Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward (Q37941544)

25 August 2017

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title

Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward (English)

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25 August 2017

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David Y Lai

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25 August 2017

publication date

30 September 2011

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Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

25 August 2017

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

1-15

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Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area

25 August 2017

cites work

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Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

21 January 2018

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Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene

21 January 2018

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Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles

21 January 2018

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Measuring particle size-dependent physicochemical structure in airborne single walled carbon nanotube agglomerates

21 January 2018

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Surface reactivity in the pathogenic response to particulates

21 January 2018

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Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines

21 January 2018

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Interactions between ultrafine particles and transition metals in vivo and in vitro

21 January 2018

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Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles

21 January 2018

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Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappa B, and Akt in normal and malignant human mesothelial cells

21 January 2018

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The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types

21 January 2018

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Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing

21 January 2018

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Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage

21 January 2018

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Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

21 January 2018

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Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties

21 January 2018

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Toxicity of metal oxide nanoparticles in mammalian cells

21 January 2018

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Dust overloading of the lungs: update and appraisal

21 January 2018

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Nanoparticle cytotoxicity depends on intracellular solubility: comparison of stabilized copper metal and degradable copper oxide nanoparticles

21 January 2018

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Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems

21 January 2018

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Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition

21 January 2018

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Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety

21 January 2018

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A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics

21 January 2018

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Does Nanoparticle Activity Depend upon Size and Crystal Phase?

21 January 2018

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In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what?

21 January 2018

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Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components

21 January 2018

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Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials.

21 January 2018

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Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction

21 January 2018

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Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes

21 January 2018

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Oops they did it again! Carbon nanotubes hoax scientists in viability assays

21 January 2018

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Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique

21 January 2018

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Interactions of aluminum nanoparticles with human epidermal keratinocytes

21 January 2018

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Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles

21 January 2018

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Perturbational profiling of nanomaterial biologic activity

21 January 2018

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A 21st century paradigm for evaluating the health hazards of nanoscale materials?

21 January 2018

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Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy

21 January 2018

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Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management.

21 January 2018

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Nanomaterials for environmental studies: classification, reference material issues, and strategies for physico-chemical characterisation

21 January 2018

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Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation

21 January 2018

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Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months

21 January 2018

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Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

21 January 2018

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Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice

21 January 2018

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New approaches for the evaluation of pulmonary toxicity: bronchoalveolar lavage fluid analysis

21 January 2018

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Respiratory toxicity of multi-wall carbon nanotubes

21 January 2018

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Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx

21 January 2018

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Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats

21 January 2018

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Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

21 January 2018

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Toxicogenomics in risk assessment: applications and needs

21 January 2018

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Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast

21 January 2018

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Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles

21 January 2018

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Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway

21 January 2018

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Mechanistic toxicity assessment of nanomaterials by whole-cell-array stress genes expression analysis

21 January 2018

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Toxicogenomics to improve comprehension of the mechanisms underlying responses of in vitro and in vivo systems to nanomaterials: a review

21 January 2018

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Self-organizing map analysis of toxicity-related cell signaling pathways for metal and metal oxide nanoparticles

21 January 2018

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A new approach to the toxicity testing of carbon-based nanomaterials--the clonogenic assay

21 January 2018

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Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics

21 January 2018

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Toxicity assessment of nanomaterials: methods and challenges

21 January 2018

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Understanding biophysicochemical interactions at the nano-bio interface

21 January 2018

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Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA.

21 January 2018

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Analytical methods to assess nanoparticle toxicity

21 January 2018

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Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

21 January 2018

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Risk assessment of engineered nanomaterials and nanotechnologies--a review

21 January 2018

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Toxicity testing in the 21st century: bringing the vision to life

21 January 2018

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Modeling the in vivo case with in vitro nanotoxicity data

21 January 2018

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ToxCast on target: in vitro assays and computer modeling show promise for screening chemicals

21 January 2018

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Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment

21 January 2018

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Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/WNAN.162

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25 August 2017

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