The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases (Q37944146)

25 August 2017

title

The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases (English)

1 reference

25 August 2017

0 references

Richard H Siggers

1 reference

25 August 2017

David J Hackam

series ordinal

1 reference

25 August 2017

publication date

11 October 2011

1 reference

Cellular and Molecular Life Sciences

25 August 2017

published in

1 reference

25 August 2017

1 reference

25 August 2017

1 reference

25 August 2017

page(s)

3623-3634

1 reference

Regulation of apoptosis during homeostasis and disease in the intestinal epithelium

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Cell death assays for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Apoptosis: controlled demolition at the cellular level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Molecular identification of a danger signal that alerts the immune system to dying cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The CD95 type I/type II model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

How Bacteria-Induced Apoptosis of Intestinal Epithelial Cells Contributes to Mucosal Inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Toll-like receptors' two-edged sword: when immunity meets apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Apoptosis signaling in lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The biochemistry of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

CD95's deadly mission in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

21 January 2018

The BCL-2 family reunion

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Expansion and evolution of cell death programmes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Regulation of NF-kappaB responses by epigenetic suppression of IkappaBalpha expression in HCT116 intestinal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Expression of TLR-2, TLR-4, NOD2 and pNF-kappaB in a neonatal rat model of necrotizing enterocolitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

New insights into NF-kappaB regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Molecular Pathways Linking Inflammation and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Shared principles in NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

HMGB1 and RAGE in inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

CD14 but not MD2 transmit signals from DAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Partial role of TLR4 as a receptor responding to damage-associated molecular pattern.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

An ancient system of host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Self-defense: The fruit fly style

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Infection and apoptosis as a combined inflammatory trigger

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Immune effects and mechanisms of action of CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Contrasting activity of cytosin–guanosin dinucleotide oligonucleotides in mice with experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Function of Nod-like receptors in microbial recognition and host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Intracellular NOD-like receptors in host defense and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Secretory Mediators Regulate Nod2-Induced Tolerance in Human Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

NOD2 mutations and anti-Saccharomyces cerevisiae antibodies are risk factors for Crohn's disease in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Necrotizing enterocolitis: recent scientific advances in pathophysiology and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Neurodevelopmental outcomes of very low-birth-weight infants with necrotizing enterocolitis: a systematic review of observational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The immunological and genetic basis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Linkage of inflammatory bowel disease to human chromosome 6p

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Resistance to EGF-R (erbB-1) and VEGF-R modulating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

5-aminosalicylic acid is an attractive candidate agent for chemoprevention of colon cancer in patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Salmonella-mediated gene therapy in experimental colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Bacterial Colonization Affects the Intestinal Proteome of Preterm Pigs Susceptible to Necrotizing Enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Epithelial NEMO links innate immunity to chronic intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0821-4

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

21 January 2018

1 reference

12 December 2020

Aberrant expression of OX1 receptors for orexins in colon cancers and liver metastases: an openable gate to apoptosis

1 reference

12 December 2020

Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis

1 reference

12 December 2020

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.

1 reference

12 December 2020

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

1 reference

12 December 2020

Increased apoptosis accompanies neoplastic development in the human colorectum.

1 reference

12 December 2020

Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors

1 reference

12 December 2020

Proteins and an Inflammatory Network Expressed in Colon Tumors

1 reference

12 December 2020

Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy.

1 reference

12 December 2020

Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis

1 reference

12 December 2020

Crohn's disease: NOD2, autophagy and ER stress converge

1 reference

12 December 2020

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

1 reference

12 December 2020

DAMPening inflammation by modulating TLR signalling

1 reference

12 December 2020

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

1 reference

12 December 2020

New therapies and preventive approaches for necrotizing enterocolitis: report of a research planning workshop

1 reference

12 December 2020

Interleukin-19 protects mice from innate-mediated colonic inflammation

1 reference

12 December 2020

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

1 reference

12 December 2020

Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis

1 reference

12 December 2020

Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity.

1 reference

12 December 2020

A component of polysaccharide peptidoglycan complex on Lactobacillus induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer

1 reference

12 December 2020

Corticotropin-Releasing Factor Regulates TLR4 Expression in the Colon and Protects Mice From Colitis

1 reference

12 December 2020

CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice

1 reference

12 December 2020

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma

1 reference

12 December 2020

Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury

1 reference

12 December 2020

Intestinal alpha-defensin expression in pediatric inflammatory bowel disease

1 reference

12 December 2020

Endotoxin and hypoxia-induced intestinal necrosis in rats: the role of platelet activating factor

1 reference

12 December 2020

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

1 reference

12 December 2020

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis

1 reference

12 December 2020

CARD15 Gene Variants and Risk of Reoperation in Crohn's Disease Patients

1 reference

12 December 2020

APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells

1 reference

12 December 2020

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1 reference

12 December 2020

10.1007/S00018-011-0821-4

Identifiers

DOI

1 reference

25 August 2017

1 reference