The influence of the 'organizational factor' on compound quality in drug discovery (Q37940789)

25 August 2017

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title

The influence of the 'organizational factor' on compound quality in drug discovery (English)

1 reference

25 August 2017

1 reference

Paul D. Leeson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21959288

13 December 2024

Stephen A. St-Gallay

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21959288

13 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21959288

13 December 2024

publication date

30 September 2011

1 reference

full work available at URL

25 August 2017

http://www.nature.com/articles/nrd3552.pdf

1 reference

https://api.crossref.org/works/10.1038/NRD3552

http://www.nature.com/articles/nrd3552

13 December 2024

1 reference

https://api.crossref.org/works/10.1038/NRD3552

Nature Reviews Drug Discovery

13 December 2024

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

749-765

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

25 August 2017

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21 January 2018

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Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

21 January 2018

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Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity

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Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design

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The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates.

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Structural diversity of organic chemistry. A scaffold analysis of the CAS Registry.

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Heteroaromatic rings of the future.

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How well do medicinal chemists learn from experience?

21 January 2018

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Learning lessons from drugs that have recently entered the market

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Lessons from 60 years of pharmaceutical innovation

21 January 2018

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Designing drugs to avoid toxicity

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Structural alerts, reactive metabolites, and protein covalent binding: how reliable are these attributes as predictors of drug toxicity?

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A review of the electrophilic reaction chemistry involved in covalent DNA binding

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The resurgence of covalent drugs

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The productivity crisis in pharmaceutical R&D.

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Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

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Selectively nonselective kinase inhibition: striking the right balance

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Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

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Drug discovery: A question of library design

21 January 2018

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

21 January 2018

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Evaluation of human pharmacokinetics, therapeutic dose and exposure predictions using marketed oral drugs

31 March 2020

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Generation of a set of simple, interpretable ADMET rules of thumb

31 March 2020

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Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

31 March 2020

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Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds

31 March 2020

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Investigation of the Relationship between Topology and Selectivity for Druglike Molecules

31 March 2020

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination

31 March 2020

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Development of specific "drug-like property" rules for carboxylate-containing oral drug candidates

31 March 2020

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31 March 2020

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Are there differences between launched drugs, clinical candidates, and commercially available compounds?

31 March 2020

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The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds

31 March 2020

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The influence of lead discovery strategies on the properties of drug candidates

31 March 2020

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Dependence of molecular properties on proteomic family for marketed oral drugs

31 March 2020

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Ligand binding efficiency: trends, physical basis, and implications

31 March 2020

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Enthalpic Efficiency of Ligand Binding

31 March 2020

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Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships

31 March 2020

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Getting pharmaceutical R&D back on target

31 March 2020

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Valuation benefits of structure-enabled drug discovery

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21959288

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Design of Leadlike Combinatorial Libraries

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21959288

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21959288

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3552

1 reference

Dimensions Publication ID

25 August 2017

1019542495

0 references

1 reference