Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer. (Q37877173)

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1 February 2020

title

Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer (English)

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1 February 2020

main subject

metastatic breast cancer

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1 February 2020

Anastasia G Eleftheraki

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1 February 2020

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1 February 2020

E Razis

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1 February 2020

V Kotoula

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1 February 2020

K Pavlakis

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1 February 2020

P Papakostas

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1 February 2020

G Aravantinos

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1 February 2020

G Rigakos

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1 February 2020

I Efstratiou

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1 February 2020

K Petraki

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1 February 2020

D Bafaloukos

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1 February 2020

I Kostopoulos

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1 February 2020

D Pectasides

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1 February 2020

K T Kalogeras

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1 February 2020

D Skarlos

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1 February 2020

G Fountzilas

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1 February 2020

language of work or name

English

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publication date

19 May 2011

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Breast Cancer Research and Treatment

1 February 2020

published in

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1 February 2020

volume

128

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issue

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page(s)

447-456

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 February 2020

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies

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EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab.

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

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PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer

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