Why Do Homocysteine‐Lowering B Vitamin and Antioxidant E Vitamin Supplementations Appear To Be Ineffective in the Prevention of Cardiovascular Diseases? (Q37925013)

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scientific article published on April 1, 2011

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English	Why Do Homocysteine‐Lowering B Vitamin and Antioxidant E Vitamin Supplementations Appear To Be Ineffective in the Prevention of Cardiovascular Diseases?	scientific article published on April 1, 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

1 reference

Europe PubMed Central

Why do homocysteine-lowering B vitamin and antioxidant E vitamin supplementations appear to be ineffective in the prevention of cardiovascular diseases? (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Why Do Homocysteine‐Lowering B Vitamin and Antioxidant E Vitamin Supplementations Appear To Be Ineffective in the Prevention of Cardiovascular Diseases? (English)

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

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cardiovascular disease

1 reference

based on heuristic

inferred from title

author name string

Balazs Debreceni

1

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Laszlo Debreceni

2

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Europe PubMed Central

PubMed publication ID

25 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 April 2011

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Europe PubMed Central

PubMed publication ID

25 August 2017

full work available at URL

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-5922.2011.00266.x

Portable Document Format

online access status

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21884001

11 December 2024

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1755-5922.2011.00266.x

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1755-5922.2011.00266.x

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

Cardiovascular Therapeutics

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

30

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Europe PubMed Central

PubMed publication ID

25 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

227-233

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Europe PubMed Central

PubMed publication ID

25 August 2017

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

The oxidant stress of hyperhomocyst(e)inemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Folic acid--an innocuous means to reduce plasma homocysteine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Efficacy of folic acid supplementation in stroke prevention: a meta-analysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Oral folate enhances endothelial function in hyperhomocysteinaemic subjects

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Pyridoxine prevents dysfunction of endothelial cell nitric oxide production in response to low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces postreperfusion injury

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

A cost-effectiveness analysis of folic acid fortification policy in the United States

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Improvement in stroke mortality in Canada and the United States, 1990 to 2002.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Vitamin E consumption and the risk of coronary disease in women

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine lowering with folic acid and B vitamins in vascular disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease--results of the renal Hope-2 study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine lowering and cardiovascular events after acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Relative effects of statin therapy on stroke and cardiovascular events in men and women: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Atorvastatin: its clinical role in cerebrovascular prevention

1 reference

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21 January 2018

Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Different time course for prevention of coronary and stroke events by atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Early decrease of oxidative stress by atorvastatin in hypercholesterolaemic patients: effect on circulating vitamin E.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Vitamin E and K interactions--a 50-year-old problem

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Haemorrhagic stroke during anti-platelet therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Vitamin Intervention For Stroke Prevention trial: an efficacy analysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Homocysteine-lowering B vitamin therapy in cardiovascular prevention--wrong again?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Folate and Vitamin B 6 From Diet and Supplements in Relation to Risk of Coronary Heart Disease Among Women

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Global Improvement of Vascular Function and Redox State With Low-Dose Folic Acid

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

What level of plasma homocyst(e)ine should be treated? Effects of vitamin therapy on progression of carotid atherosclerosis in patients with homocyst(e)ine levels above and below 14 μmol/L

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5922.2011.00266.X

21 January 2018

Mild hyperhomocysteinemia induced by feeding rats diets rich in methionine or deficient in folate promotes early atherosclerotic inflammatory processes

8

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

Homocysteine stimulates nuclear factor kappaB activity and interleukin-6 expression in rat vascular smooth muscle cells

9

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

Effects of homocysteine on endothelial nitric oxide production

13

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification

18

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling

28

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

High- but not low-dose folic acid improves endothelial function in coronary artery disease

29

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

Effect of folic acid treatment on carotid intima-media thickness of patients with coronary disease

33

1 reference

10.1111/J.1755-5922.2011.00266.X

https://api.crossref.org/works/10.1111/J.1755-5922.2011.00266.X

11 December 2024

Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia

36

1 reference

10.1111/J.1755-5922.2011.00266.X

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11 December 2024

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

45

1 reference

10.1111/J.1755-5922.2011.00266.X

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11 December 2024

Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial

46

1 reference

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11 December 2024

Vitamin E supplementation and cardiovascular events in high-risk patients

57

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Statin treatment as a confounding factor in human trials with vitamin E.

66

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alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism

68

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Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status

70

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Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

72

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11 December 2024

Identifiers

10.1111/J.1755-5922.2011.00266.X

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

ResearchGate publication ID

0 references

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