinocytes in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Chronic Exposure to Arsenic Causes Increased Cell Survival, DNA Damage, and Increased Expression of Mitochondrial Transcription Factor A (mtTFA) in Human Prostate Epithelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic and urinary bladder cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

p53 stabilization and transactivation by a von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Effects of arsenic on maternal and fetal health

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Maternal arsenic exposure associated with low birth weight in Bangladesh

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic Exposure and Risk of Spontaneous Abortion, Stillbirth, and Infant Mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Kidney cancer mortality: fifty-year latency patterns related to arsenic exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic, Stem Cells, and the Developmental Basis of Adult Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic: extension of its endocrine disruption potential to interference with estrogen receptor-mediated signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic as an endocrine disruptor: arsenic disrupts retinoic acid receptor-and thyroid hormone receptor-mediated gene regulation and thyroid hormone-mediated amphibian tail metamorphosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic-induced aberrant gene expression in fetal mouse primary liver-cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Impact of early developmental arsenic exposure on promotor CpG-island methylation of genes involved in neuronal plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

DNA Methylation and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Transformation by inorganic arsenic compounds of normal Syrian hamster embryo cells into a neoplastic state in which they become anchorage-independent and cause tumors in newborn hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenic salts induced autophagic cell death and hypermethylation of DAPK promoter in SV-40 immortalized human uroepithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Long term low-dose arsenic exposure induces loss of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Epigenetic changes of DNA repair genes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Epigenetic changes in individuals with arsenicosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Influence of oxygen radical injury on DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Arsenite alters global histone H3 methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Epigenetic remodeling during arsenical-induced malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Quantitative mass spectrometry reveals the epigenome as a target of arsenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

An Emerging Role for Epigenetic Dysregulation in Arsenic Toxicity and Carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Histone modifications and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Epigenetics and chemical safety assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

21 January 2018

miRNAs in human cancer

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

MicroRNA responses to cellular stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Synergistic apoptosis induction in leukemic cells by miR-15a/16-1 and arsenic trioxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

microRNA expression alteration after arsenic trioxide treatment in HepG-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Carcinogen Exposure and Epigenetic Silencing in Bladder Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00074H

Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction

21 January 2018

1 reference

Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols

13 December 2024

1 reference

Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase

13 December 2024

1 reference

Tumour suppression by p53: a role for the DNA damage response?

13 December 2024

1 reference

Effects of arsenic and UVB on normal human cultured keratinocytes: impact on apoptosis and implication on photocarcinogenesis

13 December 2024

1 reference

Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

13 December 2024

1 reference

Regulation of p53 sequence-specific DNA-binding by covalent poly(ADP-ribosyl)ation

13 December 2024

1 reference

Analysis of genomic dose-response information on arsenic to inform key events in a mode of action for carcinogenicity

13 December 2024

1 reference

Environmental Health Perspectives

13 December 2024

series ordinal

author name string

States

publication date

2011

1 reference

Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults

13 December 2024

1 reference

S-adenosyl-L-methionine counteracts mitotic disturbances and cytostatic effects induced by sodium arsenite in HeLa cells

13 December 2024

1 reference

Environmental Health Perspectives

13 December 2024

series ordinal

111

author name string

Cantone

publication date

2011

1 reference

13 December 2024

Identifiers

DOI

10.1039/C1MT00074H

1 reference

25 August 2017

1 reference